ENZYME entry: EC 2.1.1.77

Accepted Name
Protein-L-isoaspartate(D-aspartate) O-methyltransferase.
Alternative Name(s)
L-isoaspartyl protein carboxyl methyltransferase.
Protein beta-aspartate O-methyltransferase.
Protein D-aspartate methyltransferase.
Protein L-isoaspartyl methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + protein L-isoaspartate <=> S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
Comment(s)
  • D-aspartate (but not L-aspartate) residues in proteins can also act as acceptors.
  • Formerly EC 2.1.1.24.
Cross-references
PROSITEPDOC00985
BRENDA2.1.1.77
EC2PDB2.1.1.77
ExplorEnz2.1.1.77
PRIAM enzyme-specific profiles2.1.1.77
KEGG Ligand Database for Enzyme Nomenclature2.1.1.77
IUBMB Enzyme Nomenclature2.1.1.77
IntEnz2.1.1.77
MEDLINEFind literature relating to 2.1.1.77
MetaCyc2.1.1.77
UniProtKB/Swiss-Prot
A7HC32, PIMT1_ANADF;  O30199, PIMT1_ARCFU;  Q0KB67, PIMT1_CUPNH;  
A5GEF7, PIMT1_GEOUR;  A1TZ54, PIMT1_MARAV;  Q8TT93, PIMT1_METAC;  
Q2YCR1, PIMT1_NITMU;  Q3JCZ3, PIMT1_NITOC;  A1ASL8, PIMT1_PELPD;  
Q12A85, PIMT1_POLSJ;  Q2J302, PIMT1_RHOP2;  A8FST4, PIMT1_SHESH;  
A0LL58, PIMT1_SYNFM;  A7HHV3, PIMT2_ANADF;  O27962, PIMT2_ARCFU;  
Q0K951, PIMT2_CUPNH;  A5G4S7, PIMT2_GEOUR;  A1U4P7, PIMT2_MARAV;  
Q8TT94, PIMT2_METAC;  Q2YBR7, PIMT2_NITMU;  Q3JAW6, PIMT2_NITOC;  
A1ASW6, PIMT2_PELPD;  Q123X2, PIMT2_POLSJ;  Q2IWH1, PIMT2_RHOP2;  
A8FX24, PIMT2_SHESH;  A0LM89, PIMT2_SYNFM;  A5G6S0, PIMT3_GEOUR;  
A0KGH9, PIMT_AERHH;  Q9YDA1, PIMT_AERPE;  A4SRB5, PIMT_AERS4;  
Q0VQD1, PIMT_ALCBS;  B6EKL2, PIMT_ALISL;  Q0A7L5, PIMT_ALKEH;  
B4RZG8, PIMT_ALTMD;  B8J9E3, PIMT_ANAD2;  Q2IIL9, PIMT_ANADE;  
Q42539, PIMT_ARATH;  Q5P833, PIMT_AROAE;  A8I4G3, PIMT_AZOC5;  
A1K4F0, PIMT_AZOSB;  Q2L008, PIMT_BORA1;  Q7WI37, PIMT_BORBR;  
Q7W671, PIMT_BORPA;  A9IP04, PIMT_BORPD;  P15246, PIMT_BOVIN;  
A5EJV5, PIMT_BRASB;  A4YV66, PIMT_BRASO;  B1YRE4, PIMT_BURA4;  
Q1BGY4, PIMT_BURCA;  B1JTA2, PIMT_BURCC;  A0K7U6, PIMT_BURCH;  
Q0BEV7, PIMT_BURCM;  A3MK86, PIMT_BURM7;  A2S291, PIMT_BURM9;  
