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ENZYME entry: EC

Accepted Name
Tryptophan 2-C-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + L-tryptophan <=> S-adenosyl-L-homocysteine + L-2-methyltryptophan
  • The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis.
  • It is a radical SAM enzyme that contains a [4Fe-4S] center and a cobalamin cofactor.
  • The enzyme first transfers the methyl group from SAM to the bound cobalamin, followed by transfer from methylcobalamin to L-tryptophan, resulting in retention of the original methyl group configuration.
  • The second transfer is likely to involve a CH(3) radical species formed from methylcobalamin by the concerted action of a partially ligated radical SAM [4Fe-4S](2+/1+) center.
PRIAM enzyme-specific profiles2.1.1.106
KEGG Ligand Database for Enzyme Nomenclature2.1.1.106
IUBMB Enzyme Nomenclature2.1.1.106
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