ENZYME entry: EC 2.1.1.197

Accepted Name
Malonyl-[acyl-carrier protein] O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] <=> S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester
Comment(s)
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
Cross-references
BRENDA2.1.1.197
EC2PDB2.1.1.197
ExplorEnz2.1.1.197
PRIAM enzyme-specific profiles2.1.1.197
KEGG Ligand Database for Enzyme Nomenclature2.1.1.197
IUBMB Enzyme Nomenclature2.1.1.197
IntEnz2.1.1.197
MEDLINEFind literature relating to 2.1.1.197
MetaCyc2.1.1.197
UniProtKB/Swiss-Prot
Q83E64, BIOC1_COXBU;  E3H9W1, BIOC1_ILYPC;  Q83CU8, BIOC2_COXBU;  
E3HCT1, BIOC2_ILYPC;  Q2KXN6, BIOCD_BORA1;  Q6FDV0, BIOC_ACIAD;  
Q0VMD3, BIOC_ALCBS;  B7GHW9, BIOC_ANOFW;  Q81MB2, BIOC_BACAN;  
A7GSD9, BIOC_BACCN;  Q818X2, BIOC_BACCR;  E1WTS2, BIOC_BACF6;  
Q64VX6, BIOC_BACFR;  Q9K623, BIOC_BACHD;  D5DIV9, BIOC_BACMD;  
E6SRF9, BIOC_BACT6;  Q8A7S9, BIOC_BACTN;  C0Z787, BIOC_BREBN;  
Q89AK7, BIOC_BUCBP;  E4TI44, BIOC_CALNY;  Q3B172, BIOC_CHLL7;  
A4SGV9, BIOC_CHLPM;  A3DBD7, BIOC_CLOTH;  Q47C02, BIOC_DECAR;  
P12999, BIOC_ECOLI;  E3G327, BIOC_ENTLS;  D8MPW4, BIOC_ERWBE;  
D2T333, BIOC_ERWP6;  O06898, BIOC_ESCVU;  D9SJ16, BIOC_GALCS;  
Q749W5, BIOC_GEOSL;  Q7VL11, BIOC_HAEDU;  P45249, BIOC_HAEIN;  
Q2SBD7, BIOC_HAHCH;  A1WVM4, BIOC_HALHL;  C4K5L7, BIOC_HAMD5;  
A4G5P1, BIOC_HERAR;  C1D5S5, BIOC_LARHH;  Q5ZT34, BIOC_LEGPH;  
A0L3L9, BIOC_MAGMM;  A6W0X8, BIOC_MARMS;  Q609U9, BIOC_METCA;  
E4QJB8, BIOC_METS6;  C6V598, BIOC_NEORI;  Q2Y9Y6, BIOC_NITMU;  
C6CWS7, BIOC_PAESJ;  Q6D3C1, BIOC_PECAS;  Q7MUB2, BIOC_PORGI;  
B4S687, BIOC_PROA2;  A6UYW3, BIOC_PSEA7;  Q8ZQQ6, BIOC_SALTY;  
P36571, BIOC_SERMA;  Q8EDK8, BIOC_SHEON;  B2IAI0, BIOC_XYLF2;  
Q7CH67, BIOC_YERPE;  B3PI89, BIOHC_CELJU;  Q21FY5, BIOHC_SACD2;  
C5BMZ8, BIOHC_TERTT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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