Q62JV3, PIMT_BURMA;  A1V4L2, PIMT_BURMS;  A3NVY1, PIMT_BURP0;  
Q3JRP1, PIMT_BURP1;  A3NA64, PIMT_BURP6;  B2JG67, PIMT_BURP8;  
Q63UU3, PIMT_BURPS;  Q39FP9, PIMT_BURS3;  Q2SWF4, PIMT_BURTA;  
A4JEQ0, PIMT_BURVG;  Q27873, PIMT_CAEEL;  B8GX51, PIMT_CAUCN;  
Q9A6T6, PIMT_CAUCR;  B0T1Q1, PIMT_CAUSK;  B3PJA8, PIMT_CELJU;  
Q5F3N1, PIMT_CHICK;  B3EEX3, PIMT_CHLL2;  B3QQM1, PIMT_CHLP8;  
B3ELJ9, PIMT_CHLPB;  A1BDC1, PIMT_CHLPD;  Q8KFW8, PIMT_CHLTE;  
Q1QU77, PIMT_CHRSD;  Q7NRV0, PIMT_CHRVO;  A8ANV7, PIMT_CITK8;  
Q487E5, PIMT_COLP3;  A7MJ61, PIMT_CROS8;  Q46ZH2, PIMT_CUPPJ;  
Q11TS0, PIMT_CYTH3;  Q92047, PIMT_DANRE;  Q47D25, PIMT_DECAR;  
C6BTT9, PIMT_DESAD;  B8J017, PIMT_DESDA;  Q30ZM2, PIMT_DESDG;  
A8ZXR8, PIMT_DESOH;  Q6ARM1, PIMT_DESPS;  Q72AZ1, PIMT_DESVH;  
B8DJP7, PIMT_DESVM;  A1VD15, PIMT_DESVV;  Q9GPS6, PIMT_DICDI;  
B5YF00, PIMT_DICT6;  B8E0T1, PIMT_DICTD;  A8LQK6, PIMT_DINSH;  
Q27869, PIMT_DROME;  A7ZQI7, PIMT_ECO24;  B7UHG2, PIMT_ECO27;  
B7MKL7, PIMT_ECO45;  B7LEG1, PIMT_ECO55;  P0A7A6, PIMT_ECO57;  
B5Z3A5, PIMT_ECO5E;  B7NT87, PIMT_ECO7I;  B7MZ44, PIMT_ECO81;  
B7LXF5, PIMT_ECO8A;  C4ZZP7, PIMT_ECOBW;  B1XCR9, PIMT_ECODH;  
A8A3M2, PIMT_ECOHS;  A1AET7, PIMT_ECOK1;  Q8FEJ8, PIMT_ECOL6;  
B1IUT6, PIMT_ECOLC;  P0A7A5, PIMT_ECOLI;  B7N6X3, PIMT_ECOLU;  
B6I6D3, PIMT_ECOSE;  B1LQ63, PIMT_ECOSM;  Q1R7U8, PIMT_ECOUT;  
A4WDU8, PIMT_ENT38;  B2VG25, PIMT_ERWT9;  B7LWJ2, PIMT_ESCF3;  
A7HL14, PIMT_FERNB;  A5FEA5, PIMT_FLAJ1;  A6H0V1, PIMT_FLAPJ;  
B3E6I4, PIMT_GEOLS;  Q39VS0, PIMT_GEOMG;  Q74CZ5, PIMT_GEOSL;  
Q7NJY2, PIMT_GLOVI;  A0LZ51, PIMT_GRAFK;  Q2SKW3, PIMT_HAHCH;  
A1WWY5, PIMT_HALHL;  B6JMT1, PIMT_HELP2;  B5Z887, PIMT_HELPG;  
Q9ZKC2, PIMT_HELPJ;  P56133, PIMT_HELPY;  A9AUP1, PIMT_HERA2;  
A4G4J3, PIMT_HERAR;  P22061, PIMT_HUMAN;  A2BKH8, PIMT_HYPBU;  
Q5QUB2, PIMT_IDILO;  A8AAV7, PIMT_IGNH4;  A6SZX9, PIMT_JANMA;  
Q28TH8, PIMT_JANSC;  B5XV38, PIMT_KLEP3;  A6TD35, PIMT_KLEP7;  
B1L6T9, PIMT_KORCO;  Q1INS6, PIMT_KORVE;  Q1MRE5, PIMT_LAWIP;  
