ENZYME entry: EC 2.1.1.190

Accepted Name
23S rRNA (uracil(1939)-C(5))-methyltransferase.
Alternative Name(s)
RNA uridine methyltransferase A.
Reaction catalysed
S-adenosyl-L-methionine + uracil(1939) in 23S rRNA <=> S-adenosyl-L-homocysteine + 5-methyluracil(1939) in 23S rRNA
Comment(s)
  • The enzyme specifically methylates uracil(1939) at C(5) in 23S rRNA.
  • The enzyme contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues.
Cross-references
BRENDA2.1.1.190
EC2PDB2.1.1.190
ExplorEnz2.1.1.190
PRIAM enzyme-specific profiles2.1.1.190
KEGG Ligand Database for Enzyme Nomenclature2.1.1.190
IUBMB Enzyme Nomenclature2.1.1.190
IntEnz2.1.1.190
MEDLINEFind literature relating to 2.1.1.190
MetaCyc2.1.1.190
UniProtKB/Swiss-Prot
O31503, RLMCD_BACSU;  A1TSE0, RLMD_ACIAC;  Q6F847, RLMD_ACIAD;  
B7H018, RLMD_ACIB3;  B7I675, RLMD_ACIB5;  B2HTF7, RLMD_ACIBC;  
B0VKL3, RLMD_ACIBS;  B0V5N2, RLMD_ACIBY;  B7J921, RLMD_ACIF2;  
B5EPA4, RLMD_ACIF5;  A1W8J9, RLMD_ACISJ;  A0KGG9, RLMD_AERHH;  
A4SRC5, RLMD_AERS4;  Q0VP26, RLMD_ALCBS;  B6EKM3, RLMD_ALISL;  
Q0A8Y4, RLMD_ALKEH;  F2GA29, RLMD_ALTMD;  F5ZEI8, RLMD_ALTNA;  
Q5P841, RLMD_AROAE;  A1K4G2, RLMD_AZOSB;  Q2L016, RLMD_BORA1;  
Q7WI42, RLMD_BORBR;  Q7W676, RLMD_BORPA;  Q7VXM6, RLMD_BORPE;  
Q1BGX9, RLMD_BURCA;  A0K7U1, RLMD_BURCH;  Q0BEW2, RLMD_BURCM;  
Q39FQ4, RLMD_BURL3;  Q62JV9, RLMD_BURMA;  Q3JRP8, RLMD_BURP1;  
Q63UT8, RLMD_BURPS;  Q2SWE9, RLMD_BURTA;  Q13Z67, RLMD_BURXL;  
B3PL62, RLMD_CELJU;  Q1QX18, RLMD_CHRSD;  Q7NWP9, RLMD_CHRVO;  
A8ANZ1, RLMD_CITK8;  Q47WQ1, RLMD_COLP3;  A7MQZ8, RLMD_CROS8;  
Q1LLI5, RLMD_CUPMC;  Q0K956, RLMD_CUPNH;  Q46ZH7, RLMD_CUPPJ;  
Q47HS4, RLMD_DECAR;  A5EXR9, RLMD_DICNV;  Q8XED8, RLMD_ECO57;  
A1AEX2, RLMD_ECOK1;  Q0TE74, RLMD_ECOL5;  Q8FEG6, RLMD_ECOL6;  
P55135, RLMD_ECOLI;  Q1R7Q7, RLMD_ECOUT;  C5B8X6, RLMD_EDWI9;  
A4WDX1, RLMD_ENT38;  B2VFZ2, RLMD_ERWT9;  E1SSZ4, RLMD_FERBD;  
Q14IC3, RLMD_FRAT1;  Q2A275, RLMD_FRATH;  A0Q5J5, RLMD_FRATN;  
Q0BKU7, RLMD_FRATO;  Q5NGX1, RLMD_FRATT;  Q7VKU9, RLMD_HAEDU;  
Q4QNK7, RLMD_HAEI8;  P44643, RLMD_HAEIN;  E1W218, RLMD_HAEP3;  
Q0I127, RLMD_HAES1;  Q2SL27, RLMD_HAHCH;  E1V4F9, RLMD_HALED;  
