ENZYME entry: EC 1.5.1.3

Accepted Name
Dihydrofolate reductase.
Alternative Name(s)
Tetrahydrofolate dehydrogenase.
Reaction catalysed
5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH
Comment(s)
  • The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
  • Formerly EC 1.5.1.4.
Cross-references
PROSITEPDOC00072
BRENDA1.5.1.3
EC2PDB1.5.1.3
ExplorEnz1.5.1.3
PRIAM enzyme-specific profiles1.5.1.3
KEGG Ligand Database for Enzyme Nomenclature1.5.1.3
IUBMB Enzyme Nomenclature1.5.1.3
IntEnz1.5.1.3
MEDLINEFind literature relating to 1.5.1.3
MetaCyc1.5.1.3
UniProtKB/Swiss-Prot
Q05762, DRTS1_ARATH;  Q05763, DRTS2_ARATH;  Q23695, DRTS_CRIFA;  
P45350, DRTS_DAUCA;  P16126, DRTS_LEIAM;  P07382, DRTS_LEIMA;  
O81395, DRTS_MAIZE;  Q5UQG3, DRTS_MIMIV;  Q2QRX6, DRTS_ORYSJ;  
Q27828, DRTS_PARTE;  Q27713, DRTS_PLABA;  P20712, DRTS_PLACH;  
P13922, DRTS_PLAFK;  O02604, DRTS_PLAVI;  P46103, DRTS_PLAVN;  
P51820, DRTS_SOYBN;  Q07422, DRTS_TOXGO;  Q27783, DRTS_TRYBB;  
Q27793, DRTS_TRYCR;  Q04515, DYR10_ECOLX;  Q59408, DYR13_ECOLX;  
P78218, DYR15_ECOLX;  P00382, DYR1_ECOLX;  Q5V3R2, DYR1_HALMA;  
P00383, DYR21_ECOLX;  P00384, DYR22_ECOLX;  P05794, DYR23_ECOLX;  
Q5V600, DYR2_HALMA;  P12833, DYR3_SALTM;  P11731, DYR5_ECOLX;  
P95524, DYR6_PROMI;  P27422, DYR7_ECOLX;  P0ABQ7, DYR8_ECOLX;  
P0ABQ8, DYR8_SHISO;  Q59397, DYR9_ECOLX;  P13955, DYRA_STAAU;  
Q86XF0, DYRL1_HUMAN;  P28019, DYR_AEDAL;  P11045, DYR_BACSU;  
P00376, DYR_BOVIN;  P04382, DYR_BPT4;  P57243, DYR_BUCAI;  
Q8K9Z8, DYR_BUCAP;  Q89AV2, DYR_BUCBP;  Q93341, DYR_CAEEL;  
P22906, DYR_CANAX;  P00378, DYR_CHICK;  P31073, DYR_CITFR;  
Q07801, DYR_CRYNJ;  P17719, DYR_DROME;  P0ABQ5, DYR_ECOL6;  
P0ABQ4, DYR_ECOLI;  O62583, DYR_ENCCU;  P31074, DYR_ENTAE;  
P00380, DYR_ENTFC;  P43791, DYR_HAEIN;  P15093, DYR_HALVD;  
Q9U8B8, DYR_HELVI;  Q2HRC6, DYR_HHV8P;  P00374, DYR_HUMAN;  
P00381, DYR_LACCA;  Q59487, DYR_LACLA;  P04753, DYR_MESAU;  
P00375, DYR_MOUSE;  P0A547, DYR_MYCBO;  P47470, DYR_MYCGE;  
Q9CBW1, DYR_MYCLE;  P78028, DYR_MYCPN;  Q98Q32, DYR_MYCPU;  
P9WNX0, DYR_MYCTO;  P9WNX1, DYR_MYCTU;  P04174, DYR_NEIGO;  
Q9JSQ9, DYR_NEIMA;  Q9K168, DYR_NEIMB;  P00377, DYR_PIG;  
P16184, DYR_PNECA;  Q920D2, DYR_RAT;  P36591, DYR_SCHPO;  
P0ABQ6, DYR_SHIFL;  P09503, DYR_SHV21;  P27421, DYR_SHV24;  
P22573, DYR_SHV2C;  Q5HFZ7, DYR_STAAC;  P0A016, DYR_STAAM;  
P99079, DYR_STAAN;  Q6GGY1, DYR_STAAR;  Q6G9D5, DYR_STAAS;  
P0A017, DYR_STAAU;  Q8NWQ9, DYR_STAAW;  P0C0P0, DYR_STAEP;  
Q5HPB1, DYR_STAEQ;  P0C0P1, DYR_STAES;  Q54277, DYR_STAHA;  
Q54801, DYR_STRPN;  Q60034, DYR_THEMA;  Q9PR30, DYR_UREPA;  
P07807, DYR_YEAST;  A8AGY5, FOLM_CITK8;  A7ZM66, FOLM_ECO24;  
P0AFS4, FOLM_ECO57;  A8A0E8, FOLM_ECOHS;  A1ABF1, FOLM_ECOK1;  
Q0THM2, FOLM_ECOL5;  Q8FHB1, FOLM_ECOL6;  B1IQY4, FOLM_ECOLC;  
P0AFS3, FOLM_ECOLI;  B1LET0, FOLM_ECOSM;  Q1RBJ2, FOLM_ECOUT;  
A4W9Z4, FOLM_ENT38;  A6T8N3, FOLM_KLEP7;  Q320W2, FOLM_SHIBS;  
Q32G72, FOLM_SHIDS;  Q0T4H1, FOLM_SHIF8;  Q83RC9, FOLM_SHIFL;  
Q3Z1V9, FOLM_SHISS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-