ENZYME entry: EC 1.8.1.12
| Accepted Name |
|---|
| Trypanothione-disulfide reductase.
|
| Alternative Name(s) |
|---|
| N(1),N(8)-bis(glutathionyl)spermidine reductase. |
| NADPH:trypanothione oxidoreductase. |
| Trypanothione reductase. |
| Reaction catalysed |
|---|
| Trypanothione + NADP(+) <=> trypanothione disulfide + NADPH |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- Trypanothione disulfide is the oxidized form of N(1),N(8)-
bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid
Crithidia fasciculata.
- The activity is dependent on a redox-active cystine at the active
center (cf. EC 1.8.1.7).
- Formerly EC 1.6.4.8.
|
| Cross-references |
|---|
| PROSITE | PDOC00073 |
| BRENDA | 1.8.1.12 |
| EC2PDB | 1.8.1.12 |
| ExplorEnz | 1.8.1.12 |
| PRIAM enzyme-specific profiles | 1.8.1.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.8.1.12 |
| IUBMB Enzyme Nomenclature | 1.8.1.12 |
| IntEnz | 1.8.1.12 |
| MEDLINE | Find literature relating to 1.8.1.12 |
| MetaCyc | 1.8.1.12 |
| UniProtKB/Swiss-Prot |
|
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