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ENZYME entry: EC 1.14.13.83

Accepted Name
Precorrin-3B synthase.
Alternative Name(s)
Precorrin-3X synthase.
Reaction catalysed
Precorrin-3A + NADH + O(2) <=> precorrin-3B + NAD(+) + H(2)O
Cofactor(s)
Iron-sulfur.
Comment(s)
  • An oxygen atom from dioxygen is incorporated into the macrocycle at C-20.
  • In the aerobic cobalamin biosynthesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • This enzyme carries out the first of the four steps, yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
Cross-references
BRENDA1.14.13.83
EC2PDB1.14.13.83
ExplorEnz1.14.13.83
PRIAM enzyme-specific profiles1.14.13.83
KEGG Ligand Database for Enzyme Nomenclature1.14.13.83
IUBMB Enzyme Nomenclature1.14.13.83
IntEnz1.14.13.83
MEDLINEFind literature relating to 1.14.13.83
MetaCyc1.14.13.83
UniProtKB/Swiss-Prot
P21637, COBG_PSEDE

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