ENZYME entry: EC 2.3.1.111

Accepted Name
Mycocerosate synthase.
Reaction catalysed
Acyl-CoA + n methylmalonyl-CoA + 2n NADPH <=> multi-methyl-branched acyl-CoA + n CoA + n CO(2) + 2n NADP(+) + n H(2)O
Comment(s)
  • This mycobacterial enzyme loads long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8- tetramethyloctacosanoate (C(32)-mycocerosate).
  • Since the enzyme lacks a thioesterase domain, the products remain bound to the enzyme and require additional enzyme(s) for removal.
  • Even though the enzyme can accept C(6) to C(20) substrates in vitro, it prefers to act on C(14)-C(20) substrates in vivo.
Cross-references
PROSITEPDOC00529
BRENDA2.3.1.111
EC2PDB2.3.1.111
ExplorEnz2.3.1.111
PRIAM enzyme-specific profiles2.3.1.111
KEGG Ligand Database for Enzyme Nomenclature2.3.1.111
IUBMB Enzyme Nomenclature2.3.1.111
IntEnz2.3.1.111
MEDLINEFind literature relating to 2.3.1.111
MetaCyc2.3.1.111
UniProtKB/Swiss-Prot
Q02251, MCAS_MYCBO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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