ENZYME entry: EC 1.17.7.1

Accepted Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase.
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.
Reaction catalysed
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin <=> 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Forms, in the reverse direction, part of an alternative non- mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria and in plant chloroplasts.
  • The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with the flavodoxin/flavodoxin reductase/NADPH system that can be used as an electron donor by Escherichia coli.
  • Metabolites derived from isoprenoids play important roles in systems such as electron transport, photosynthesis, plant defense responses, hormonal regulation of development and membrane fluidity.
  • Formerly EC 1.17.4.3.
Cross-references
BRENDA1.17.7.1
EC2PDB1.17.7.1
ExplorEnz1.17.7.1
PRIAM enzyme-specific profiles1.17.7.1
KEGG Ligand Database for Enzyme Nomenclature1.17.7.1
IUBMB Enzyme Nomenclature1.17.7.1
IntEnz1.17.7.1
MEDLINEFind literature relating to 1.17.7.1
MetaCyc1.17.7.1
UniProtKB/Swiss-Prot
Q82K43, ISPG1_STRAW;  Q9X7W2, ISPG1_STRCO;  Q82ML3, ISPG2_STRAW;  
Q9KYR9, ISPG2_STRCO;  B0C6E1, ISPG_ACAM1;  Q6FEM3, ISPG_ACIAD;  
B7H069, ISPG_ACIB3;  B7I5G7, ISPG_ACIB5;  B2I3E5, ISPG_ACIBC;  
B0VKR8, ISPG_ACIBS;  A3M211, ISPG_ACIBT;  B0V5G7, ISPG_ACIBY;  
A0LV34, ISPG_ACIC1;  A5FX97, ISPG_ACICJ;  B7JC30, ISPG_ACIF2;  
B5EJF3, ISPG_ACIF5;  A3N1H8, ISPG_ACTP2;  B3GY64, ISPG_ACTP7;  
B0BQB9, ISPG_ACTPJ;  A6VQX6, ISPG_ACTSZ;  B9JE02, ISPG_AGRRK;  
P58665, ISPG_AGRT5;  B9JV07, ISPG_AGRVS;  B2UKT9, ISPG_AKKM8;  
Q0VNE0, ISPG_ALCBS;  B6EGY7, ISPG_ALISL;  B4RV89, ISPG_ALTMD;  
Q5PAJ1, ISPG_ANAMM;  Q3MG27, ISPG_ANAVT;  B7GH89, ISPG_ANOFW;  
O67496, ISPG_AQUAE;  F4K0E8, ISPG_ARATH;  Q5P7B3, ISPG_AROAE;  
A1R501, ISPG_ARTAT;  B8HG44, ISPG_ARTCA;  A0JUS8, ISPG_ARTS2;  
C1DE57, ISPG_AZOVD;  A7Z6S2, ISPG_BACA2;  C3P8I5, ISPG_BACAA;  
C3LKV7, ISPG_BACAC;  A0RIQ2, ISPG_BACAH;  Q81LV7, ISPG_BACAN;  
B7JN03, ISPG_BACC0;  Q730Q8, ISPG_BACC1;  B7IYD0, ISPG_BACC2;  
C1ES01, ISPG_BACC3;  B7HCQ3, ISPG_BACC4;  B7HPH8, ISPG_BACC7;  
