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ENZYME entry: EC 184.108.40.206
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|Dimethylaniline monooxygenase (N-oxide-forming).|
|Flavin mixed function oxidase.|
|Mixed-function amine oxidase.|
|N,N-dimethylaniline + NADPH + O(2) <=> N,N-dimethylaniline N-oxide + NADP(+) + H(2)O|
- A broad spectrum monooxygenase that accepts substrates as diverse as
hydrazines, phosphines, boron-containing compounds, sulfides,
selenides, iodide, as well as primary, secondary and tertiary amines.
- Is distinct from other monooxygenases in that the enzyme forms a
relatively stable hydroperoxy flavin intermediate.
- Generally converts nucleophilic heteroatom-containing chemicals and
drugs into harmless, readily excreted metabolites.
- For example, N-oxygenation is largely responsible for the
detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-
- Formerly EC 220.127.116.11.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|Q95LA2, FMO1_CANLF; ||P49328, FMO1_CAVPO; ||Q01740, FMO1_HUMAN; |
|P50285, FMO1_MOUSE; ||P16549, FMO1_PIG; ||P17636, FMO1_RABIT; |
|P36365, FMO1_RAT; ||P36366, FMO2_CAVPO; ||Q8HZ69, FMO2_GORGO; |
|Q99518, FMO2_HUMAN; ||Q28505, FMO2_MACMU; ||Q8K2I3, FMO2_MOUSE; |
|Q8HZ70, FMO2_PANTR; ||Q5REK0, FMO2_PONAB; ||P17635, FMO2_RABIT; |
|Q6IRI9, FMO2_RAT; ||Q8HYJ9, FMO3_BOVIN; ||Q95LA1, FMO3_CANLF; |
|P31513, FMO3_HUMAN; ||Q8SPQ7, FMO3_MACMU; ||P97501, FMO3_MOUSE; |
|Q7YS44, FMO3_PANTR; ||P32417, FMO3_RABIT; ||Q9EQ76, FMO3_RAT; |
|P31512, FMO4_HUMAN; ||Q8VHG0, FMO4_MOUSE; ||P36367, FMO4_RABIT; |
|Q8K4B7, FMO4_RAT; ||P49109, FMO5_CAVPO; ||P49326, FMO5_HUMAN; |
|P97872, FMO5_MOUSE; ||Q04799, FMO5_RABIT; ||Q8K4C0, FMO5_RAT; |
|O60774, FMO6_HUMAN; |
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