ENZYME entry: EC 1.14.17.3

Accepted Name
Peptidylglycine monooxygenase.
Alternative Name(s)
PAM.
Peptidyl alpha-amidating enzyme.
Peptidylglycine 2-hydroxylase.
Peptidylglycine alpha-amidating monooxygenase.
Reaction catalysed
Peptidylglycine + ascorbate + O(2) <=> peptidyl(2-hydroxyglycine) + dehydroascorbate + H(2)O
Cofactor(s)
Copper.
Comment(s)
  • Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme.
  • The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalyzed by EC 4.3.2.5.
  • Involved in the final step of biosynthesis of alpha-melanotropin and related biologically active peptides.
Cross-references
PROSITEPDOC00080
BRENDA1.14.17.3
EC2PDB1.14.17.3
ExplorEnz1.14.17.3
PRIAM enzyme-specific profiles1.14.17.3
KEGG Ligand Database for Enzyme Nomenclature1.14.17.3
IUBMB Enzyme Nomenclature1.14.17.3
IntEnz1.14.17.3
MEDLINEFind literature relating to 1.14.17.3
MetaCyc1.14.17.3
UniProtKB/Swiss-Prot
P08478, AMDA_XENLA;  P12890, AMDB_XENLA;  P83388, AMDL_CAEEL;  
P10731, AMD_BOVIN;  P19021, AMD_HUMAN;  P97467, AMD_MOUSE;  
P14925, AMD_RAT;  Q95XM2, PHM_CAEEL;  O01404, PHM_DROME;  

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