ENZYME entry: EC 1.14.19.5
| Accepted Name |
|---|
| Delta(11)-fatty-acid desaturase.
|
| Alternative Name(s) |
|---|
| Delta(11) desaturase. |
| Delta(11)-palmitoyl-CoA desaturase. |
| Fatty acid Delta(11)-desaturase. |
| Z/E11-desaturase. |
| Reaction catalysed |
|---|
| Acyl-CoA + reduced acceptor + O(2) <=> Delta(11)-acyl-CoA + acceptor + 2 H(2)O |
| Comment(s) |
|---|
- In common with front-end desaturases involved in the synthesis of
polyunsaturated fatty acids (PUFAs), this membrane-bound enzyme has a
cytochrome b5-like domain at the N-terminus and contains three
histidine boxes that are critical for desaturase activity.
- The enzyme from the marine microalga Thalassiosira pseudonana
specifically desaturates palmitic acid 16:0 to 16:1-Delta(11) whereas
that from the leafroller moth Choristoneura rosaceana desaturates
myristic acid 14:0 to 14:1-Delta(11).
- 16:1-Delta(11) represents an important precursor for pheromone
synthesis in insect cells, although its function in microalgae is
currently unknown.
- The enzyme from the Egyptian cotton leafworm Spodoptera littoralis
has a preference for palmitoyl-CoA as substrate and for NADH rather
than NADPH as reduced acceptor.
- Formerly EC 1.14.19.n2.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.5 |
| EC2PDB | 1.14.19.5 |
| ExplorEnz | 1.14.19.5 |
| PRIAM enzyme-specific profiles | 1.14.19.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.5 |
| IUBMB Enzyme Nomenclature | 1.14.19.5 |
| IntEnz | 1.14.19.5 |
| MEDLINE | Find literature relating to 1.14.19.5 |
| MetaCyc | 1.14.19.5 |
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