ENZYME entry: EC 2.1.1.233

Accepted Name
[Phosphatase 2A protein]-leucine-carboxy methyltransferase.
Alternative Name(s)
Leucine carboxy methyltransferase-1.
Reaction catalysed
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine <=> S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Comment(s)
  • Methylates the C-terminal leucine of phosphatase 2A.
  • A key regulator of protein phosphatase 2A.
  • The methyl ester is hydrolyzed by EC 3.1.1.89.
  • Occurs mainly in the cytoplasm, Golgi region and late endosomes.
Cross-references
BRENDA2.1.1.233
EC2PDB2.1.1.233
ExplorEnz2.1.1.233
PRIAM enzyme-specific profiles2.1.1.233
KEGG Ligand Database for Enzyme Nomenclature2.1.1.233
IUBMB Enzyme Nomenclature2.1.1.233
IntEnz2.1.1.233
MEDLINEFind literature relating to 2.1.1.233
MetaCyc2.1.1.233
UniProtKB/Swiss-Prot
Q759U5, LCMT1_ASHGO;  Q4WS57, LCMT1_ASPFU;  Q3T0H0, LCMT1_BOVIN;  
Q60YU0, LCMT1_CAEBR;  P46554, LCMT1_CAEEL;  Q5A387, LCMT1_CANAL;  
Q6FUI5, LCMT1_CANGA;  P0CO57, LCMT1_CRYNB;  P0CO56, LCMT1_CRYNJ;  
Q6BQD2, LCMT1_DEBHA;  Q5AQJ2, LCMT1_EMENI;  Q4ICG8, LCMT1_GIBZE;  
Q9UIC8, LCMT1_HUMAN;  Q6CWW0, LCMT1_KLULA;  Q7SAP7, LCMT1_NEUCR;  
Q6P4Z6, LCMT1_RAT;  O94257, LCMT1_SCHPO;  Q4P4G2, LCMT1_USTMA;  
Q6C997, LCMT1_YARLI;  Q04081, LCMT1_YEAST;  

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