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ENZYME entry: EC 1.3.99.8

Accepted Name
2-furoyl-CoA dehydrogenase.
Alternative Name(s)
Furoyl-CoA hydroxylase.
Reaction catalysed
2-furoyl-CoA + H(2)O + acceptor <=> S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
Cofactor(s)
Cu cation.
Comment(s)
  • The oxygen atom of the -OH produced is derived from water, not O(2).
  • The actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH(2)- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH(2)-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA.
  • Methylene blue, nitro blue tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.
Cross-references
BRENDA1.3.99.8
EC2PDB1.3.99.8
ExplorEnz1.3.99.8
PRIAM enzyme-specific profiles1.3.99.8
KEGG Ligand Database for Enzyme Nomenclature1.3.99.8
IUBMB Enzyme Nomenclature1.3.99.8
IntEnz1.3.99.8
MEDLINEFind literature relating to 1.3.99.8
MetaCyc1.3.99.8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.99.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-