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ENZYME entry: EC 2.1.2.10

Accepted Name
Aminomethyltransferase.
Alternative Name(s)
Glycine synthase.
Glycine-cleavage system T-protein.
Tetrahydrofolate aminomethyltransferase.
Reaction catalysed
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate <=> [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3)
Comment(s)
  • A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.
  • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
Cross-references
BRENDA2.1.2.10
EC2PDB2.1.2.10
ExplorEnz2.1.2.10
PRIAM enzyme-specific profiles2.1.2.10
KEGG Ligand Database for Enzyme Nomenclature2.1.2.10
IUBMB Enzyme Nomenclature2.1.2.10
IntEnz2.1.2.10
MEDLINEFind literature relating to 2.1.2.10
MetaCyc2.1.2.10
UniProtKB/Swiss-Prot
C1F933, GCST_ACIC5;  A0KJ03, GCST_AERHH;  Q9YBA2, GCST_AERPE;  
A4SP35, GCST_AERS4;  Q0VLA6, GCST_ALCBS;  A6TMY6, GCST_ALKMQ;  
A8MEG4, GCST_ALKOO;  B4RSJ5, GCST_ALTMD;  B7GH71, GCST_ANOFW;  
O67441, GCST_AQUAE;  O65396, GCST_ARATH;  A7Z6M4, GCST_BACA2;  
C3P8D5, GCST_BACAA;  C3LKQ4, GCST_BACAC;  A0RIL1, GCST_BACAH;  
Q81M06, GCST_BACAN;  B7JMV1, GCST_BACC0;  Q730W1, GCST_BACC1;  
B7IXL4, GCST_BACC2;  C1ERV0, GCST_BACC3;  B7HBA0, GCST_BACC4;  
B7HNZ1, GCST_BACC7;  A7GSN8, GCST_BACCN;  B9IXL9, GCST_BACCQ;  
Q818M3, GCST_BACCR;  Q634V6, GCST_BACCZ;  Q5LFT6, GCST_BACFN;  
Q64WS3, GCST_BACFR;  Q9K934, GCST_BACHD;  Q6HDT6, GCST_BACHK;  
Q65HF9, GCST_BACLD;  A8FF41, GCST_BACP2;  Q5WF30, GCST_BACSK;  
P54378, GCST_BACSU;  Q89YZ6, GCST_BACTN;  A6L6X5, GCST_BACV8;  
A9VH12, GCST_BACWK;  Q6MQ03, GCST_BDEBA;  Q2KYM2, GCST_BORA1;  
Q7WP31, GCST_BORBR;  Q7W1C6, GCST_BORPA;  A9I7L6, GCST_BORPD;  
Q7W0E5, GCST_BORPE;  P25285, GCST_BOVIN;  B1YQQ3, GCST_BURA4;  
B1JSZ4, GCST_BURCC;  B4EF28, GCST_BURCJ;  A9ACU5, GCST_BURM1;  
A3MQP5, GCST_BURM7;  A2S6F4, GCST_BURM9;  Q62FM9, GCST_BURMA;  
A3P0U5, GCST_BURP0;  A3NEZ8, GCST_BURP6;  B2JJ71, GCST_BURP8;  
Q63PL4, GCST_BURPS;  Q39KT9, GCST_BURS3;  A4JA71, GCST_BURVG;  