Q5R111, RLMD_IDILO;  B5XV15, RLMD_KLEP3;  A6TD57, RLMD_KLEP7;  
Q5X5A8, RLMD_LEGPA;  A5IBU7, RLMD_LEGPC;  Q5ZVI4, RLMD_LEGPH;  
Q5WW81, RLMD_LEGPL;  Q65W13, RLMD_MANSM;  A1U2U9, RLMD_MARHV;  
F2JTX5, RLMD_MARM1;  A6VUQ2, RLMD_MARMS;  F6CY50, RLMD_MARPP;  
Q606W5, RLMD_METCA;  Q1H069, RLMD_METFK;  E4ZBM0, RLMD_NEIL0;  
Q2Y6W3, RLMD_NITMU;  Q3JCY2, RLMD_NITOC;  Q9CJX3, RLMD_PASMU;  
Q6D178, RLMD_PECAS;  C6DDJ9, RLMD_PECCP;  P55136, RLMD_PHOAS;  
Q7N839, RLMD_PHOLL;  Q6LMS7, RLMD_PHOPR;  A1VQF1, RLMD_POLNA;  
B1XU70, RLMD_POLNS;  Q128S1, RLMD_POLSJ;  B4EUF2, RLMD_PROMH;  
Q48FH7, RLMD_PSE14;  Q02I93, RLMD_PSEAB;  Q9I525, RLMD_PSEAE;  
Q1IDL9, RLMD_PSEE4;  Q4K898, RLMD_PSEF5;  Q3IDM6, RLMD_PSEHT;  
Q3K8E9, RLMD_PSEPF;  Q88MB9, RLMD_PSEPK;  Q885Y8, RLMD_PSESM;  
Q4ZQ44, RLMD_PSEU2;  Q4FUU5, RLMD_PSYA2;  Q1QDU2, RLMD_PSYCK;  
A1SSB8, RLMD_PSYIN;  B2U9U3, RLMD_RALPJ;  Q8Y035, RLMD_RALSO;  
Q21UR3, RLMD_RHOFT;  Q9JP88, RLMD_RUBGI;  Q57KF9, RLMD_SALCH;  
Q5PEJ4, RLMD_SALPA;  Q8Z446, RLMD_SALTI;  Q8ZME1, RLMD_SALTY;  
A1S4D3, RLMD_SHEAM;  B8E8S1, RLMD_SHEB2;  A3D7B5, RLMD_SHEB5;  
A6WR37, RLMD_SHEB8;  A9KYI1, RLMD_SHEB9;  Q12PZ8, RLMD_SHEDO;  
Q086B4, RLMD_SHEFN;  B0TK00, RLMD_SHEHH;  Q8EBQ3, RLMD_SHEON;  
A8H1S1, RLMD_SHEPA;  A4Y952, RLMD_SHEPC;  B8CJP2, RLMD_SHEPW;  
A0KU76, RLMD_SHESA;  A8FSS4, RLMD_SHESH;  Q0HL77, RLMD_SHESM;  
Q0HXI0, RLMD_SHESR;  A1RHE4, RLMD_SHESW;  B1KPU0, RLMD_SHEWM;  
Q31XK5, RLMD_SHIBS;  Q32CD0, RLMD_SHIDS;  Q0T1Q1, RLMD_SHIF8;  
Q83QD5, RLMD_SHIFL;  Q3YY71, RLMD_SHISS;  B4SRK6, RLMD_STRM5;  
B2FPX2, RLMD_STRMK;  Q31DJ1, RLMD_THICR;  Q3SK67, RLMD_THIDA;  
C4LBR5, RLMD_TOLAT;  A1WME3, RLMD_VEREI;  A5CXB2, RLMD_VESOH;  
A5F5I8, RLMD_VIBC3;  A7MTS9, RLMD_VIBCB;  Q9KPC1, RLMD_VIBCH;  
C3LQZ5, RLMD_VIBCM;  Q5E320, RLMD_VIBF1;  B5FAG4, RLMD_VIBFM;  
Q87LP5, RLMD_VIBPA;  B7VK72, RLMD_VIBTL;  Q8DC67, RLMD_VIBVU;  
Q7MHP7, RLMD_VIBVY;  Q8PMU6, RLMD_XANAC;  Q3BVV1, RLMD_XANC5;  
Q4USG1, RLMD_XANC8;  Q8PB48, RLMD_XANCP;  Q2P4L7, RLMD_XANOM;  
Q5H1Q8, RLMD_XANOR;  Q9PAY7, RLMD_XYLFA;  Q87BR3, RLMD_XYLFT;  
A1JJR0, RLMD_YERE8;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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