ENZYME entry: EC 1.14.19.7
| Accepted Name |
|---|
| (S)-2-hydroxypropylphosphonic acid epoxidase.
|
| Alternative Name(s) |
|---|
| (S)-2-hydroxypropylphosphonate epoxidase. |
| 2-hydroxypropylphosphonic acid epoxidase. |
| HPP epoxidase. |
| Reaction catalysed |
|---|
| (S)-2-hydroxypropylphosphonate + NADH + O(2) <=> (1R,2S)-epoxypropylphosphonate + 2 H(2)O + NAD(+) |
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- FMN is required to mediate the transfer of reducing equivalents from
NADH to the active site iron.
- This is the last enzyme in the biosynthetic pathway of fosfomycin,
a broad-spectrum antibiotic produced by certain Streptomyces species.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.7 |
| EC2PDB | 1.14.19.7 |
| ExplorEnz | 1.14.19.7 |
| PRIAM enzyme-specific profiles | 1.14.19.7 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.7 |
| IUBMB Enzyme Nomenclature | 1.14.19.7 |
| IntEnz | 1.14.19.7 |
| MEDLINE | Find literature relating to 1.14.19.7 |
| MetaCyc | 1.14.19.7 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-