A7GSX5, ISPG_BACCN;  B9IY45, ISPG_BACCQ;  Q818H8, ISPG_BACCR;  
Q634Q9, ISPG_BACCZ;  Q5L7W2, ISPG_BACFN;  Q64N34, ISPG_BACFR;  
Q9KD18, ISPG_BACHD;  Q6HDN9, ISPG_BACHK;  Q65HA9, ISPG_BACLD;  
A8FF87, ISPG_BACP2;  Q5WHB2, ISPG_BACSK;  P54482, ISPG_BACSU;  
Q8A4T0, ISPG_BACTN;  A6L089, ISPG_BACV8;  A9VH61, ISPG_BACWK;  
A1UR54, ISPG_BARBK;  Q6G1X4, ISPG_BARHE;  Q6G104, ISPG_BARQU;  
A9IYW1, ISPG_BART1;  Q1LU77, ISPG_BAUCH;  B2IE63, ISPG_BEII9;  
Q8G7Y6, ISPG_BIFLO;  Q492E0, ISPG_BLOPB;  Q7WHN0, ISPG_BORBR;  
Q7W6P6, ISPG_BORPA;  Q7VWL0, ISPG_BORPE;  Q89VV9, ISPG_BRADU;  
A5ETI5, ISPG_BRASB;  A4YKQ8, ISPG_BRASO;  C0ZF58, ISPG_BREBN;  
B2S7K6, ISPG_BRUA1;  Q2YLG4, ISPG_BRUA2;  Q57BA5, ISPG_BRUAB;  
A9M820, ISPG_BRUC2;  C0RF32, ISPG_BRUMB;  Q8YJ17, ISPG_BRUME;  
A9WWQ2, ISPG_BRUSI;  Q8FYT2, ISPG_BRUSU;  P57374, ISPG_BUCAI;  
Q8K9P4, ISPG_BUCAP;  B1YR44, ISPG_BURA4;  B4EAW9, ISPG_BURCJ;  
A3MK75, ISPG_BURM7;  A2S2A2, ISPG_BURM9;  Q62JW4, ISPG_BURMA;  
A1V4K1, ISPG_BURMS;  A3NVX1, ISPG_BURP0;  Q3JRQ3, ISPG_BURP1;  
A3NA54, ISPG_BURP6;  Q63UT3, ISPG_BURPS;  Q8RA30, ISPG_CALS4;  
A4XLZ4, ISPG_CALS8;  A7ZCT9, ISPG_CAMC1;  A7GZ54, ISPG_CAMC5;  
A0RPL8, ISPG_CAMFF;  A8FLB6, ISPG_CAMJ8;  A7H4D8, ISPG_CAMJD;  
Q9PPM1, ISPG_CAMJE;  A1VZ41, ISPG_CAMJJ;  Q5HV95, ISPG_CAMJR;  
B9KD64, ISPG_CAMLR;  Q9A9W0, ISPG_CAUCR;  B3PDM1, ISPG_CELJU;  
Q5L669, ISPG_CHLAB;  Q823I7, ISPG_CHLCV;  Q254D2, ISPG_CHLFF;  
Q9PKY3, ISPG_CHLMU;  Q9Z8H0, ISPG_CHLPN;  B0B9G5, ISPG_CHLT2;  
Q3KMW4, ISPG_CHLTA;  B0BB44, ISPG_CHLTB;  Q8KG23, ISPG_CHLTE;  
O84060, ISPG_CHLTR;  Q1QTK8, ISPG_CHRSD;  Q7NS88, ISPG_CHRVO;  
A8AD71, ISPG_CITK8;  A5CT01, ISPG_CLAM3;  B0RDZ5, ISPG_CLAMS;  
Q97I56, ISPG_CLOAB;  B8I6E1, ISPG_CLOCE;  P58667, ISPG_CLOPE;  
Q895K3, ISPG_CLOTE;  Q47WC0, ISPG_COLP3;  Q6NGL3, ISPG_CORDI;  
Q8FP82, ISPG_COREF;  Q8NP12, ISPG_CORGL;  Q4JV28, ISPG_CORJK;  
B1VGA4, ISPG_CORU7;  A7MGV7, ISPG_CROS8;  B1WQF1, ISPG_CYAA5;  
B8HSI6, ISPG_CYAP4;  B7KJJ4, ISPG_CYAP7;  B7K5R5, ISPG_CYAP8;  
Q47BR6, ISPG_DECAR;  A5FS85, ISPG_DEHMB;  Q3ZZC9, ISPG_DEHMC;  
Q9RXC9, ISPG_DEIRA;  C6BYK9, ISPG_DESAD;  Q6AP32, ISPG_DESPS;  
