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ENZYME

ENZYME entry: EC 2.1.1.106

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.106
Accepted Name
tryptophan 2-C-methyltransferase
Alternative Name(s)
tryptophan 2-methyltransferase
Reaction catalysed
L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis.
  • It is a radical SAM enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor.
  • It has an exceptional reaction mechanism as the S-adenosyl-L- methionine (SAM) is not bound to the [4Fe-4S] center and does not produce a 5'-deoxyadenosyl radical but instead is believed to be involved in binding of the L-tryptophan substrate.
  • After transfer of the methyl group from methylcob(III)alaminIn a methyl transfer from SAM to the generated cob(I)alamin takes place, preparing the enzyme for the next catalytic cycle.
  • The original methyl group configuration is preserved.
Cross-references
BRENDA2.1.1.106
EC2PDB2.1.1.106
ExplorEnz2.1.1.106
KEGG Ligand Database for Enzyme Nomenclature2.1.1.106
IUBMB Enzyme Nomenclature2.1.1.106
MEDLINEFind literature relating to 2.1.1.106
MetaCyc2.1.1.106
Rhea expert-curated reactions2.1.1.106
UniProtKB/Swiss-Prot
C0JRZ9, TSRM_STRLU

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