Q9TSZ7, GCST_CANFA;  Q3AET7, GCST_CARHZ;  B3PI82, GCST_CELJU;  
P28337, GCST_CHICK;  Q3AQ17, GCST_CHLCH;  B3EFX7, GCST_CHLL2;  
B3QLF1, GCST_CHLP8;  A1BI02, GCST_CHLPD;  B3QV24, GCST_CHLT3;  
Q8KBJ9, GCST_CHLTE;  Q7NSJ3, GCST_CHRVO;  A8APB4, GCST_CITK8;  
A7FRV3, GCST_CLOB1;  C3L1M5, GCST_CLOB6;  C1FTW3, GCST_CLOBJ;  
B1IEV3, GCST_CLOBK;  A7GB83, GCST_CLOBL;  B1KWD5, GCST_CLOBM;  
Q486J8, GCST_COLP3;  C3PHK3, GCST_CORA7;  Q4JXU5, GCST_CORJK;  
Q83B06, GCST_COXBU;  A7MR82, GCST_CROS8;  Q0K5P5, GCST_CUPNH;  
Q46VZ7, GCST_CUPPJ;  B3R7J7, GCST_CUPTR;  B7K468, GCST_CYAP8;  
Q47D83, GCST_DECAR;  C1D0F7, GCST_DEIDV;  B8FT33, GCST_DESHD;  
Q24TH3, GCST_DESHY;  A4J2F6, GCST_DESRM;  Q54DD3, GCST_DICDI;  
A7ZR14, GCST_ECO24;  B7UHV3, GCST_ECO27;  B7MM91, GCST_ECO45;  
B7LF91, GCST_ECO55;  Q8XD32, GCST_ECO57;  B5YQ97, GCST_ECO5E;  
B7NHW6, GCST_ECO7I;  B7MZ57, GCST_ECO81;  B7LYG9, GCST_ECO8A;  
C5A0H7, GCST_ECOBW;  A8A446, GCST_ECOHS;  Q8FE65, GCST_ECOL6;  
B1IT97, GCST_ECOLC;  P27248, GCST_ECOLI;  B7N7E8, GCST_ECOLU;  
B6I738, GCST_ECOSE;  B1LDA5, GCST_ECOSM;  Q1R7C6, GCST_ECOUT;  
C5BAT2, GCST_EDWI9;  A4WE57, GCST_ENT38;  B2VF35, GCST_ERWT9;  
B7LPB9, GCST_ESCF3;  B1YLN6, GCST_EXIS2;  O49849, GCST_FLAAN;  
A6GXW3, GCST_FLAPJ;  P49363, GCST_FLAPR;  O23936, GCST_FLATR;  
Q0RFF6, GCST_FRAAA;  B0TZJ8, GCST_FRAP2;  A8LFB7, GCST_FRASN;  
Q14J42, GCST_FRAT1;  A7NAH6, GCST_FRATF;  Q2A4V3, GCST_FRATH;  
B2SFM1, GCST_FRATM;  A0Q585, GCST_FRATN;  Q0BN73, GCST_FRATO;  
Q5NHP0, GCST_FRATT;  A4IZK8, GCST_FRATW;  Q5KX76, GCST_GEOKA;  
C5D4A2, GCST_GEOSW;  A4IQV5, GCST_GEOTN;  Q7NFJ5, GCST_GLOVI;  
A1WWA3, GCST_HALHL;  Q5V230, GCST_HALMA;  B8D1D7, GCST_HALOH;  
B0R5Y8, GCST_HALS3;  Q9HPJ7, GCST_HALSA;  A9B2Q5, GCST_HERA2;  
P48728, GCST_HUMAN;  Q5QVA8, GCST_IDILO;  A6TDR7, GCST_KLEP7;  
Q1INT8, GCST_KORVE;  Q5X8W1, GCST_LEGPA;  A5I9T7, GCST_LEGPC;  
Q5ZZ93, GCST_LEGPH;  Q5X0A4, GCST_LEGPL;  B0SGN8, GCST_LEPBA;  
Q04PM9, GCST_LEPBJ;  Q055P6, GCST_LEPBL;  B0SQA1, GCST_LEPBP;  
