ENZYME entry: EC 1.5.1.20

Accepted Name
Methylenetetrahydrofolate reductase (NAD(P)H).
Alternative Name(s)
5,10-CH(2)-H(4)folate reductase.
5,10-methylenetetrahydrofolate reductase.
5,10-methylenetetrahydrofolate reductase (FADH(2)).
5,10-methylenetetrahydrofolate reductase (NADPH).
5,10-methylenetetrahydrofolic acid reductase.
5,10-methylenetetrahydropteroylglutamate reductase.
5-methyltetrahydrofolate:(acceptor) oxidoreductase.
5-methyltetrahydrofolate:NAD oxidoreductase.
5-methyltetrahydrofolate:NAD(+) oxidoreductase.
5-methyltetrahydrofolate:NADP(+) oxidoreductase.
Methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase.
Methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase.
Methylenetetrahydrofolate reductase.
Methylenetetrahydrofolate reductase (NADPH(2)).
Methylenetetrahydrofolate reductase (NADPH).
Methylenetetrahydrofolic acid reductase.
MTHFR.
N(5),N(10)-methylenetetrahydrofolate reductase.
N(5,10)-methylenetetrahydrofolate reductase.
Reaction catalysed
5-methyltetrahydrofolate + NAD(P)(+) <=> 5,10-methylenetetrahydrofolate + NAD(P)H
Cofactor(s)
FAD.
Comment(s)
Cross-references
BRENDA1.5.1.20
EC2PDB1.5.1.20
ExplorEnz1.5.1.20
PRIAM enzyme-specific profiles1.5.1.20
KEGG Ligand Database for Enzyme Nomenclature1.5.1.20
IUBMB Enzyme Nomenclature1.5.1.20
IntEnz1.5.1.20
MEDLINEFind literature relating to 1.5.1.20
MetaCyc1.5.1.20
UniProtKB/Swiss-Prot
O67422, METF_AQUAE;  P57154, METF_BUCAI;  Q8KA62, METF_BUCAP;  
Q89B13, METF_BUCBP;  P0AEZ1, METF_ECOLI;  P45208, METF_HAEIN;  
Q9JZQ3, METF_NEIMB;  P71319, METF_PECCC;  P11003, METF_SALTY;  
P0AEZ2, METF_SHIFL;  O54235, METF_STRLI;  Q9SE60, MTHR1_ARATH;  
Q9SE94, MTHR1_MAIZE;  Q10258, MTHR1_SCHPO;  P46151, MTHR1_YEAST;  
O80585, MTHR2_ARATH;  O74927, MTHR2_SCHPO;  P53128, MTHR2_YEAST;  
Q5I598, MTHR_BOVIN;  Q17693, MTHR_CAEEL;  P42898, MTHR_HUMAN;  
Q60HE5, MTHR_MACFA;  Q9WU20, MTHR_MOUSE;  Q75HE6, MTHR_ORYSJ;  
O06745, YITJ_BACSU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
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