To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.5.3.6

Accepted Name
(R)-6-hydroxynicotine oxidase.
Alternative Name(s)
6-hydroxy-D-nicotine oxidase.
D-6-hydroxynicotine oxidase.
Reaction catalysed
(R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)- nicotine.
  • The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the (S)-isomer (cf. EC 1.5.3.5).
Cross-references
PROSITEPDOC00674
BRENDA1.5.3.6
EC2PDB1.5.3.6
ExplorEnz1.5.3.6
PRIAM enzyme-specific profiles1.5.3.6
KEGG Ligand Database for Enzyme Nomenclature1.5.3.6
IUBMB Enzyme Nomenclature1.5.3.6
IntEnz1.5.3.6
MEDLINEFind literature relating to 1.5.3.6
MetaCyc1.5.3.6
UniProtKB/Swiss-Prot
P08159, HDNO_PSEOX

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-