ENZYME entry: EC 2.3.1.169

Accepted Name
CO-methylating acetyl-CoA synthase.
Alternative Name(s)
ACS.
Reaction catalysed
Acetyl-CoA + corrinoid protein <=> CO + methylcorrinoid protein + CoA
Cofactor(s)
Iron-sulfur; Nickel.
Comment(s)
  • Also catalyzes exchange reactions of carbon between C-1 of acetyl-CoA and CO, and between C-2 of acetyl-CoA and methyl corrinoid protein.
  • Involved, together with EC 1.2.7.4, in the synthesis of acetyl-CoA from CO(2) and H(2).
  • To follow its stoichiometry, the reaction can be written as: CH(3)- CO-S-CoA + protein Co(+) + H(+) = CO + protein Co(2+)-CH(3) + HS-CoA.
Cross-references
BRENDA2.3.1.169
EC2PDB2.3.1.169
ExplorEnz2.3.1.169
PRIAM enzyme-specific profiles2.3.1.169
KEGG Ligand Database for Enzyme Nomenclature2.3.1.169
IUBMB Enzyme Nomenclature2.3.1.169
IntEnz2.3.1.169
MEDLINEFind literature relating to 2.3.1.169
MetaCyc2.3.1.169
UniProtKB/Swiss-Prot
P27988, DCMA_MOOTH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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