ENZYME entry: EC 1.14.13.83
| Accepted Name |
|---|
| Precorrin-3B synthase.
|
| Alternative Name(s) |
|---|
| Precorrin-3X synthase. |
| Reaction catalysed |
|---|
| Precorrin-3A + NADH + O(2) <=> precorrin-3B + NAD(+) + H(2)O |
| Cofactor(s) |
|---|
| Iron-sulfur.
|
| Comment(s) |
|---|
- An oxygen atom from dioxygen is incorporated into the macrocycle at
C-20.
- In the aerobic cobalamin biosynthesis pathway, four enzymes are
involved in the conversion of precorrin-3A to precorrin-6A.
- This enzyme carries out the first of the four steps, yielding
precorrin-3B as the product.
- This is followed by three methylation reactions, which introduce a
methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and
C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-
4, precorrin-5 and precorrin-6A, respectively.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.83 |
| EC2PDB | 1.14.13.83 |
| ExplorEnz | 1.14.13.83 |
| PRIAM enzyme-specific profiles | 1.14.13.83 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.83 |
| IUBMB Enzyme Nomenclature | 1.14.13.83 |
| IntEnz | 1.14.13.83 |
| MEDLINE | Find literature relating to 1.14.13.83 |
| MetaCyc | 1.14.13.83 |
| UniProtKB/Swiss-Prot |
|
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