ENZYME entry: EC 1.4.1.21

Accepted Name
Aspartate dehydrogenase.
Alternative Name(s)
NAD-dependent aspartate dehydrogenase.
NADH(2)-dependent aspartate dehydrogenase.
NADP(+)-dependent aspartate dehydrogenase.
Reaction catalysed
L-aspartate + H(2)O + NAD(P)(+) <=> oxaloacetate + NH(3) + NAD(P)H
Comment(s)
  • Catalyzes the first step in NAD biosynthesis from aspartate.
  • Strictly specific for L-aspartate as substrate.
  • Has a higher affinity for NAD(+) than NADP(+).
Cross-references
BRENDA1.4.1.21
EC2PDB1.4.1.21
ExplorEnz1.4.1.21
PRIAM enzyme-specific profiles1.4.1.21
KEGG Ligand Database for Enzyme Nomenclature1.4.1.21
IUBMB Enzyme Nomenclature1.4.1.21
IntEnz1.4.1.21
MEDLINEFind literature relating to 1.4.1.21
MetaCyc1.4.1.21
UniProtKB/Swiss-Prot
Q7WQR6, ASPD1_BORBR;  Q7W1T9, ASPD1_BORPA;  Q7VS76, ASPD1_BORPE;  
Q7WLJ8, ASPD2_BORBR;  Q7W850, ASPD2_BORPA;  Q7VX83, ASPD2_BORPE;  
Q7WE57, ASPD3_BORBR;  Q6FDH0, ASPD_ACIAD;  B7GY04, ASPD_ACIB3;  
B7I8C4, ASPD_ACIB5;  B2HVA8, ASPD_ACIBC;  A3M394, ASPD_ACIBT;  
B0V9I9, ASPD_ACIBY;  O28440, ASPD_ARCFU;  Q89FY1, ASPD_BRAJA;  
A3MD35, ASPD_BURM7;  A2RXI5, ASPD_BURM9;  Q62BI3, ASPD_BURMA;  
A1UVC0, ASPD_BURMS;  A3P4L6, ASPD_BURP0;  Q3JFK2, ASPD_BURP1;  
A3NIZ0, ASPD_BURP6;  Q63LV9, ASPD_BURPS;  Q397Y5, ASPD_BURS3;  
Q2T559, ASPD_BURTA;  Q0K391, ASPD_CUPNH;  B3R8S4, ASPD_CUPTR;  
Q66I59, ASPD_DANRE;  A6ND91, ASPD_HUMAN;  A6UVA8, ASPD_META3;  
Q8TS47, ASPD_METAC;  Q46BD6, ASPD_METBF;  Q12VF1, ASPD_METBU;  
Q2FSK9, ASPD_METHJ;  Q58325, ASPD_METJA;  Q8TZ45, ASPD_METKA;  
A4FY69, ASPD_METM5;  A9A7M3, ASPD_METM6;  A6VK38, ASPD_METM7;  
Q8PV99, ASPD_METMA;  Q6LZ92, ASPD_METMP;  O27054, ASPD_METTH;  
A6USM7, ASPD_METVS;  Q9DCQ2, ASPD_MOUSE;  A9A1F7, ASPD_NITMS;  
A6X792, ASPD_OCHA4;  Q126F5, ASPD_POLSJ;  Q9HYA4, ASPD_PSEAE;  
Q1QBB6, ASPD_PSYCK;  B2UJ42, ASPD_RALPJ;  Q8XRV9, ASPD_RALSO;  
Q5I0J9, ASPD_RAT;  Q5LPG8, ASPD_RUEPO;  A8GIW3, ASPD_SERP5;  
Q9X1X6, ASPD_THEMA;  B1LB32, ASPD_THESQ;  Q0W7E0, ASPD_UNCMA;  
Q5FW48, ASPD_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.1.-
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