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ENZYME entry: EC 1.14.14.24

Accepted Name
Vitamin D 25-hydroxylase.
Alternative Name(s)
CYP2R1.
Vitamin D(2) 25-hydroxylase.
Vitamin D(3) 25-hydroxylase.
Reaction catalysed
Calciol + O(2) + [reduced NADPH--hemoprotein reductase] <=> calcidiol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D(3).
  • While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is thought to catalyze the reaction in humans in vivo.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.159.
Cross-references
BRENDA1.14.14.24
EC2PDB1.14.14.24
ExplorEnz1.14.14.24
PRIAM enzyme-specific profiles1.14.14.24
KEGG Ligand Database for Enzyme Nomenclature1.14.14.24
IUBMB Enzyme Nomenclature1.14.14.24
IntEnz1.14.14.24
MEDLINEFind literature relating to 1.14.14.24
MetaCyc1.14.14.24
UniProtKB/Swiss-Prot
Q6VVX0, CP2R1_HUMAN;  Q6VVW9, CP2R1_MOUSE;  

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