Q72CD9, ISPG_DESVH;  A8LI72, ISPG_DINSH;  A7ZPV8, ISPG_ECO24;  
B7UGW1, ISPG_ECO27;  B7MI00, ISPG_ECO45;  B7LDA7, ISPG_ECO55;  
P62622, ISPG_ECO57;  B5Z0Y4, ISPG_ECO5E;  B7NRG5, ISPG_ECO7I;  
B7MYF0, ISPG_ECO81;  B7M7L9, ISPG_ECO8A;  C4ZX90, ISPG_ECOBW;  
B1XAZ0, ISPG_ECODH;  A8A321, ISPG_ECOHS;  A1AE53, ISPG_ECOK1;  
Q0TEX0, ISPG_ECOL5;  P62621, ISPG_ECOL6;  B1IWE6, ISPG_ECOLC;  
P62620, ISPG_ECOLI;  B7N6A3, ISPG_ECOLU;  B6I587, ISPG_ECOSE;  
B1LNH0, ISPG_ECOSM;  Q1R8L8, ISPG_ECOUT;  Q3YRZ7, ISPG_EHRCJ;  
Q5FHA6, ISPG_EHRRG;  Q5HB57, ISPG_EHRRW;  A4WD93, ISPG_ENT38;  
B2VE89, ISPG_ERWT9;  B7LKC3, ISPG_ESCF3;  B1YLA2, ISPG_EXIS2;  
C4L3K5, ISPG_EXISA;  Q0RDR2, ISPG_FRAAA;  Q2J717, ISPG_FRASC;  
A8L6E2, ISPG_FRASN;  Q14IL6, ISPG_FRAT1;  B2SG03, ISPG_FRATM;  
A0Q6U8, ISPG_FRATN;  Q0BMA6, ISPG_FRATO;  Q5NH64, ISPG_FRATT;  
Q8RG40, ISPG_FUSNN;  Q5KX35, ISPG_GEOKA;  Q74D60, ISPG_GEOSL;  
C5D4Q3, ISPG_GEOSW;  A4IQZ4, ISPG_GEOTN;  Q7NFA4, ISPG_GLOVI;  
A9HJ48, ISPG_GLUDA;  Q5FUR7, ISPG_GLUOX;  Q0BUK0, ISPG_GRABC;  
Q7VME2, ISPG_HAEDU;  Q4QNH4, ISPG_HAEI8;  A5UAB9, ISPG_HAEIE;  
A5UGH1, ISPG_HAEIG;  P44667, ISPG_HAEIN;  Q2SDW4, ISPG_HAHCH;  
C4K4I8, ISPG_HAMD5;  Q17XU2, ISPG_HELAH;  Q7VI04, ISPG_HELHP;  
B6JLL3, ISPG_HELP2;  B5Z6Z7, ISPG_HELPG;  Q1CTP7, ISPG_HELPH;  
Q9ZLL0, ISPG_HELPJ;  B2UTK0, ISPG_HELPS;  O25342, ISPG_HELPY;  
Q0I2E9, ISPG_HISS1;  B0USG8, ISPG_HISS2;  B4U9V3, ISPG_HYDS0;  
Q0C4J3, ISPG_HYPNA;  Q5QYA9, ISPG_IDILO;  Q28R10, ISPG_JANSC;  
B5XNL5, ISPG_KLEP3;  A6TCD4, ISPG_KLEP7;  B2GKS3, ISPG_KOCRD;  
Q1IRS5, ISPG_KORVE;  C1DD43, ISPG_LARHH;  Q1MSE5, ISPG_LAWIP;  
Q6AEX9, ISPG_LEIXX;  Q04UL2, ISPG_LEPBJ;  Q04YW2, ISPG_LEPBL;  
Q72TR2, ISPG_LEPIC;  Q8F1H5, ISPG_LEPIN;  C1L2Z7, ISPG_LISMC;  
Q71ZM9, ISPG_LISMF;  P58668, ISPG_LISMO;  B1HSS4, ISPG_LYSSC;  
B9E6U1, ISPG_MACCJ;  A0LDN3, ISPG_MAGSM;  Q65R84, ISPG_MANSM;  
A1TZQ0, ISPG_MARHV;  A6VV06, ISPG_MARMS;  Q604Q5, ISPG_METCA;  
Q1H0U9, ISPG_METFK;  B0JJJ8, ISPG_MICAN;  Q7TXN6, ISPG_MYCBO;  
A1KML3, ISPG_MYCBP;  C1AFY4, ISPG_MYCBT;  Q7NBH3, ISPG_MYCGA;  
B8ZRU5, ISPG_MYCLB;  Q9CBU5, ISPG_MYCLE;  Q73VS3, ISPG_MYCPA;  
