ENZYME entry: EC 2.1.1.20
| Accepted Name |
|---|
| Glycine N-methyltransferase.
|
| Alternative Name(s) |
|---|
| Glycine methyltransferase. |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + glycine <=> S-adenosyl-L-homocysteine + sarcosine |
| Comment(s) |
|---|
- Thought to play an important role in the regulation of methyl group
metabolism in the liver and pancreas by regulating the ratio between
S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
- Inhibited by 5-methyltetrahydrofolate pentaglutamate.
- Sarcosine, which has no physiological role, is converted back into
glycine by the action of EC 1.5.99.1.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.20 |
| EC2PDB | 2.1.1.20 |
| ExplorEnz | 2.1.1.20 |
| PRIAM enzyme-specific profiles | 2.1.1.20 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.20 |
| IUBMB Enzyme Nomenclature | 2.1.1.20 |
| IntEnz | 2.1.1.20 |
| MEDLINE | Find literature relating to 2.1.1.20 |
| MetaCyc | 2.1.1.20 |
| UniProtKB/Swiss-Prot |
|
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