ENZYME entry: EC 2.1.1.230

Accepted Name
23S rRNA (adenosine(1067)-2'-O)-methyltransferase.
Alternative Name(s)
23S rRNA A(1067) 2'-methyltransferase.
Nosiheptide-resistance methyltransferase.
Thiostrepton-resistance methylase.
Reaction catalysed
S-adenosyl-L-methionine + adenosine(1067) in 23S rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methyladenosine(1067) in 23S rRNA
Comment(s)
  • The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton.
  • Formerly EC 2.1.1.66.
Cross-references
BRENDA2.1.1.230
EC2PDB2.1.1.230
ExplorEnz2.1.1.230
PRIAM enzyme-specific profiles2.1.1.230
KEGG Ligand Database for Enzyme Nomenclature2.1.1.230
IUBMB Enzyme Nomenclature2.1.1.230
IntEnz2.1.1.230
MEDLINEFind literature relating to 2.1.1.230
MetaCyc2.1.1.230
UniProtKB/Swiss-Prot
P52391, NSHR_STRAS;  P18644, TSNR_STRAJ;  P52393, TSNR_STRLU;  

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