ENZYME entry: EC 1.6.2.4

Accepted Name
NADPH--hemoprotein reductase.
Alternative Name(s)
Aldehyde reductase (NADPH-dependent).
CPR.
Cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent).
Cytochrome P450 reductase.
Dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
FAD-cytochrome c reductase.
Ferrihemoprotein P-450 reductase.
NADP--cytochrome c reductase.
NADP--cytochrome reductase.
NADPH--cytochrome c oxidoreductase.
NADPH--cytochrome c reductase.
NADPH--cytochrome P450 oxidoreductase.
NADPH--cytochrome P450 reductase.
NADPH--ferricytochrome c oxidoreductase.
NADPH--ferrihemoprotein reductase.
NADPH-dependent cytochrome c reductase.
NADPH:ferrihemoprotein oxidoreductase.
NADPH:P450 reductase.
Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate).
TPNH(2) cytochrome c reductase.
TPNH-cytochrome c reductase.
Reaction catalysed
NADPH + n oxidized hemoprotein <=> NADP(+) + n reduced hemoprotein
Cofactor(s)
FAD; FMN.
Comment(s)
  • This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
  • It also reduces cytochrome b5 and cytochrome c.
  • The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
Cross-references
BRENDA1.6.2.4
EC2PDB1.6.2.4
ExplorEnz1.6.2.4
PRIAM enzyme-specific profiles1.6.2.4
KEGG Ligand Database for Enzyme Nomenclature1.6.2.4
IUBMB Enzyme Nomenclature1.6.2.4
IntEnz1.6.2.4
MEDLINEFind literature relating to 1.6.2.4
MetaCyc1.6.2.4
UniProtKB/Swiss-Prot
Q81BF4, C102_BACCR;  Q2UNA2, C505_ASPOR;  Q9Y8G7, C505_FUSOX;  
P14779, CPXB_BACMB;  O08336, CYPB_BACSU;  O08394, CYPD_BACSU;  
Q9SB48, NCPR1_ARATH;  Q9SUM3, NCPR2_ARATH;  Q4WM67, NCPR_ASPFU;  
A2QS05, NCPR_ASPNC;  Q00141, NCPR_ASPNG;  Q2UHA7, NCPR_ASPOR;  
Q0CMM0, NCPR_ASPTN;  Q3SYT8, NCPR_BOVIN;  P50126, NCPR_CANMA;  
P37201, NCPR_CANTR;  Q05001, NCPR_CATRO;  P37039, NCPR_CAVPO;  
Q55CT1, NCPR_DICDI;  Q27597, NCPR_DROME;  Q5BFT5, NCPR_EMENI;  
P16435, NCPR_HUMAN;  P37040, NCPR_MOUSE;  Q07994, NCPR_MUSDO;  
Q9HDG2, NCPR_PHACH;  P04175, NCPR_PIG;  P00389, NCPR_RABIT;  
P00388, NCPR_RAT;  P19618, NCPR_SALTR;  P36587, NCPR_SCHPO;  
P37116, NCPR_VIGRR;  P16603, NCPR_YEAST;  

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