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ENZYME entry: EC 1.14.14.1

Accepted Name
Unspecific monooxygenase.
Alternative Name(s)
Aryl hydrocarbon hydroxylase.
Aryl-4-monooxygenase.
Cytochrome P450.
Flavoprotein-linked monooxygenase.
Microsomal monooxygenase.
Microsomal P450.
Xenobiotic monooxygenase.
Reaction catalysed
RH + [reduced NADPH--hemoprotein reductase] + O(2) <=> ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.1
EC2PDB1.14.14.1
ExplorEnz1.14.14.1
PRIAM enzyme-specific profiles1.14.14.1
KEGG Ligand Database for Enzyme Nomenclature1.14.14.1
IUBMB Enzyme Nomenclature1.14.14.1
IntEnz1.14.14.1
MEDLINEFind literature relating to 1.14.14.1
MetaCyc1.14.14.1
UniProtKB/Swiss-Prot
Q81BF4, C102_BACCR;  Q9PVE8, C330_FUNHE;  Q98T91, C340_ORYLA;  
Q8AXY5, C356_FUNHE;  Q2UNA2, C505_ASPOR;  Q9Y8G7, C505_FUSOX;  
O23066, C86A2_ARATH;  Q9LMM1, C86A4_ARATH;  Q9CAD6, C86A7_ARATH;  
O80823, C86A8_ARATH;  Q3LFU0, CP1A1_BALAC;  P56590, CP1A1_CANLF;  
Q06367, CP1A1_CAVPO;  Q92039, CP1A1_CHACA;  P79716, CP1A1_DICLA;  
Q5KQT7, CP1A1_FELCA;  P04798, CP1A1_HUMAN;  O42430, CP1A1_LIMLI;  
O42231, CP1A1_LIZAU;  Q9W683, CP1A1_LIZSA;  P33616, CP1A1_MACFA;  
Q6GUR1, CP1A1_MACMU;  Q00557, CP1A1_MESAU;  Q92148, CP1A1_MICTO;  
P00184, CP1A1_MOUSE;  Q92110, CP1A1_ONCMY;  Q92095, CP1A1_OPSTA;  
Q6JZS3, CP1A1_ORYLA;  P98181, CP1A1_PAGMA;  Q9YH64, CP1A1_PLAFE;  
Q92100, CP1A1_PLEPL;  P05176, CP1A1_RABIT;  P00185, CP1A1_RAT;  
P56591, CP1A1_SHEEP;  O42457, CP1A1_SPAAU;  Q92116, CP1A1_STECH;  
Q3LFT9, CP1A2_BALAC;  O77810, CP1A2_CALJA;  P56592, CP1A2_CANLF;  
Q64391, CP1A2_CAVPO;  Q01741, CP1A2_CHICK;  Q5KQT6, CP1A2_FELCA;  
P05177, CP1A2_HUMAN;  O77809, CP1A2_MACFA;  Q4H4C3, CP1A2_MACFU;  
P24453, CP1A2_MESAU;  P00186, CP1A2_MOUSE;  Q5RBQ1, CP1A2_PONAB;  
P00187, CP1A2_RABIT;  P04799, CP1A2_RAT;  Q92109, CP1A3_ONCMY;  
P79760, CP1A4_CHICK;  P79761, CP1A5_CHICK;  Q16678, CP1B1_HUMAN;  
Q64429, CP1B1_MOUSE;  Q64678, CP1B1_RAT;  P56654, CP237_MOUSE;  
P56655, CP238_MOUSE;  P56656, CP239_MOUSE;  P56657, CP240_MOUSE;  
O62671, CP241_CANLF;  P79402, CP242_PIG;  Q6XVG2, CP254_MOUSE;  
Q9D816, CP255_MOUSE;  P33273, CP255_RAT;  Q91W64, CP270_MOUSE;  
P19225, CP270_RAT;  P11711, CP2A1_RAT;  P15149, CP2A2_RAT;  
P20812, CP2A3_RAT;  P15392, CP2A4_MOUSE;  P20852, CP2A5_MOUSE;  
P20853, CP2A7_HUMAN;  P80055, CP2A7_PAPSP;  P24454, CP2A8_MESAU;  
P24455, CP2A9_MESAU;  Q05555, CP2AA_RABIT;  Q05556, CP2AB_RABIT;  
P56593, CP2AC_MOUSE;  Q16696, CP2AD_HUMAN;  P22779, CP2AX_BOVIN;  
P00176, CP2B1_RAT;  P04167, CP2B2_RAT;  P13107, CP2B3_RAT;  
P00178, CP2B4_RABIT;  P12789, CP2B5_RABIT;  P12790, CP2B9_MOUSE;  
P12791, CP2BA_MOUSE;  P24460, CP2BB_CANLF;  P33272, CP2BC_RAT;  
Q64583, CP2BF_RAT;  O55071, CP2BJ_MOUSE;  P34033, CP2BX_CAVPO;  
P00180, CP2C1_RABIT;  P00181, CP2C2_RABIT;  P00182, CP2C3_RABIT;  
