ENZYME entry: EC 2.1.1.248

Accepted Name
[Methylamine--corrinoid protein] Co-methyltransferase.
Alternative Name(s)
Monomethylamine methyltransferase.
Reaction catalysed
Methylamine + a [Co(I) methylamine-specific corrinoid protein] <=> a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
Comment(s)
  • The enzyme, which catalyzes the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC 2.1.1.247.
Cross-references
BRENDA2.1.1.248
EC2PDB2.1.1.248
ExplorEnz2.1.1.248
PRIAM enzyme-specific profiles2.1.1.248
KEGG Ligand Database for Enzyme Nomenclature2.1.1.248
IUBMB Enzyme Nomenclature2.1.1.248
IntEnz2.1.1.248
MEDLINEFind literature relating to 2.1.1.248
MetaCyc2.1.1.248
UniProtKB/Swiss-Prot
P58865, MTMB1_METAC;  O30642, MTMB1_METBA;  Q46E72, MTMB1_METBF;  
P58866, MTMB2_METAC;  Q9P9L4, MTMB2_METBA;  P0C0W3, MTMB2_METBF;  
P0C0W4, MTMB3_METBF;  P58969, MTMB_METMA;  

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