ENZYME entry: EC 2.1.1.221

Accepted Name
tRNA (guanine(9)-N(1))-methyltransferase.
Alternative Name(s)
tRNA m(1)G(9) MTase.
tRNA m(1)G(9)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + guanine(9) in tRNA <=> S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA
Comment(s)
  • The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9).
  • The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218).
  • Formerly EC 2.1.1.31.
Cross-references
BRENDA2.1.1.221
EC2PDB2.1.1.221
ExplorEnz2.1.1.221
PRIAM enzyme-specific profiles2.1.1.221
KEGG Ligand Database for Enzyme Nomenclature2.1.1.221
IUBMB Enzyme Nomenclature2.1.1.221
IntEnz2.1.1.221
MEDLINEFind literature relating to 2.1.1.221
MetaCyc2.1.1.221
UniProtKB/Swiss-Prot
Q75A17, TRM10_ASHGO;  Q4WXA1, TRM10_ASPFU;  Q59Q39, TRM10_CANAL;  
Q6FQB2, TRM10_CANGA;  P0CS11, TRM10_CRYNB;  P0CS10, TRM10_CRYNJ;  
Q6BWG3, TRM10_DEBHA;  Q5B8X0, TRM10_EMENI;  Q4I8X0, TRM10_GIBZE;  
Q6CUM6, TRM10_KLULA;  O14214, TRM10_SCHPO;  Q5JD38, TRM10_THEKO;  
Q6C1W9, TRM10_YARLI;  Q12400, TRM10_YEAST;  

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