Q72VI6, GCST_LEPIC;  Q8F935, GCST_LEPIN;  Q92C06, GCST_LISIN;  
C1L2Q4, GCST_LISMC;  Q71ZX4, GCST_LISMF;  B8DFY0, GCST_LISMH;  
Q8Y7D5, GCST_LISMO;  A0AIE9, GCST_LISW6;  B1HSN7, GCST_LYSSC;  
P93256, GCST_MESCR;  Q60BW3, GCST_METCA;  Q2RH46, GCST_MOOTA;  
Q8CFA2, GCST_MOUSE;  A0QEZ6, GCST_MYCA1;  P64221, GCST_MYCBO;  
B8ZQK6, GCST_MYCLB;  O32955, GCST_MYCLE;  Q73YK4, GCST_MYCPA;  
P9WN50, GCST_MYCTO;  P9WN51, GCST_MYCTU;  A0PTP8, GCST_MYCUA;  
Q3IN28, GCST_NATPD;  B2A2T4, GCST_NATTJ;  Q9JVP2, GCST_NEIMA;  
Q9K0L8, GCST_NEIMB;  Q0AEP7, GCST_NITEC;  Q82WQ6, GCST_NITEU;  
Q3JDS3, GCST_NITOC;  Q5YZ49, GCST_NOCFA;  Q8YNF7, GCST_NOSS1;  
Q8CXD9, GCST_OCEIH;  A6L8T3, GCST_PARD8;  P49364, GCST_PEA;  
Q6D976, GCST_PECAS;  C6D8W9, GCST_PECCP;  Q3B5U7, GCST_PELLD;  
B4SED4, GCST_PELPB;  Q7N197, GCST_PHOLL;  B2RI74, GCST_PORG3;  
Q7MUG4, GCST_PORGI;  B4S437, GCST_PROA2;  Q6A9R6, GCST_PROAC;  
A3PFH6, GCST_PROM0;  A2C5F7, GCST_PROM1;  A8G7J2, GCST_PROM2;  
A2CDX3, GCST_PROM3;  A2BZ74, GCST_PROM5;  Q7V9I2, GCST_PROMA;  
B4F0N9, GCST_PROMH;  Q7TUI6, GCST_PROMM;  Q7TU18, GCST_PROMP;  
A2BTR9, GCST_PROMS;  Q46I99, GCST_PROMT;  A4SDB4, GCST_PROVI;  
Q15PU4, GCST_PSEA6;  Q9HTX5, GCST_PSEAE;  Q3IFV9, GCST_PSEHT;  
Q88CI7, GCST_PSEPK;  Q88AS0, GCST_PSESM;  Q9UZP8, GCST_PYRAB;  
Q8U185, GCST_PYRFU;  O58888, GCST_PYRHO;  Q1LHM4, GCST_RALME;  
B2UG80, GCST_RALPJ;  Q8XUA0, GCST_RALSO;  Q1AR89, GCST_RUBXD;  
Q21NX7, GCST_SACD2;  A4FLG1, GCST_SACEN;  B5F5I0, GCST_SALA4;  
A9MRH0, GCST_SALAR;  Q57K60, GCST_SALCH;  B5FUG8, GCST_SALDC;  
B5QXI2, GCST_SALEP;  B5RE16, GCST_SALG2;  B4TGX5, GCST_SALHS;  
B4T550, GCST_SALNS;  Q5PJG4, GCST_SALPA;  A9N3N3, GCST_SALPB;  
C0PY28, GCST_SALPC;  B5BFM0, GCST_SALPK;  B4TV24, GCST_SALSV;  
P64223, GCST_SALTI;  P64222, GCST_SALTY;  O14110, GCST_SCHPO;  
A8GIS1, GCST_SERP5;  A1S967, GCST_SHEAM;  B8EB47, GCST_SHEB2;  
A3D083, GCST_SHEB5;  A6WSL3, GCST_SHEB8;  A9L332, GCST_SHEB9;  
Q12R04, GCST_SHEDO;  Q07YC7, GCST_SHEFN;  B0TSG7, GCST_SHEHH;  