P11371, CP2C4_RABIT;  P00179, CP2C5_RABIT;  P05178, CP2C6_RAT;  
P05179, CP2C7_RAT;  P10632, CP2C8_HUMAN;  P08683, CP2CB_RAT;  
P11510, CP2CC_RAT;  P20814, CP2CD_RAT;  P17666, CP2CE_RABIT;  
P11372, CP2CF_RABIT;  P15123, CP2CG_RABIT;  P33260, CP2CI_HUMAN;  
P33262, CP2CK_MACFA;  P56594, CP2CL_CANLF;  P24470, CP2CN_RAT;  
Q08078, CP2CP_MESAU;  P33263, CP2CQ_MESAU;  P33264, CP2CR_MESAU;  
P33265, CP2CS_MESAU;  Q64458, CP2CT_MOUSE;  Q29510, CP2CU_RABIT;  
Q29478, CP2CV_CAPHE;  P10633, CP2D1_RAT;  P12938, CP2D3_RAT;  
Q64680, CP2D4_RAT;  P10635, CP2D6_HUMAN;  Q2XNC9, CP2D6_PANPA;  
Q2XNC8, CP2D6_PANTR;  A0A087X1C5, CP2D7_HUMAN;  P11714, CP2D9_MOUSE;  
P24456, CP2DA_MOUSE;  P12939, CP2DA_RAT;  P24457, CP2DB_MOUSE;  
Q01361, CP2DE_BOVIN;  Q29473, CP2DF_CANLF;  Q64403, CP2DG_CAVPO;  
Q29488, CP2DH_MACFA;  O18992, CP2DJ_CALJA;  Q8CIM7, CP2DQ_MOUSE;  
P10634, CP2DQ_RAT;  P24903, CP2F1_HUMAN;  O18809, CP2F3_CAPHI;  
Q8WNE1, CP2F5_GORGO;  P24461, CP2G1_RABIT;  P10610, CP2G1_RAT;  
P05180, CP2H1_CHICK;  P20678, CP2H2_CHICK;  P52786, CP2J1_RABIT;  
P51589, CP2J2_HUMAN;  P51590, CP2J3_RAT;  O54749, CP2J5_MOUSE;  
O54750, CP2J6_MOUSE;  Q92090, CP2K1_ONCMY;  O93299, CP2K3_ONCMY;  
O93297, CP2K4_ONCMY;  Q27712, CP2L1_PANAR;  Q92088, CP2M1_ONCMY;  
Q96SQ9, CP2S1_HUMAN;  Q9DBX6, CP2S1_MOUSE;  Q0IIF9, CP2U1_BOVIN;  
Q7Z449, CP2U1_HUMAN;  Q9CX98, CP2U1_MOUSE;  Q4V8D1, CP2U1_RAT;  
Q9JMA7, CP341_MOUSE;  Q9HB55, CP343_HUMAN;  P04800, CP3A1_RAT;  
P05183, CP3A2_RAT;  P08684, CP3A4_HUMAN;  P20815, CP3A5_HUMAN;  
P80056, CP3A5_PAPSP;  P11707, CP3A6_RABIT;  P24462, CP3A7_HUMAN;  
P33268, CP3A8_MACFA;  P51538, CP3A9_RAT;  Q64459, CP3AB_MOUSE;  
P24463, CP3AC_CANLF;  Q64464, CP3AD_MOUSE;  Q64417, CP3AE_CAVPO;  
Q64406, CP3AF_CAVPO;  Q64481, CP3AG_MOUSE;  Q64409, CP3AH_CAVPO;  
Q64581, CP3AI_RAT;  P79152, CP3AJ_CAPHE;  O18993, CP3AL_CALJA;  
Q29496, CP3AO_SHEEP;  O09158, CP3AP_MOUSE;  O42563, CP3AR_ONCMY;  
P79102, CP3AS_BOVIN;  P79401, CP3AT_PIG;  O70537, CP3AV_MESAU;  
P10611, CP4A4_RABIT;  P24464, CP4AC_RAT;  P13584, CP4B1_HUMAN;  
Q64462, CP4B1_MOUSE;  P15128, CP4B1_RABIT;  P15129, CP4B1_RAT;  
P29981, CP4C1_BLADI;  Q91WL5, CP4CA_MOUSE;  Q964T1, CP4CU_BLAGE;  
P33274, CP4F1_RAT;  P51869, CP4F4_RAT;  P51870, CP4F5_RAT;  
P51871, CP4F6_RAT;  P98187, CP4F8_HUMAN;  Q9HCS2, CP4FC_HUMAN;  
Q8N118, CP4X1_HUMAN;  Q6A152, CP4X1_MOUSE;  Q8K4D6, CP4X1_RAT;  
Q86W10, CP4Z1_HUMAN;  P13527, CP6A1_MUSDO;  Q04552, CP6B1_PAPPO;  
Q27664, CP6B2_HELAM;  Q27756, CP6B3_PAPPO;  Q27902, CP6B4_PAPGL;  
Q95036, CP6B5_PAPGL;  Q95031, CP6B6_HELAM;  O61387, CP6B7_HELAM;  
P14779, CPXB_BACMB;  Q91X77, CY250_MOUSE;  O08336, CYPB_BACSU;  
O08394, CYPD_BACSU;  Q9HGE0, FUM6_GIBM7;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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