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ENZYME entry: EC 188.8.131.52
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|(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor <=> (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor|
- Requires ATP.
- The reaction in mammals possibly involves dehydrogenation to give a
24(25)-double bond followed by hydration.
- However, in amphibians such as the Oriental fire-bellied toad
(Bombina orientalis), it is probable that the product is formed via
direct hydroxylation of the saturated side chain of (25R)-3-alpha,7-
alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate and not via
hydration of a 24(25) double bond.
- In microsomes, the free acid is preferred to the coenzyme A ester,
whereas in mitochondria, the coenzyme A ester is preferred to the
free-acid form of the substrate.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
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