ENZYME entry: EC 2.3.1.180

Accepted Name
Beta-ketoacyl-acyl-carrier-protein synthase III.
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase III.
3-oxoacyl:ACP synthase III.
Beta-ketoacyl (acyl carrier protein) synthase III.
Beta-ketoacyl-ACP synthase III.
Beta-ketoacyl-acyl carrier protein synthase III.
KAS III.
KASIII.
Reaction catalysed
Acetyl-CoA + malonyl-[acyl-carrier-protein] <=> acetoacetyl-[acyl-carrier-protein] + CoA + CO(2)
Comment(s)
  • Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer.
  • In addition to the above reaction, the enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent.
  • Responsible for initiating both straight- and branched-chain fatty- acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism.
  • For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4--C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA.
Cross-references
BRENDA2.3.1.180
EC2PDB2.3.1.180
ExplorEnz2.3.1.180
PRIAM enzyme-specific profiles2.3.1.180
KEGG Ligand Database for Enzyme Nomenclature2.3.1.180
IUBMB Enzyme Nomenclature2.3.1.180
IntEnz2.3.1.180
MEDLINEFind literature relating to 2.3.1.180
MetaCyc2.3.1.180
UniProtKB/Swiss-Prot
Q81JG0, FABH1_BACAN;  Q81GM0, FABH1_BACCR;  Q9K8W9, FABH1_BACHD;  
O34746, FABH1_BACSU;  Q8ABI8, FABH1_BACTN;  P49244, FABH1_CUPWR;  
Q9RT23, FABH1_DEIRA;  Q88YZ4, FABH1_LACPL;  Q8CPT4, FABH1_STAES;  
Q82BB8, FABH1_STRAW;  P72392, FABH1_STRCO;  Q9KQH5, FABH1_VIBCH;  
Q87N20, FABH1_VIBPA;  Q8D8G6, FABH1_VIBVU;  Q7M7J9, FABH1_VIBVY;  
Q81JF6, FABH2_BACAN;  Q81F42, FABH2_BACCR;  Q9KET5, FABH2_BACHD;  
O07600, FABH2_BACSU;  Q8A137, FABH2_BACTN;  P49245, FABH2_CUPWR;  
Q9RT22, FABH2_DEIRA;  Q88WG8, FABH2_LACPL;  Q8CUB8, FABH2_STAES;  
Q82M29, FABH2_STRAW;  Q9Z4Y5, FABH2_STRCO;  Q9KLJ3, FABH2_VIBCH;  
Q87HJ2, FABH2_VIBPA;  Q8D719, FABH2_VIBVU;  Q7M7I3, FABH2_VIBVY;  
O54151, FABH3_STRCO;  Q9ZBV4, FABH4_STRCO;  Q9JN82, FABH5_STRCO;  
Q9PMZ6, FABHL_CAMJE;  B0CE67, FABH_ACAM1;  A9NFF0, FABH_ACHLI;  
B9MDQ9, FABH_ACIET;  B9JCY9, FABH_AGRRK;  Q8UG62, FABH_AGRT5;  
B9JV87, FABH_AGRVS;  O67185, FABH_AQUAE;  P49243, FABH_ARATH;  
B6YS41, FABH_AZOPC;  A1USI9, FABH_BARBK;  Q6G3K4, FABH_BARHE;  
Q6G000, FABH_BARQU;  A9IVB4, FABH_BART1;  Q7VR18, FABH_BLOFL;  
Q7WD20, FABH_BORBR;  Q7W5I4, FABH_BORPA;  A9IIH4, FABH_BORPD;  
Q7VW29, FABH_BORPE;  Q89K89, FABH_BRAJA;  B2S524, FABH_BRUA1;  
Q2YNB9, FABH_BRUA2;  Q57DX4, FABH_BRUAB;  A9MAF6, FABH_BRUC2;  
C0RIB3, FABH_BRUMB;  Q8YGH9, FABH_BRUME;  A5VPV8, FABH_BRUO2;  