Q8EUI6, ISPG_MYCPE;  A5U6M2, ISPG_MYCTA;  P9WKG2, ISPG_MYCTO;  
P9WKG3, ISPG_MYCTU;  B2A390, ISPG_NATTJ;  B9LA27, ISPG_NAUPA;  
Q5F913, ISPG_NEIG1;  B4RMG4, ISPG_NEIG2;  A9LZN8, ISPG_NEIM0;  
Q9JU34, ISPG_NEIMA;  Q9JZ40, ISPG_NEIMB;  A1KUD8, ISPG_NEIMF;  
Q0AE42, ISPG_NITEC;  Q82XV0, ISPG_NITEU;  Q1QQI9, ISPG_NITHX;  
A6Q1U2, ISPG_NITSB;  Q3SVD0, ISPG_NITWN;  Q5YS74, ISPG_NOCFA;  
B2J1G1, ISPG_NOSP7;  P58666, ISPG_NOSS1;  A6WXY9, ISPG_OCHA4;  
B6JA27, ISPG_OLICO;  Q6K8J4, ISPG_ORYSJ;  A6LGR5, ISPG_PARD8;  
A1B323, ISPG_PARDP;  Q6MD85, ISPG_PARUW;  P57987, ISPG_PASMU;  
Q6D276, ISPG_PECAS;  C6DBH4, ISPG_PECCP;  Q4FNA0, ISPG_PELUB;  
C0QRI5, ISPG_PERMH;  Q7N706, ISPG_PHOLL;  Q6LU49, ISPG_PHOPR;  
Q7MVT7, ISPG_PORGI;  Q6A7L2, ISPG_PROAC;  Q7VBS7, ISPG_PROMA;  
B4EZT3, ISPG_PROMH;  Q7V7G9, ISPG_PROMM;  Q7V215, ISPG_PROMP;  
P72241, ISPG_PROST;  Q48LZ4, ISPG_PSE14;  A6V0W0, ISPG_PSEA7;  
B7UWI8, ISPG_PSEA8;  Q02RV7, ISPG_PSEAB;  Q9HXJ4, ISPG_PSEAE;  
Q1IEI1, ISPG_PSEE4;  Q4K6U9, ISPG_PSEF5;  C3K1L4, ISPG_PSEFS;  
Q3ICZ5, ISPG_PSEHT;  A4XY32, ISPG_PSEMY;  A5VYT5, ISPG_PSEP1;  
Q3K7B6, ISPG_PSEPF;  B0KPI7, ISPG_PSEPG;  Q88PJ7, ISPG_PSEPK;  
B1JDV8, ISPG_PSEPW;  Q886Z0, ISPG_PSESM;  Q4ZX23, ISPG_PSEU2;  
Q4FTW7, ISPG_PSYA2;  Q1QD18, ISPG_PSYCK;  A1SU39, ISPG_PSYIN;  
B2U9U9, ISPG_RALPJ;  P58669, ISPG_RALSO;  A9WR14, ISPG_RENSM;  
B3PR71, ISPG_RHIE6;  Q2K333, ISPG_RHIEC;  Q1MAC5, ISPG_RHIL3;  
Q98FG0, ISPG_RHILO;  B5ZUA0, ISPG_RHILW;  Q92L19, ISPG_RHIME;  
C3MAL6, ISPG_RHISN;  Q7UWC8, ISPG_RHOBA;  C1B2V4, ISPG_RHOOB;  
Q2J2S7, ISPG_RHOP2;  Q07V91, ISPG_RHOP5;  Q6NCF3, ISPG_RHOPA;  
Q21C20, ISPG_RHOPB;  B3QBC6, ISPG_RHOPT;  Q2RWE4, ISPG_RHORT;  
Q5LQ99, ISPG_RUEPO;  Q1GIC1, ISPG_RUEST;  A1AW46, ISPG_RUTMC;  
Q21KT3, ISPG_SACD2;  B5F198, ISPG_SALA4;  A8M723, ISPG_SALAI;  
A9MHL5, ISPG_SALAR;  Q57LI6, ISPG_SALCH;  B5FR63, ISPG_SALDC;  
B5R582, ISPG_SALEP;  B5RCZ2, ISPG_SALG2;  B4TD93, ISPG_SALHS;  
B4T0P9, ISPG_SALNS;  Q5PNI2, ISPG_SALPA;  A9N201, ISPG_SALPB;  
B5BAY5, ISPG_SALPK;  B4TR95, ISPG_SALSV;  P58670, ISPG_SALTI;  
A4X4L9, ISPG_SALTO;  P58671, ISPG_SALTY;  A8GHW5, ISPG_SERP5;  
