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ENZYME entry: EC

Accepted Name
Succinate-semialdehyde dehydrogenase (acetylating).
Alternative Name(s)
Coenzyme-A-dependent succinate-semialdehyde dehydrogenase.
Succinyl-CoA reductase.
Reaction catalysed
Succinate semialdehyde + CoA + NADP(+) <=> succinyl-CoA + NADPH
  • Catalyzes the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
  • The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation, and in Metallosphaera sedula, where it participates in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
PRIAM enzyme-specific profiles1.2.1.76
KEGG Ligand Database for Enzyme Nomenclature1.2.1.76
IUBMB Enzyme Nomenclature1.2.1.76
MEDLINEFind literature relating to
P38947, SUCD_CLOK5;  A4YGN0, SUCD_METS5;  

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