Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.1.1.197

Accepted Name
Malonyl-[acyl-carrier protein] O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] <=> S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester
Comment(s)
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
Cross-references
BRENDA2.1.1.197
EC2PDB2.1.1.197
ExplorEnz2.1.1.197
PRIAM enzyme-specific profiles2.1.1.197
KEGG Ligand Database for Enzyme Nomenclature2.1.1.197
IUBMB Enzyme Nomenclature2.1.1.197
IntEnz2.1.1.197
MEDLINEFind literature relating to 2.1.1.197
MetaCyc2.1.1.197
UniProtKB/Swiss-Prot
Q83E64, BIOC1_COXBU;  E3H9W1, BIOC1_ILYPC;  Q83CU8, BIOC2_COXBU;  
E3HCT1, BIOC2_ILYPC;  Q2KXN6, BIOCD_BORA1;  Q6FDV0, BIOC_ACIAD;  
Q0VMD3, BIOC_ALCBS;  B7GHW9, BIOC_ANOFW;  Q81MB2, BIOC_BACAN;  
A7GSD9, BIOC_BACCN;  Q818X2, BIOC_BACCR;  E1WTS2, BIOC_BACF6;  
Q64VX6, BIOC_BACFR;  Q9K623, BIOC_BACHD;  D5DIV9, BIOC_BACMD;  
E6SRF9, BIOC_BACT6;  Q8A7S9, BIOC_BACTN;  C0Z787, BIOC_BREBN;  
Q89AK7, BIOC_BUCBP;  E4TI44, BIOC_CALNY;  Q3B172, BIOC_CHLL7;  
A4SGV9, BIOC_CHLPM;  A3DBD7, BIOC_CLOTH;  Q47C02, BIOC_DECAR;  
P12999, BIOC_ECOLI;  E3G327, BIOC_ENTLS;  D8MPW4, BIOC_ERWBE;  
D2T333, BIOC_ERWP6;  O06898, BIOC_ESCVU;  D9SJ16, BIOC_GALCS;  
Q749W5, BIOC_GEOSL;  Q7VL11, BIOC_HAEDU;  P45249, BIOC_HAEIN;  
Q2SBD7, BIOC_HAHCH;  A1WVM4, BIOC_HALHL;  C4K5L7, BIOC_HAMD5;  
A4G5P1, BIOC_HERAR;  C1D5S5, BIOC_LARHH;  Q5ZT34, BIOC_LEGPH;  
A0L3L9, BIOC_MAGMM;  A6W0X8, BIOC_MARMS;  Q609U9, BIOC_METCA;  
E4QJB8, BIOC_METS6;  C6V598, BIOC_NEORI;  Q2Y9Y6, BIOC_NITMU;  
C6CWS7, BIOC_PAESJ;  Q6D3C1, BIOC_PECAS;  Q7MUB2, BIOC_PORGI;  
B4S687, BIOC_PROA2;  A6UYW3, BIOC_PSEA7;  Q8ZQQ6, BIOC_SALTY;  
P36571, BIOC_SERMA;  Q8EDK8, BIOC_SHEON;  B2IAI0, BIOC_XYLF2;  
Q7CH67, BIOC_YERPE;  B3PI89, BIOHC_CELJU;  Q21FY5, BIOHC_SACD2;  
C5BMZ8, BIOHC_TERTT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-