ENZYME entry: EC 1.14.19.4

Accepted Name
Delta(8)-fatty-acid desaturase.
Alternative Name(s)
Delta(8)-desaturase.
Delta(8)-sphingolipid desaturase.
EFD1.
SLD.
Reaction catalysed
Phytosphinganine + reduced acceptor + O(2) <=> Delta(8)-phytosphingenine + acceptor + 2 H(2)O
Comment(s)
  • This enzyme, which has been found mainly in plants, introduces a double bond at Delta(8) of C(18) and C(20) fatty acids.
  • The enzyme from the marine microalga Euglena gracilis requires a double bond to be present at Delta(11) and is most active with 20:3 Delta(11,14,17) and 20:2 Delta(11,14) as substrates, although it can also desaturate 20:1 Delta(11).
  • The Delta(8)-desaturation pathway represents an alternate pathway for the synthesis of the polyunsaturated fatty acids arachidonate (C20:4 Delta(5,14)) and eicosapentaenoate (C20:5 Delta(5,17)) in organisms lacking a Delta(6)-desaturase.
  • Formerly EC 1.14.19.n1.
Cross-references
PROSITEPDOC00170
BRENDA1.14.19.4
EC2PDB1.14.19.4
ExplorEnz1.14.19.4
PRIAM enzyme-specific profiles1.14.19.4
KEGG Ligand Database for Enzyme Nomenclature1.14.19.4
IUBMB Enzyme Nomenclature1.14.19.4
IntEnz1.14.19.4
MEDLINEFind literature relating to 1.14.19.4
MetaCyc1.14.19.4

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