ENZYME entry: EC 1.5.3.6

Accepted Name
(R)-6-hydroxynicotine oxidase.
Alternative Name(s)
6-hydroxy-D-nicotine oxidase.
D-6-hydroxynicotine oxidase.
Reaction catalysed
(R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)- nicotine.
  • The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the (S)-isomer (cf. EC 1.5.3.5).
Cross-references
PROSITEPDOC00674
BRENDA1.5.3.6
EC2PDB1.5.3.6
ExplorEnz1.5.3.6
PRIAM enzyme-specific profiles1.5.3.6
KEGG Ligand Database for Enzyme Nomenclature1.5.3.6
IUBMB Enzyme Nomenclature1.5.3.6
IntEnz1.5.3.6
MEDLINEFind literature relating to 1.5.3.6
MetaCyc1.5.3.6
UniProtKB/Swiss-Prot
P08159, HDNO_ARTOX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
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