B1Y0T0, PIMT_LEPCP;  Q4R5H0, PIMT_MACFA;  Q2W4A2, PIMT_MAGSA;  
A0L4K5, PIMT_MAGSM;  Q0ANE2, PIMT_MARMM;  A6UWM1, PIMT_META3;  
A7I4W9, PIMT_METB6;  Q12UV0, PIMT_METBU;  A9VY77, PIMT_METEP;  
Q1H095, PIMT_METFK;  Q2FRW3, PIMT_METHJ;  Q57636, PIMT_METJA;  
Q8TYL4, PIMT_METKA;  A4G087, PIMT_METM5;  A9A8I9, PIMT_METM6;  
A6VI91, PIMT_METM7;  Q8PW90, PIMT_METMA;  A3CXP8, PIMT_METMJ;  
Q6M116, PIMT_METMP;  B1ZJW1, PIMT_METPB;  A2SF76, PIMT_METPP;  
O26915, PIMT_METTH;  A0B9U1, PIMT_METTP;  A6UR90, PIMT_METVS;  
P23506, PIMT_MOUSE;  Q1D6W9, PIMT_MYXXD;  B2A578, PIMT_NATTJ;  
Q0ADP2, PIMT_NITEC;  Q82VW0, PIMT_NITEU;  Q3SRQ7, PIMT_NITWN;  
A6X6Y1, PIMT_OCHA4;  B6JFP0, PIMT_OLICO;  B1ZPF0, PIMT_OPITP;  
A1B5M0, PIMT_PARDP;  A7HXK6, PIMT_PARL1;  Q6MCW9, PIMT_PARUW;  
Q6D1B6, PIMT_PECAS;  C6DDF9, PIMT_PECCP;  Q3A4N4, PIMT_PELCD;  
Q3B1L6, PIMT_PELLD;  B4SFU3, PIMT_PELPB;  A5CYQ6, PIMT_PELTS;  
A9BH07, PIMT_PETMO;  Q7N8K3, PIMT_PHOLL;  Q6LMT7, PIMT_PHOPR;  
P80895, PIMT_PIG;  Q5RA89, PIMT_PONAB;  B4F223, PIMT_PROMH;  
A4SGH4, PIMT_PROVI;  Q48F88, PIMT_PSE14;  Q15P27, PIMT_PSEA6;  
A6V1G4, PIMT_PSEA7;  B7V8C3, PIMT_PSEA8;  Q02R96, PIMT_PSEAB;  
P45683, PIMT_PSEAE;  Q1I655, PIMT_PSEE4;  Q4KHE7, PIMT_PSEF5;  
C3K706, PIMT_PSEFS;  Q3IDD2, PIMT_PSEHT;  A4XWR1, PIMT_PSEMY;  
A5W820, PIMT_PSEP1;  Q3KH83, PIMT_PSEPF;  B0KSC8, PIMT_PSEPG;  
Q88MF0, PIMT_PSEPK;  B1JB29, PIMT_PSEPW;  Q886L4, PIMT_PSESM;  
Q4ZWP9, PIMT_PSEU2;  A4VJV3, PIMT_PSEU5;  Q9UXX0, PIMT_PYRAB;  
Q8ZYN0, PIMT_PYRAE;  A4WNC5, PIMT_PYRAR;  A3MY16, PIMT_PYRCJ;  
Q8TZR3, PIMT_PYRFU;  O59534, PIMT_PYRHO;  A1RSC6, PIMT_PYRIL;  
B1YC47, PIMT_PYRNV;  Q8Y039, PIMT_RALSO;  P22062, PIMT_RAT;  
O08249, PIMT_RHIME;  B6ISM3, PIMT_RHOCS;  Q07N42, PIMT_RHOP5;  
Q6NCU3, PIMT_RHOPA;  Q214W4, PIMT_RHOPB;  Q136H9, PIMT_RHOPS;  
Q2RTH7, PIMT_RHORT;  A3PIZ8, PIMT_RHOS1;  Q3J3D1, PIMT_RHOS4;  
A4WU05, PIMT_RHOS5;  B9KQZ1, PIMT_RHOSK;  A7NI01, PIMT_ROSCS;  
Q163U2, PIMT_ROSDO;  A5UZW2, PIMT_ROSS1;  Q5LQ09, PIMT_RUEPO;  
