ENZYME entry: EC 2.1.1.43

Accepted Name
Histone-lysine N-methyltransferase.
Alternative Name(s)
Protein methylase 3.
Protein methylase III.
Protein methyltransferase II.
Protein-lysine N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + L-lysine-[histone] <=> S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Cross-references
BRENDA2.1.1.43
EC2PDB2.1.1.43
ExplorEnz2.1.1.43
PRIAM enzyme-specific profiles2.1.1.43
KEGG Ligand Database for Enzyme Nomenclature2.1.1.43
IUBMB Enzyme Nomenclature2.1.1.43
IntEnz2.1.1.43
MEDLINEFind literature relating to 2.1.1.43
MetaCyc2.1.1.43
UniProtKB/Swiss-Prot
Q9NR48, ASH1L_HUMAN;  Q99MY8, ASH1L_MOUSE;  Q9VW15, ASH1_DROME;  
Q84WW6, ASHH1_ARATH;  Q2LAE1, ASHH2_ARATH;  Q945S8, ASHH3_ARATH;  
Q9M1X9, ASHH4_ARATH;  Q7XJS0, ASHR1_ARATH;  Q9ZUM9, ASHR2_ARATH;  
Q949T8, ASHR3_ARATH;  Q9C5X4, ATX1_ARATH;  P0CB22, ATX2_ARATH;  
Q9M364, ATX3_ARATH;  Q9SUE7, ATX4_ARATH;  Q8GZ42, ATX5_ARATH;  
Q5PP37, ATXR2_ARATH;  O23372, ATXR3_ARATH;  Q9FG08, ATXR4_ARATH;  
Q8VZJ1, ATXR5_ARATH;  Q9FNE9, ATXR6_ARATH;  Q9VYD1, C1716_DROME;  
P93831, CLF_ARATH;  O60016, CLR4_SCHPO;  Q8X225, DIM5_NEUCR;  
Q55AX2, DOT1L_DICDI;  Q8INR6, DOT1L_DROME;  Q8TEK3, DOT1L_HUMAN;  
Q756E1, DOT1_ASHGO;  Q4WVH4, DOT1_ASPFU;  Q2U696, DOT1_ASPOR;  
Q5A309, DOT1_CANAL;  Q6FNM5, DOT1_CANGA;  Q2H9L1, DOT1_CHAGB;  
Q1DKD8, DOT1_COCIM;  P0CN15, DOT1_CRYNB;  P0CN14, DOT1_CRYNJ;  
Q6BTC8, DOT1_DEBHA;  Q5BH89, DOT1_EMENI;  Q4IJP1, DOT1_GIBZE;  
Q6CWV1, DOT1_KLULA;  Q7SB74, DOT1_NEUCR;  Q4P2W8, DOT1_USTMA;  
Q6C4Y5, DOT1_YARLI;  Q04089, DOT1_YEAST;  Q9H9B1, EHMT1_HUMAN;  
Q5DW34, EHMT1_MOUSE;  Q96KQ7, EHMT2_HUMAN;  Q9Z148, EHMT2_MOUSE;  
Q8S4P6, EZ1_MAIZE;  Q8S4P5, EZ2_MAIZE;  Q8S4P4, EZ3_MAIZE;  
Q9ZSM8, EZA1_ARATH;  A7E2Z2, EZH1_BOVIN;  Q92800, EZH1_HUMAN;  
P70351, EZH1_MOUSE;  Q5RDS6, EZH1_PONAB;  Q98SM3, EZH2A_XENLA;  
Q4V863, EZH2B_XENLA;  Q08BS4, EZH2_DANRE;  Q15910, EZH2_HUMAN;  
Q4R381, EZH2_MACFA;  Q61188, EZH2_MOUSE;  Q28D84, EZH2_XENTR;  
P42124, EZ_DROME;  Q03164, KMT2A_HUMAN;  P55200, KMT2A_MOUSE;  
Q9UMN6, KMT2B_HUMAN;  O08550, KMT2B_MOUSE;  Q8NEZ4, KMT2C_HUMAN;  
Q8BRH4, KMT2C_MOUSE;  O14686, KMT2D_HUMAN;  Q6PDK2, KMT2D_MOUSE;  
