ENZYME entry: EC 2.1.1.216

Accepted Name
tRNA (guanine(26)-N(2))-dimethyltransferase.
Alternative Name(s)
tRNA (m(2)(2)G(26))dimethyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + guanine(26) in tRNA <=> 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA
Comment(s)
  • The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
  • In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA.
  • Formerly EC 2.1.1.32.
Cross-references
BRENDA2.1.1.216
EC2PDB2.1.1.216
ExplorEnz2.1.1.216
PRIAM enzyme-specific profiles2.1.1.216
KEGG Ligand Database for Enzyme Nomenclature2.1.1.216
IUBMB Enzyme Nomenclature2.1.1.216
IntEnz2.1.1.216
MEDLINEFind literature relating to 2.1.1.216
MetaCyc2.1.1.216
UniProtKB/Swiss-Prot
Q9YDY7, TRM1_AERPE;  Q9LFU5, TRM1_ARATH;  O29443, TRM1_ARCFU;  
Q23270, TRM1_CAEEL;  Q9VK89, TRM1_DROME;  Q8SR99, TRM1_ENCCU;  
B9LSI7, TRM1_HALLT;  Q5UYV8, TRM1_HALMA;  B0R713, TRM1_HALS3;  
P57705, TRM1_HALSA;  Q18EA0, TRM1_HALWD;  Q9NXH9, TRM1_HUMAN;  
A6UUN6, TRM1_META3;  Q8TGX6, TRM1_METAC;  A7I9E9, TRM1_METB6;  
Q466T6, TRM1_METBF;  Q12Y46, TRM1_METBU;  Q2FN43, TRM1_METHJ;  
Q58356, TRM1_METJA;  Q8TYY7, TRM1_METKA;  A2SRK9, TRM1_METLZ;  
A4FZY5, TRM1_METM5;  A9A871, TRM1_METM6;  A6VIL5, TRM1_METM7;  
Q8PU28, TRM1_METMA;  P0CW64, TRM1_METMI;  A3CW75, TRM1_METMJ;  
P0CW65, TRM1_METMP;  B8GF12, TRM1_METPE;  A5UM08, TRM1_METS3;  
A4YHH9, TRM1_METS5;  Q2NI56, TRM1_METST;  O27258, TRM1_METTH;  
Q3TX08, TRM1_MOUSE;  Q3IUJ2, TRM1_NATPD;  Q9V1P3, TRM1_PYRAB;  
Q8ZWT5, TRM1_PYRAE;  A4WMB7, TRM1_PYRAR;  A3MTQ5, TRM1_PYRCJ;  
P81554, TRM1_PYRFU;  O59493, TRM1_PYRHO;  A1RV26, TRM1_PYRIL;  
B1YCV9, TRM1_PYRNV;  P20300, TRM1_PYRWO;  Q9P804, TRM1_SCHPO;  
Q4J947, TRM1_SULAC;  C3N5E1, TRM1_SULIA;  C4KH07, TRM1_SULIK;  
C3MPR5, TRM1_SULIL;  C3MYQ9, TRM1_SULIM;  C3NHQ8, TRM1_SULIN;  
C3NDZ5, TRM1_SULIY;  Q97ZH0, TRM1_SULSO;  Q971V9, TRM1_SULTO;  
P57706, TRM1_THEAC;  C5A6N2, TRM1_THEGJ;  Q5JIB3, TRM1_THEKO;  
B6YUU9, TRM1_THEON;  Q97AR2, TRM1_THEVO;  P15565, TRM1_YEAST;  
Q9SRU7, TRM2_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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