Q1GFP1, PIMT_RUEST;  Q21LB7, PIMT_SACD2;  B5F407, PIMT_SALA4;  
A9MF32, PIMT_SALAR;  Q57KJ8, PIMT_SALCH;  B5FTS1, PIMT_SALDC;  
B5QW14, PIMT_SALEP;  B5RDP9, PIMT_SALG2;  B4TFW3, PIMT_SALHS;  
B4T453, PIMT_SALNS;  Q5PEE9, PIMT_SALPA;  A9N1H6, PIMT_SALPB;  
C0PXA3, PIMT_SALPC;  B5BEY0, PIMT_SALPK;  Q2S176, PIMT_SALRD;  
B4TTV7, PIMT_SALSV;  Q8Z474, PIMT_SALTI;  Q8ZMF9, PIMT_SALTY;  
Q9URZ1, PIMT_SCHPO;  A8G9Z6, PIMT_SERP5;  A1S4E3, PIMT_SHEAM;  
B8E8T7, PIMT_SHEB2;  A3D789, PIMT_SHEB5;  A6WR22, PIMT_SHEB8;  
A9KYG4, PIMT_SHEB9;  Q12PY8, PIMT_SHEDO;  Q086A4, PIMT_SHEFN;  
B0TK10, PIMT_SHEHH;  A3QC83, PIMT_SHELP;  Q8EBR6, PIMT_SHEON;  
A8H1T1, PIMT_SHEPA;  A4Y937, PIMT_SHEPC;  B8CJQ2, PIMT_SHEPW;  
A0KU88, PIMT_SHESA;  Q0HL66, PIMT_SHESM;  Q0HXG4, PIMT_SHESR;  
A1RHF9, PIMT_SHESW;  B1KPT0, PIMT_SHEWM;  B2TZI8, PIMT_SHIB3;  
Q31XA5, PIMT_SHIBS;  Q32CI7, PIMT_SHIDS;  Q0T1H4, PIMT_SHIF8;  
Q83JY3, PIMT_SHIFL;  Q3YYB9, PIMT_SHISS;  Q2NVM1, PIMT_SODGM;  
A3DMG3, PIMT_STAMF;  B4SR93, PIMT_STRM5;  B2FK95, PIMT_STRMK;  
Q2LUT4, PIMT_SYNAS;  Q2JJN4, PIMT_SYNJB;  B1XQE1, PIMT_SYNP2;  
A6LNM3, PIMT_THEM4;  Q56308, PIMT_THEMA;  B6YX51, PIMT_THEON;  
C6A3F2, PIMT_THESM;  Q3SKJ2, PIMT_THIDA;  Q0W2W0, PIMT_UNCMA;  
A5F9C1, PIMT_VIBC3;  A7MTT6, PIMT_VIBCB;  Q9KUI8, PIMT_VIBCH;  
C3LS22, PIMT_VIBCM;  Q5E332, PIMT_VIBF1;  B5FAF3, PIMT_VIBFM;  
Q87LQ6, PIMT_VIBPA;  B7VK62, PIMT_VIBSL;  Q8DC56, PIMT_VIBVU;  
Q7MHQ8, PIMT_VIBVY;  Q43209, PIMT_WHEAT;  Q8PLR3, PIMT_XANAC;  
Q3BUS3, PIMT_XANC5;  Q4UTP9, PIMT_XANC8;  B0RTZ8, PIMT_XANCB;  
Q8P9Y6, PIMT_XANCP;  Q2P1L5, PIMT_XANOM;  B2SUB3, PIMT_XANOP;  
Q5GYL2, PIMT_XANOR;  A7INP1, PIMT_XANP2;  B2I8X8, PIMT_XYLF2;  
Q9PF21, PIMT_XYLFA;  B0U4U6, PIMT_XYLFM;  Q87AK5, PIMT_XYLFT;  
A1JJT8, PIMT_YERE8;  A7FLX4, PIMT_YERP3;  Q1C474, PIMT_YERPA;  
B2K581, PIMT_YERPB;  Q8ZBQ0, PIMT_YERPE;  A9R115, PIMT_YERPG;  
Q1CLR2, PIMT_YERPN;  A4TQ01, PIMT_YERPP;  Q66EB9, PIMT_YERPS;  
B1JJF4, PIMT_YERPY;  

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