A3QHI2, GCST_SHELP;  Q8EIQ8, GCST_SHEON;  A8H7T1, GCST_SHEPA;  
A4YAE0, GCST_SHEPC;  B8CK16, GCST_SHEPW;  A0L105, GCST_SHESA;  
A8FZK6, GCST_SHESH;  Q0HEX0, GCST_SHESM;  Q0HZ30, GCST_SHESR;  
A1RFY6, GCST_SHESW;  B1KG89, GCST_SHEWM;  B2U0S2, GCST_SHIB3;  
Q31WG6, GCST_SHIBS;  Q32BW7, GCST_SHIDS;  Q0T0Z3, GCST_SHIF8;  
Q83JU1, GCST_SHIFL;  Q3YXW5, GCST_SHISS;  Q2NRE8, GCST_SODGM;  
P54260, GCST_SOLTU;  A7X2S3, GCST_STAA1;  A6U208, GCST_STAA2;  
Q2FGI5, GCST_STAA3;  Q2FY33, GCST_STAA8;  A5IT65, GCST_STAA9;  
Q2YSZ2, GCST_STAAB;  Q5HFM2, GCST_STAAC;  A6QH81, GCST_STAAE;  
P64224, GCST_STAAM;  P64225, GCST_STAAN;  Q6GGG2, GCST_STAAR;  
Q6G929, GCST_STAAS;  A8Z476, GCST_STAAT;  P64226, GCST_STAAW;  
B9DNN7, GCST_STACT;  Q5HP12, GCST_STAEQ;  Q8CSF4, GCST_STAES;  
Q4L6N7, GCST_STAHJ;  Q49XY1, GCST_STAS1;  Q82JI2, GCST_STRAW;  
O86567, GCST_STRCO;  B4SSE0, GCST_STRM5;  B2FR21, GCST_STRMK;  
Q67N36, GCST_SYMTH;  Q31KT1, GCST_SYNE7;  B1XP99, GCST_SYNP2;  
Q5N136, GCST_SYNP6;  A5GPL8, GCST_SYNPW;  Q7TTS1, GCST_SYNPX;  
A5GWT1, GCST_SYNR3;  Q0I682, GCST_SYNS3;  Q3AVT0, GCST_SYNS9;  
P54261, GCST_SYNY3;  C5BM95, GCST_TERTT;  Q8DKV6, GCST_THEEB;  
C5A3P0, GCST_THEGJ;  Q5JDG3, GCST_THEKO;  A8F8M9, GCST_THELT;  
A6LP67, GCST_THEM4;  Q9WY54, GCST_THEMA;  B9K6R7, GCST_THENN;  
B6YY21, GCST_THEON;  A5IKL0, GCST_THEP1;  B0KD95, GCST_THEP3;  
B0K242, GCST_THEPX;  B1L9U1, GCST_THESQ;  Q72LB1, GCST_THET2;  
Q5SKX0, GCST_THET8;  Q8RCV9, GCST_THETN;  B8GNE2, GCST_THISH;  
Q8PI37, GCST_XANAC;  Q3BQN6, GCST_XANC5;  Q4UXC2, GCST_XANC8;  
Q8P6T8, GCST_XANCP;  Q2P4S5, GCST_XANOM;  B2SSQ1, GCST_XANOP;  
Q5H1X3, GCST_XANOR;  B2I6Q1, GCST_XYLF2;  Q9PGW5, GCST_XYLFA;  
B0U270, GCST_XYLFM;  Q87EZ6, GCST_XYLFT;  P48015, GCST_YEAST;  
A1JPN6, GCST_YERE8;  A7FF19, GCST_YERP3;  Q1CB44, GCST_YERPA;  
B2K0Q5, GCST_YERPB;  Q8ZHI6, GCST_YERPE;  A9R4K6, GCST_YERPG;  
Q1CEZ7, GCST_YERPN;  A4TIA5, GCST_YERPP;  Q666R5, GCST_YERPS;  
B1JNS6, GCST_YERPY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-