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ENZYME

ENZYME entry: EC 2.1.1.389

Accepted Name
[methyl-Co(III) quaternary-amine-specific corrinoid protein]- -tetrahydrofolate methyltransferase
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)
Comment(s)
  • The enzyme, characterized from the acetogenic gut bacterium Eubacterium limosum, participates in a pathway for the degradation of some quaternary amine compounds (L-proline betaine and L-carnitine).
  • The enzyme catalyzes the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (bacterial MtqC) to tetrahydrofolate.
  • The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood--Ljungdahl pathway.
Cross-references
BRENDA2.1.1.389
EC2PDB2.1.1.389
ExplorEnz2.1.1.389
PRIAM enzyme-specific profiles2.1.1.389
KEGG Ligand Database for Enzyme Nomenclature2.1.1.389
IUBMB Enzyme Nomenclature2.1.1.389
IntEnz2.1.1.389
MEDLINEFind literature relating to 2.1.1.389
MetaCyc2.1.1.389
Rhea expert-curated reactions2.1.1.389

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-