Q8IZD2, KMT2E_HUMAN;  Q3UG20, KMT2E_MOUSE;  O44757, LIN59_CAEEL;  
O65312, MEDEA_ARATH;  O17514, MES2_CAEEL;  Q9NH52, MES4_CAEEL;  
Q8MT36, MES4_DROME;  P34544, MET2_CAEEL;  Q96L73, NSD1_HUMAN;  
O88491, NSD1_MOUSE;  O96028, NSD2_HUMAN;  Q8BVE8, NSD2_MOUSE;  
Q9BZ95, NSD3_HUMAN;  Q6P2L6, NSD3_MOUSE;  Q13029, PRDM2_HUMAN;  
Q63755, PRDM2_RAT;  A6QPM3, PRDM6_BOVIN;  Q9NQX0, PRDM6_HUMAN;  
Q3UZD5, PRDM6_MOUSE;  Q9NQW5, PRDM7_HUMAN;  Q6P2A1, PRDM9_DANRE;  
Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT;  
Q6GP17, S421A_XENLA;  Q5RJX8, S421B_XENLA;  Q1LY77, SE1BA_DANRE;  
O15047, SET1A_HUMAN;  Q5F3P8, SET1B_CHICK;  Q9UPS6, SET1B_HUMAN;  
Q8CFT2, SET1B_MOUSE;  Q66J90, SET1B_XENLA;  Q08D57, SET1B_XENTR;  
Q75D88, SET1_ASHGO;  Q4WNH8, SET1_ASPFU;  Q2UMH3, SET1_ASPOR;  
Q22795, SET1_CAEEL;  Q5ABG1, SET1_CANAL;  Q6FKB1, SET1_CANGA;  
Q2GWF3, SET1_CHAGB;  Q1DR06, SET1_COCIM;  P0CO27, SET1_CRYNB;  
P0CO26, SET1_CRYNJ;  Q6BKL7, SET1_DEBHA;  Q54HS3, SET1_DICDI;  
Q5B0Y5, SET1_EMENI;  Q4I5R3, SET1_GIBZE;  Q6CIT4, SET1_KLULA;  
Q8X0S9, SET1_NEUCR;  C6KTD2, SET1_PLAF7;  Q9Y7R4, SET1_SCHPO;  
Q4PB36, SET1_USTMA;  Q6CEK8, SET1_YARLI;  P38827, SET1_YEAST;  
A8XI75, SET23_CAEBR;  Q95Y12, SET23_CAEEL;  Q757Y8, SET2_ASHGO;  
Q4WTT2, SET2_ASPFU;  Q2UTN6, SET2_ASPOR;  Q18221, SET2_CAEEL;  
Q59XV0, SET2_CANAL;  Q6FX50, SET2_CANGA;  Q2H988, SET2_CHAGB;  
Q1DU03, SET2_COCIM;  P0CO29, SET2_CRYNB;  P0CO28, SET2_CRYNJ;  
Q6BM04, SET2_DEBHA;  Q5ASA5, SET2_EMENI;  Q4IB50, SET2_GIBZE;  
Q6CXP5, SET2_KLULA;  Q7RZU4, SET2_NEUCR;  O14026, SET2_SCHPO;  
Q4PBL3, SET2_USTMA;  Q6C5G5, SET2_YARLI;  P46995, SET2_YEAST;  
O74467, SET5_SCHPO;  Q9Y7Q6, SET7_SCHPO;  Q071E0, SET8A_DANRE;  
Q08AY6, SET8A_XENLA;  Q498E6, SET8B_XENLA;  Q4X1W8, SET9_ASPFU;  
Q2TZH4, SET9_ASPOR;  Q0C9E6, SET9_ASPTN;  Q2H8D5, SET9_CHAGB;  
Q1E9C0, SET9_COCIM;  Q5AZY3, SET9_EMENI;  Q4I8C9, SET9_GIBZE;  
Q7SBJ9, SET9_NEUCR;  Q0U3A4, SET9_PHANO;  Q9USK2, SET9_SCHPO;  
Q6C519, SET9_YARLI;  Q32KD2, SETB1_DROME;  Q28Z18, SETB1_DROPS;  
Q15047, SETB1_HUMAN;  O88974, SETB1_MOUSE;  Q6INA9, SETB1_XENLA;  
Q06ZW3, SETB2_DANRE;  Q96T68, SETB2_HUMAN;  Q8C267, SETB2_MOUSE;  