A1S863, ISPG_SHEAM;  B8E9S7, ISPG_SHEB2;  A3D6V9, ISPG_SHEB5;  
A6WQP7, ISPG_SHEB8;  A9KXK8, ISPG_SHEB9;  Q12PT4, ISPG_SHEDO;  
Q085U6, ISPG_SHEFN;  B0TLI4, ISPG_SHEHH;  A3QCG2, ISPG_SHELP;  
Q8EC32, ISPG_SHEON;  A8H245, ISPG_SHEPA;  A4Y8U0, ISPG_SHEPC;  
B8CKR1, ISPG_SHEPW;  A0KUJ5, ISPG_SHESA;  A8FT70, ISPG_SHESH;  
Q0HKV9, ISPG_SHESM;  Q0HX57, ISPG_SHESR;  A1RHQ3, ISPG_SHESW;  
B1KKJ2, ISPG_SHEWM;  B2TXU0, ISPG_SHIB3;  Q31XX5, ISPG_SHIBS;  
Q32D47, ISPG_SHIDS;  Q0T204, ISPG_SHIF8;  Q83K43, ISPG_SHIFL;  
Q3YZ37, ISPG_SHISS;  A6UE79, ISPG_SINMW;  Q2NS40, ISPG_SODGM;  
Q029T9, ISPG_SOLUE;  B1VYP5, ISPG_STRGG;  B4SRZ0, ISPG_STRM5;  
B2FL74, ISPG_STRMK;  Q30TM4, ISPG_SULDN;  A6QC65, ISPG_SULNB;  
B2V7Y2, ISPG_SULSY;  Q67PA7, ISPG_SYMTH;  Q31QC4, ISPG_SYNE7;  
Q2JS69, ISPG_SYNJA;  Q2JPZ9, ISPG_SYNJB;  B1XHZ7, ISPG_SYNP2;  
Q5N3W3, ISPG_SYNP6;  Q7U712, ISPG_SYNPX;  Q0I9J4, ISPG_SYNS3;  
Q3AXP3, ISPG_SYNS9;  Q3AK30, ISPG_SYNSC;  P73672, ISPG_SYNY3;  
B7IFY1, ISPG_THEAB;  Q8DK70, ISPG_THEEB;  Q47RY0, ISPG_THEFY;  
A8F4Y8, ISPG_THELT;  Q9WZZ3, ISPG_THEMA;  A5IIP2, ISPG_THEP1;  
B1LC43, ISPG_THESQ;  Q72H18, ISPG_THET2;  Q5SLI8, ISPG_THET8;  
Q84GJ3, ISPG_THETH;  B5YIQ4, ISPG_THEYD;  Q73N90, ISPG_TREDE;  
O83460, ISPG_TREPA;  Q10W70, ISPG_TRIEI;  Q83NE4, ISPG_TROW8;  
Q83N18, ISPG_TROWT;  A5CX35, ISPG_VESOH;  A7MU42, ISPG_VIBCB;  
Q9KTX1, ISPG_VIBCH;  Q5E772, ISPG_VIBF1;  B5FAX2, ISPG_VIBFM;  
Q87S16, ISPG_VIBPA;  B7VJT8, ISPG_VIBSL;  Q8DEZ8, ISPG_VIBVU;  
Q7MNF1, ISPG_VIBVY;  Q8D1Y3, ISPG_WIGBR;  Q73IP1, ISPG_WOLPM;  
B3CNN4, ISPG_WOLPP;  Q7M8Z2, ISPG_WOLSU;  Q5GRK4, ISPG_WOLTR;  
C0R5E5, ISPG_WOLWR;  Q8PLJ8, ISPG_XANAC;  Q3BUK3, ISPG_XANC5;  
Q4UTW8, ISPG_XANC8;  B0RTS9, ISPG_XANCB;  Q8P9R7, ISPG_XANCP;  
Q2P3M7, ISPG_XANOM;  Q5H0N8, ISPG_XANOR;  Q9PAE3, ISPG_XYLFA;  
Q87A73, ISPG_XYLFT;  A1JKS2, ISPG_YERE8;  A7FFY9, ISPG_YERP3;  
Q1C5I8, ISPG_YERPA;  B2K9Q0, ISPG_YERPB;  P58672, ISPG_YERPE;  
A9R802, ISPG_YERPG;  Q1CK91, ISPG_YERPN;  A4TMT7, ISPG_YERPP;  
Q667Z9, ISPG_YERPS;  B1JS05, ISPG_YERPY;  Q5NR50, ISPG_ZYMMO;  

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