ENZYME entry: EC 1.97.1.11
| Accepted Name |
|---|
| Thyroxine 5-deiodinase.
|
| Alternative Name(s) |
|---|
| Diiodothyronine 5'-deiodinase. |
| Iodothyronine 5-deiodinase. |
| Iodothyronine inner ring monodeiodinase. |
| Type III iodothyronine deiodinase. |
| Reaction catalysed |
|---|
| 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) <=> L-thyroxine + AH(2) |
| Comment(s) |
|---|
- The enzyme activity has only been demonstrated in the direction of
5-deiodination.
- This removal of the 5-iodine, i.e. from the inner ring, largely
inactivates the hormone thyroxine.
|
| Cross-references |
|---|
| PROSITE | PDOC00172 ; PDOC00925 |
| BRENDA | 1.97.1.11 |
| EC2PDB | 1.97.1.11 |
| ExplorEnz | 1.97.1.11 |
| PRIAM enzyme-specific profiles | 1.97.1.11 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.97.1.11 |
| IUBMB Enzyme Nomenclature | 1.97.1.11 |
| IntEnz | 1.97.1.11 |
| MEDLINE | Find literature relating to 1.97.1.11 |
| MetaCyc | 1.97.1.11 |
| UniProtKB/Swiss-Prot |
| Q5I3B1, IOD3_BOVIN; | O42412, IOD3_CHICK; | P55073, IOD3_HUMAN; |
| P49898, IOD3_LITCT; | Q91ZI8, IOD3_MOUSE; | Q6QN11, IOD3_PIG; |
| P49897, IOD3_RAT; | Q6DN07, IOD3_SHEEP; | A7YD35, IOD3_SPAAU; |
| P49899, IOD3_XENLA; |
|
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