ENZYME

ENZYME entry: EC 2.1.1.137

Accepted Name

Arsenite methyltransferase.

Alternative Name(s)

Methylarsonite methyltransferase.

S-adenosyl-L-methionine:arsenic(III) methyltransferase.

S-adenosyl-L-methionine:methylarsonite As-methyltransferase.

Reaction catalysed

S-adenosyl-L-methionine + arsenite <=> S-adenosyl-L-homocysteine + methylarsonate
S-adenosyl-L-methionine + methylarsonite <=> S-adenosyl-L-homocysteine + dimethylarsinate

Comment(s)

An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.
It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by EC 1.20.4.2 to methylarsonite, Me-As(OH)(2).
Methylarsonite is also a substrate for this enzyme which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature