ENZYME entry: EC 1.2.3.3
| Accepted Name |
|---|
| Pyruvate oxidase.
|
| Alternative Name(s) |
|---|
| Phosphate-dependent pyruvate oxidase. |
| Pyruvic oxidase. |
| Reaction catalysed |
|---|
| Pyruvate + phosphate + O(2) <=> acetyl phosphate + CO(2) + H(2)O(2) |
| Cofactor(s) |
|---|
| FAD; Thiamine diphosphate.
|
| Comment(s) |
|---|
- Two reducing equivalents are transferred from the resonant
carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the
adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate
(AcThDP) and reduced flavin.
- FADH is reoxidized by O(2) to yield H(2)O(2) and FAD and AcThDP is
cleaved phosphorolytically to acetyl phosphate and thiamine
diphosphate.
|
| Cross-references |
|---|
| PROSITE | PDOC00166 |
| BRENDA | 1.2.3.3 |
| EC2PDB | 1.2.3.3 |
| ExplorEnz | 1.2.3.3 |
| PRIAM enzyme-specific profiles | 1.2.3.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.3.3 |
| IUBMB Enzyme Nomenclature | 1.2.3.3 |
| IntEnz | 1.2.3.3 |
| MEDLINE | Find literature relating to 1.2.3.3 |
| MetaCyc | 1.2.3.3 |
| UniProtKB/Swiss-Prot |
|
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