Q6YI93, SETB2_XENLA;  A4IGY9, SETB2_XENTR;  Q9BYW2, SETD2_HUMAN;  
E9Q5F9, SETD2_MOUSE;  B0VX69, SETD3_CALJA;  B1MTJ4, SETD3_CALMO;  
E2RBS6, SETD3_CANFA;  Q5ZML9, SETD3_CHICK;  Q7SXS7, SETD3_DANRE;  
C1FXW2, SETD3_DASNO;  Q86TU7, SETD3_HUMAN;  Q91WC0, SETD3_MOUSE;  
B5FW36, SETD3_OTOGA;  A9X1D0, SETD3_PAPAN;  B2KI88, SETD3_RHIFE;  
B7ZUF3, SETD3_XENTR;  Q6DHG0, SETD7_DANRE;  Q7Z0G7, SETD7_HALRO;  
Q8WTS6, SETD7_HUMAN;  Q8VHL1, SETD7_MOUSE;  Q4QQN5, SETD7_XENTR;  
Q2YDJ8, SETD8_BOVIN;  Q9VFK6, SETD8_DROME;  Q297V5, SETD8_DROPS;  
Q9NQR1, SETD8_HUMAN;  Q2YDW7, SETD8_MOUSE;  Q0V9E9, SETD8_XENTR;  
Q0VD24, SETMR_BOVIN;  Q53H47, SETMR_HUMAN;  Q80UJ9, SETMR_MOUSE;  
Q5I0M0, SETMR_RAT;  Q8IE95, SETVS_PLAF7;  Q5BJI7, SMY2A_DANRE;  
Q7ZXV5, SMY2A_XENLA;  Q5RGL7, SMY2B_DANRE;  Q6GN68, SMY2B_XENLA;  
Q8NB12, SMYD1_HUMAN;  P97443, SMYD1_MOUSE;  Q0P585, SMYD2_BOVIN;  
E1C5V0, SMYD2_CHICK;  Q9NRG4, SMYD2_HUMAN;  Q8R5A0, SMYD2_MOUSE;  
C3RZA1, SMYD2_PIG;  Q7M6Z3, SMYD2_RAT;  Q9H7B4, SMYD3_HUMAN;  
Q9CWR2, SMYD3_MOUSE;  Q1L8U8, STB1A_DANRE;  Q08BR4, STB1B_DANRE;  
P45975, SUV39_DROME;  Q294B9, SUV39_DROPS;  A8WTV9, SUV42_CAEBR;  
Q09265, SUV42_CAEEL;  Q9W5E0, SUV42_DROME;  Q2NL30, SUV91_BOVIN;  
O43463, SUV91_HUMAN;  O54864, SUV91_MOUSE;  Q5RB81, SUV91_PONAB;  
Q6NRE8, SUV91_XENLA;  Q32PH7, SUV92_BOVIN;  Q5F3W5, SUV92_CHICK;  
Q9H5I1, SUV92_HUMAN;  Q4R3E0, SUV92_MACFA;  Q9EQQ0, SUV92_MOUSE;  
Q28CQ7, SUV92_XENTR;  Q9FF80, SUVH1_ARATH;  Q93YF5, SUVH1_TOBAC;  
O22781, SUVH2_ARATH;  Q9C5P4, SUVH3_ARATH;  Q5QD03, SUVH3_CHLRE;  
Q8GZB6, SUVH4_ARATH;  O82175, SUVH5_ARATH;  Q8VZ17, SUVH6_ARATH;  
Q9C5P1, SUVH7_ARATH;  Q9C5P0, SUVH8_ARATH;  Q9T0G7, SUVH9_ARATH;  
Q3EC60, SUVHA_ARATH;  Q946J2, SUVR1_ARATH;  Q9FNC7, SUVR2_ARATH;  
Q9SRV2, SUVR3_ARATH;  Q8W595, SUVR4_ARATH;  O64827, SUVR5_ARATH;  
Q29RP8, SV421_BOVIN;  Q5U3H2, SV421_DANRE;  Q4FZB7, SV421_HUMAN;  
Q3U8K7, SV421_MOUSE;  P0C2N5, SV421_RAT;  Q86Y97, SV422_HUMAN;  
Q6Q783, SV422_MOUSE;  P0C2N6, SV422_RAT;  A0JMZ4, SV422_XENLA;  
Q6DGD3, SV91A_DANRE;  Q8IRW8, TRR_DROME;  P20659, TRX_DROME;  
Q24742, TRX_DROVI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-