ENZYME entry: EC 1.21.3.7

Accepted Name
Tetrahydrocannabinolic acid synthase.
Alternative Name(s)
Delta(1)-tetrahydrocannabinolic acid synthase.
THCA synthase.
Reaction catalysed
Cannabigerolate + O(2) <=> Delta(9)-tetrahydrocannabinolate + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • The cofactor is covalently bound.
  • Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
  • The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency.
  • The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate.
  • Systematic peripheral numbering is now recommended.
Cross-references
BRENDA1.21.3.7
EC2PDB1.21.3.7
ExplorEnz1.21.3.7
PRIAM enzyme-specific profiles1.21.3.7
KEGG Ligand Database for Enzyme Nomenclature1.21.3.7
IUBMB Enzyme Nomenclature1.21.3.7
IntEnz1.21.3.7
MEDLINEFind literature relating to 1.21.3.7
MetaCyc1.21.3.7
UniProtKB/Swiss-Prot
Q8GTB6, THCAS_CANSA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.3.-
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