ENZYME entry: EC 2.1.1.250

Accepted Name
[Trimethylamine--corrinoid protein] Co-methyltransferase.
Alternative Name(s)
Trimethylamine methyltransferase.
Reaction catalysed
Trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] <=> a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
Comment(s)
  • The enzyme, which catalyzes the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC 2.1.1.247.
Cross-references
BRENDA2.1.1.250
EC2PDB2.1.1.250
ExplorEnz2.1.1.250
PRIAM enzyme-specific profiles2.1.1.250
KEGG Ligand Database for Enzyme Nomenclature2.1.1.250
IUBMB Enzyme Nomenclature2.1.1.250
IntEnz2.1.1.250
MEDLINEFind literature relating to 2.1.1.250
MetaCyc2.1.1.250
UniProtKB/Swiss-Prot
Q8TTA9, MTTB1_METAC;  P58973, MTTB1_METMA;  Q8TS73, MTTB2_METAC;  
P58974, MTTB2_METMA;  Q18TV3, MTTB_DESHD;  Q24MI3, MTTB_DESHY;  
O93658, MTTB_METBA;  P0C0W7, MTTB_METBF;  Q12TR2, MTTB_METBU;  
Q9P995, MTTB_METTE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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