ENZYME entry: EC

Accepted Name
Mycocerosate synthase.
Reaction catalysed
  • A long-chain acyl-CoA + 3 methylmalonyl-CoA + 6 NADPH + a holo-[mycocerosate synthase] <=> a trimethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O
  • A long-chain acyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + a holo-[mycocerosate synthase] synthase <=> a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 5 CoA + 4 CO(2) + 8 NADP(+) + 4 H(2)O
  • This mycobacterial enzyme loads long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8- tetramethyloctacosanoate (C(32)-mycocerosate).
  • Since the enzyme lacks a thioesterase domain, the products remain bound to the enzyme and require additional enzyme(s) for removal.
  • Even though the enzyme can accept C(6) to C(20) substrates in vitro, it prefers to act on C(14)-C(20) substrates in vivo.
PRIAM enzyme-specific profiles2.3.1.111
KEGG Ligand Database for Enzyme Nomenclature2.3.1.111
IUBMB Enzyme Nomenclature2.3.1.111
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