ENZYME entry: EC 2.1.1.164

Accepted Name
Demethylrebeccamycin-D-glucose O-methyltransferase.
Reaction catalysed
4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> rebeccamycin + S-adenosyl-L-homocysteine
Comment(s)
  • Catalyzes the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers.
Cross-references
BRENDA2.1.1.164
EC2PDB2.1.1.164
ExplorEnz2.1.1.164
PRIAM enzyme-specific profiles2.1.1.164
KEGG Ligand Database for Enzyme Nomenclature2.1.1.164
IUBMB Enzyme Nomenclature2.1.1.164
IntEnz2.1.1.164
MEDLINEFind literature relating to 2.1.1.164
MetaCyc2.1.1.164
UniProtKB/Swiss-Prot
Q8KZ94, REBMT_NOCAE

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