ENZYME entry: EC 1.2.1.76

Accepted Name
Succinate-semialdehyde dehydrogenase (acetylating).
Alternative Name(s)
Coenzyme-A-dependent succinate-semialdehyde dehydrogenase.
Succinyl-CoA reductase.
Reaction catalysed
Succinate semialdehyde + CoA + NADP(+) <=> succinyl-CoA + NADPH
Comment(s)
  • Catalyzes the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
  • The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation, and in Metallosphaera sedula, where it participates in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
Cross-references
PROSITEPDOC00058
BRENDA1.2.1.76
EC2PDB1.2.1.76
ExplorEnz1.2.1.76
PRIAM enzyme-specific profiles1.2.1.76
KEGG Ligand Database for Enzyme Nomenclature1.2.1.76
IUBMB Enzyme Nomenclature1.2.1.76
IntEnz1.2.1.76
MEDLINEFind literature relating to 1.2.1.76
MetaCyc1.2.1.76
UniProtKB/Swiss-Prot
P38947, SUCD_CLOK5;  A4YGN0, SUCD_METS5;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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