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ENZYME entry: EC 2.1.1.63

Accepted Name
Methylated-DNA--[protein]-cysteine S-methyltransferase.
Alternative Name(s)
6-O-methylguanine-DNA methyltransferase.
O-6-methylguanine-DNA-alkyltransferase.
Reaction catalysed
  • DNA (containing 6-O-methylguanine) + protein L-cysteine <=> DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
  • DNA (containing 4-O-methylthymine) + protein L-cysteine <=> DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Comment(s)
  • This protein is involved in the repair of methylated DNA.
  • Unlike EC 3.2.2.20 and EC 3.2.2.21, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide.
  • Since the methyl transfer is irreversible, the enzyme can only catalyze a single turnover.
Cross-references
PROSITEPDOC00320
BRENDA2.1.1.63
EC2PDB2.1.1.63
ExplorEnz2.1.1.63
PRIAM enzyme-specific profiles2.1.1.63
KEGG Ligand Database for Enzyme Nomenclature2.1.1.63
IUBMB Enzyme Nomenclature2.1.1.63
IntEnz2.1.1.63
MEDLINEFind literature relating to 2.1.1.63
MetaCyc2.1.1.63
UniProtKB/Swiss-Prot
P19220, ADAB_BACSU;  P06134, ADA_ECOLI;  P26189, ADA_SALTY;  
P29177, MGMT_BOVIN;  Q5A0Y8, MGMT_CANAL;  Q6FNR0, MGMT_CANGA;  
Q6TDU1, MGMT_CANLF;  P26186, MGMT_CRIGR;  Q6BVY4, MGMT_DEBHA;  
P16455, MGMT_HUMAN;  Q6CPW2, MGMT_KLULA;  A5E7M8, MGMT_LODEL;  
Q5UNU9, MGMT_MIMIV;  P26187, MGMT_MOUSE;  A3LZM4, MGMT_PICST;  
P24528, MGMT_RAT;  A6ZXD3, MGMT_YEAS7;  P26188, MGMT_YEAST;  
O27970, OGT_ARCFU;  P11742, OGT_BACSU;  P0AFH0, OGT_ECOLI;  
P44687, OGT_HAEIN;  Q8TI34, OGT_METAC;  Q46EW4, OGT_METBF;  
Q58924, OGT_METJA;  Q8TZ11, OGT_METKA;  Q8PY44, OGT_METMA;  
A4YH39, OGT_METS5;  O26715, OGT_METTH;  C9RE37, OGT_METVM;  
P0A697, OGT_MYCBO;  P52982, OGT_MYCLE;  Q9ZET8, OGT_MYCPA;  
P9WJW4, OGT_MYCTO;  P9WJW5, OGT_MYCTU;  Q9V1N7, OGT_PYRAB;  
O93728, OGT_PYRAE;  Q8TZV2, OGT_PYRFU;  O59499, OGT_PYRHO;  
F4HK38, OGT_PYRSN;  P0A2U1, OGT_SALTI;  P0A2U0, OGT_SALTY;  
P0AFH1, OGT_SHIFL;  Q4J9C6, OGT_SULAC;  C3N1B4, OGT_SULIA;  
C4KKV8, OGT_SULIK;  C3MKT6, OGT_SULIL;  C3MUC6, OGT_SULIM;  
C3NMY2, OGT_SULIN;  C3N9B4, OGT_SULIY;  Q97VW7, OGT_SULSO;  
Q973C7, OGT_SULTO;  F0LIT8, OGT_THEBM;  C5A3L5, OGT_THEGJ;  
O74023, OGT_THEKO;  C6A382, OGT_THESM;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-