To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.2.7.4

Accepted Name
Anaerobic carbon-monoxide dehydrogenase.
Alternative Name(s)
Carbon-monoxide dehydrogenase (ferredoxin).
Ni-CODH.
Reaction catalysed
CO + H(2)O + 2 oxidized ferredoxin <=> CO(2) + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Fe cation; Ni(2+); Zn(2+).
Comment(s)
  • This prokaryotic enzyme catalyzes the reversible reduction of CO(2) to CO.
  • The electrons are transferred to redox proteins such as ferredoxin.
  • In purple sulfur bacteria and methanogenic archaea it catalyzes the oxidation of CO to CO(2), which is incorporated by the Calvin-Benson- Basham cycle or released, respectively.
  • In acetogenic and sulfate-reducing microbes it catalyzes the reduction of CO(2) to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, with which the enzyme forms a tight complex in those organisms.
  • In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O = CO(2) + H(2).
  • Cf. EC 1.2.5.3.
  • Formerly EC 1.2.99.2.
Cross-references
BRENDA1.2.7.4
EC2PDB1.2.7.4
ExplorEnz1.2.7.4
PRIAM enzyme-specific profiles1.2.7.4
KEGG Ligand Database for Enzyme Nomenclature1.2.7.4
IUBMB Enzyme Nomenclature1.2.7.4
IntEnz1.2.7.4
MEDLINEFind literature relating to 1.2.7.4
MetaCyc1.2.7.4
UniProtKB/Swiss-Prot
O29165, ACDA1_ARCFU;  Q8TRZ4, ACDA1_METAC;  Q46G04, ACDA1_METBF;  
Q8TXF7, ACDA1_METKA;  Q49161, ACDA1_METMA;  Q08368, ACDA1_METTE;  
O30274, ACDA2_ARCFU;  Q8TJC6, ACDA2_METAC;  Q49163, ACDA2_METMA;  
Q9C4Z4, ACDA2_METTE;  Q8THW2, ACDA3_METAC;  Q12XL7, ACDA_METBU;  
P26692, ACDA_METCN;  Q57617, ACDA_METJA;  O27743, ACDA_METTH;  
P59934, COOS1_CARHZ;  Q8TKW2, COOS1_METAC;  Q8Q0L5, COOS1_METMA;  
Q9F8A8, COOS2_CARHZ;  Q8TR73, COOS2_METAC;  Q8PUN1, COOS2_METMA;  
O28429, COOS_ARCFU;  Q58138, COOS_METJA;  Q8TXX3, COOS_METKA;  
P31896, COOS_RHORU;  P27989, DCMB_MOOTH;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-