ENZYME entry: EC 1.17.7.1

Accepted Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin).
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase.
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.
Reaction catalysed
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin <=> 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis.
  • Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3).
  • The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin.
  • Formerly EC 1.17.4.3.
Cross-references
BRENDA1.17.7.1
EC2PDB1.17.7.1
ExplorEnz1.17.7.1
PRIAM enzyme-specific profiles1.17.7.1
KEGG Ligand Database for Enzyme Nomenclature1.17.7.1
IUBMB Enzyme Nomenclature1.17.7.1
IntEnz1.17.7.1
MEDLINEFind literature relating to 1.17.7.1
MetaCyc1.17.7.1
UniProtKB/Swiss-Prot
B0C6E1, ISPG_ACAM1;  Q3MG27, ISPG_ANAVT;  F4K0E8, ISPG_ARATH;  
B1WQF1, ISPG_CYAA5;  B8HSI6, ISPG_CYAP4;  B7KJJ4, ISPG_CYAP7;  
B7K5R5, ISPG_CYAP8;  Q7NFA4, ISPG_GLOVI;  B0JJJ8, ISPG_MICAN;  
B2J1G1, ISPG_NOSP7;  P58666, ISPG_NOSS1;  Q6K8J4, ISPG_ORYSJ;  
Q7VBS7, ISPG_PROMA;  Q7V7G9, ISPG_PROMM;  Q7V215, ISPG_PROMP;  
Q31QC4, ISPG_SYNE7;  Q2JS69, ISPG_SYNJA;  Q2JPZ9, ISPG_SYNJB;  
B1XHZ7, ISPG_SYNP2;  Q5N3W3, ISPG_SYNP6;  Q7U712, ISPG_SYNPX;  
Q0I9J4, ISPG_SYNS3;  Q3AXP3, ISPG_SYNS9;  Q3AK30, ISPG_SYNSC;  
P73672, ISPG_SYNY3;  Q8DK70, ISPG_THEEB;  Q10W70, ISPG_TRIEI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
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