ENZYME entry: EC 1.2.7.4

Accepted Name
Anaerobic carbon-monoxide dehydrogenase.
Alternative Name(s)
Carbon-monoxide dehydrogenase (ferredoxin).
Ni-CODH.
Reaction catalysed
CO + H(2)O + 2 oxidized ferredoxin <=> CO(2) + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Fe cation; Ni(2+); Zn(2+).
Comment(s)
  • This prokaryotic enzyme catalyzes the reversible reduction of CO(2) to CO.
  • The electrons are transferred to redox proteins such as ferredoxin.
  • In purple sulfur bacteria and methanogenic archaea it catalyzes the oxidation of CO to CO(2), which is incorporated by the Calvin-Benson- Basham cycle or released, respectively.
  • In acetogenic and sulfate-reducing microbes it catalyzes the reduction of CO(2) to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, with which the enzyme forms a tight complex in those organisms.
  • In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O = CO(2) + H(2).
  • Cf. EC 1.2.5.3.
Cross-references
BRENDA1.2.7.4
EC2PDB1.2.7.4
ExplorEnz1.2.7.4
PRIAM enzyme-specific profiles1.2.7.4
KEGG Ligand Database for Enzyme Nomenclature1.2.7.4
IUBMB Enzyme Nomenclature1.2.7.4
IntEnz1.2.7.4
MEDLINEFind literature relating to 1.2.7.4
MetaCyc1.2.7.4
UniProtKB/Swiss-Prot
P27989, DCMB_MOOTH

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