ENZYME entry: EC 2.1.1.125

Accepted Name
Histone-arginine N-methyltransferase.
Alternative Name(s)
Histone protein methylase.
Protein methylase I.
Protein-arginine N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + arginine-[histone] <=> S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]
Comment(s)
  • Forms the N(omega)-monomethyl- and N(omega),N(omega')-dimethyl, but not the N(omega),N(omega)-dimethyl-arginine derivatives.
  • The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities.
  • Formerly EC 2.1.1.23.
Cross-references
BRENDA2.1.1.125
EC2PDB2.1.1.125
ExplorEnz2.1.1.125
PRIAM enzyme-specific profiles2.1.1.125
KEGG Ligand Database for Enzyme Nomenclature2.1.1.125
IUBMB Enzyme Nomenclature2.1.1.125
IntEnz2.1.1.125
MEDLINEFind literature relating to 2.1.1.125
MetaCyc2.1.1.125
UniProtKB/Swiss-Prot
Q9MAT5, ANM10_ARATH;  A2Y953, ANM10_ORYSI;  Q9SNQ2, ANM10_ORYSJ;  
Q9SU94, ANM11_ARATH;  Q84W92, ANM13_ARATH;  A3KPF2, ANM14_ARATH;  
Q8GWT4, ANM15_ARATH;  Q8AV13, ANM1A_XENLA;  Q6VRB0, ANM1B_XENLA;  
Q54EF2, ANM1_DICDI;  Q99873, ANM1_HUMAN;  Q9JIF0, ANM1_MOUSE;  
Q63009, ANM1_RAT;  Q28F07, ANM1_XENTR;  Q54HI0, ANM2_DICDI;  
P55345, ANM2_HUMAN;  Q9R144, ANM2_MOUSE;  D9IVE5, ANM2_XENLA;  
B3DLB3, ANM2_XENTR;  A7YW45, ANM5_BOVIN;  P46580, ANM5_CAEEL;  
Q54KI3, ANM5_DICDI;  O14744, ANM5_HUMAN;  Q4R5M3, ANM5_MACFA;  
Q8CIG8, ANM5_MOUSE;  A2X0Q3, ANM5_ORYSI;  Q6YXZ7, ANM5_ORYSJ;  
Q5R698, ANM5_PONAB;  Q6NUA1, ANM5_XENLA;  Q5E9L5, ANM6_BOVIN;  
Q6NWG4, ANM6_DANRE;  Q96LA8, ANM6_HUMAN;  Q6NZB1, ANM6_MOUSE;  
Q68EZ3, ANM6_XENLA;  B0JYW5, ANM6_XENTR;  A6QQV6, ANM7_BOVIN;  
Q5ZIB9, ANM7_CHICK;  Q99MI9, ANM7_CRILO;  A2AV36, ANM7_DANRE;  
Q9NVM4, ANM7_HUMAN;  Q922X9, ANM7_MOUSE;  Q5U4E8, ANM7_RAT;  
Q6PCI6, ANM7_XENLA;  Q174R2, CARM1_AEDAE;  Q7Q2B7, CARM1_ANOGA;  
B0W3L6, CARM1_CULQU;  Q6DC04, CARM1_DANRE;  B3M1E1, CARM1_DROAN;  
B3P4N5, CARM1_DROER;  B4JXV2, CARM1_DROGR;  Q9VH48, CARM1_DROME;  
B4KA23, CARM1_DROMO;  B4GZ20, CARM1_DROPE;  Q29B63, CARM1_DROPS;  
B4HJC0, CARM1_DROSE;  B4QVW6, CARM1_DROSI;  B4LVS8, CARM1_DROVI;  
B4NKI9, CARM1_DROWI;  B4PVH6, CARM1_DROYA;  Q86X55, CARM1_HUMAN;  
Q9WVG6, CARM1_MOUSE;  A2YPT7, CARM1_ORYSI;  Q7XI75, CARM1_ORYSJ;  
Q4AE70, CARM1_RAT;  Q5XK84, CARM1_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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