ENZYME

ENZYME entry: EC 2.3.1.169

Accepted Name

CO-methylating acetyl-CoA synthase.

Alternative Name(s)

ACS.

Reaction catalysed

Acetyl-CoA + corrinoid protein <=> CO + methylcorrinoid protein + CoA

Cofactor(s)

Iron-sulfur; Nickel.

Comment(s)

Also catalyzes exchange reactions of carbon between C-1 of acetyl-CoA and CO, and between C-2 of acetyl-CoA and methyl corrinoid protein.
Involved, together with EC 1.2.7.4, in the synthesis of acetyl-CoA from CO(2) and H(2).
To follow its stoichiometry, the reaction can be written as: CH(3)- CO-S-CoA + protein Co(+) + H(+) = CO + protein Co(2+)-CH(3) + HS-CoA.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature