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ENZYME entry: EC

Accepted Name
[Trimethylamine--corrinoid protein] Co-methyltransferase.
Alternative Name(s)
Trimethylamine methyltransferase.
Reaction catalysed
Trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] <=> a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
  • The enzyme, which catalyzes the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC
PRIAM enzyme-specific profiles2.1.1.250
KEGG Ligand Database for Enzyme Nomenclature2.1.1.250
IUBMB Enzyme Nomenclature2.1.1.250
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