B0CLA2, FABH_BRUSI;  Q8G1E0, FABH_BRUSU;  B1JYA0, FABH_BURCC;  
B2JFI9, FABH_BURP8;  A4XJW0, FABH_CALS8;  Q9PIH1, FABH_CAMJE;  
Q9A8I4, FABH_CAUCR;  Q820E6, FABH_CHLCV;  Q9PKF5, FABH_CHLMU;  
Q9Z8P0, FABH_CHLPN;  Q8KAP2, FABH_CHLTE;  O84242, FABH_CHLTR;  
Q7NSK7, FABH_CHRVO;  Q97DA2, FABH_CLOAB;  C3KWF7, FABH_CLOB6;  
A6LSC2, FABH_CLOB8;  C1FNK7, FABH_CLOBJ;  B1IHN1, FABH_CLOBK;  
B1KU74, FABH_CLOBM;  B9DY04, FABH_CLOK1;  A5N4E1, FABH_CLOK5;  
Q8XLH3, FABH_CLOPE;  Q899P3, FABH_CLOTE;  B6J8E5, FABH_COXB1;  
B6J1I6, FABH_COXB2;  A9KEA1, FABH_COXBN;  A9NBY3, FABH_COXBR;  
Q820X0, FABH_COXBU;  B3R213, FABH_CUPTR;  C1D0N4, FABH_DEIDV;  
Q1J198, FABH_DEIGD;  A9BNK6, FABH_DELAS;  B8FRS6, FABH_DESHD;  
Q24U40, FABH_DESHY;  B8DJG1, FABH_DESVM;  A5EXD7, FABH_DICNV;  
A8LLT4, FABH_DINSH;  P0A6R2, FABH_ECO57;  P0A6R1, FABH_ECOL6;  
B1IUH4, FABH_ECOLC;  P0A6R0, FABH_ECOLI;  Q820T1, FABH_ENTFA;  
Q6D690, FABH_ERWCT;  Q2N925, FABH_ERYLH;  Q8RGX7, FABH_FUSNN;  
Q7NF35, FABH_GLOVI;  Q6B945, FABH_GRATL;  Q7U337, FABH_HAEDU;  
P43711, FABH_HAEIN;  B0UUZ0, FABH_HAES2;  P59813, FABH_HELHP;  
B6JKD5, FABH_HELP2;  B5Z9X2, FABH_HELPG;  Q9ZMN0, FABH_HELPJ;  
B2US32, FABH_HELPS;  O24994, FABH_HELPY;  B2GFZ7, FABH_KOCRD;  
Q1GAG1, FABH_LACDA;  Q04AU8, FABH_LACDB;  Q9CHG0, FABH_LACLA;  
A5VK78, FABH_LACRD;  B2G7L1, FABH_LACRJ;  C1DCE8, FABH_LARHH;  
Q929H1, FABH_LISIN;  Q71XG3, FABH_LISMF;  Q8Y573, FABH_LISMO;  
Q11J83, FABH_MESSB;  Q606L3, FABH_METCA;  B0JXE2, FABH_MICAN;  
B1MKD7, FABH_MYCA9;  P0A575, FABH_MYCBO;  C1AKL3, FABH_MYCBT;  
B2HRM4, FABH_MYCMM;  Q73SP5, FABH_MYCPA;  P0A574, FABH_MYCTU;  
B2A2M5, FABH_NATTJ;  B4RJI1, FABH_NEIG2;  A9M142, FABH_NEIM0;  
Q9JW56, FABH_NEIMA;  Q9JXR6, FABH_NEIMB;  Q82U60, FABH_NITEU;  
Q2YA46, FABH_NITMU;  Q8Z062, FABH_NOSS1;  Q8ERU6, FABH_OCEIH;  
A6X1X8, FABH_OCHA4;  Q04DM7, FABH_OENOB;  Q9CJS8, FABH_PASMU;  
C0QPF4, FABH_PERMH;  Q7N384, FABH_PHOLL;  B1XTK6, FABH_POLNS;  
A4SVV4, FABH_POLSQ;  B2RH63, FABH_PORG3;  Q7MAV3, FABH_PORGI;  
P51196, FABH_PORPU;  P31176, FABH_PORUM;  Q1XDU1, FABH_PORYE;  
Q7VE55, FABH_PROMA;  Q7V4F6, FABH_PROMM;  Q7V3E0, FABH_PROMP;  
A4SCL4, FABH_PROVI;  B7V4R0, FABH_PSEA8;  Q9HYR2, FABH_PSEAE;  
B2U968, FABH_RALPJ;  Q8Y0J4, FABH_RALSO;  Q1MIS6, FABH_RHIL3;  
Q982Z8, FABH_RHILO;  Q92QT4, FABH_RHIME;  P59814, FABH_RHOBA;  
P30790, FABH_RHOCA;  B6IMR5, FABH_RHOCS;  Q2RTS8, FABH_RHORT;  
Q1RKA5, FABH_RICBR;  Q92GC1, FABH_RICCN;  Q4UK49, FABH_RICFE;  
Q9ZCH1, FABH_RICPR;  B0BV80, FABH_RICRO;  Q68VX7, FABH_RICTY;  
A7NK75, FABH_ROSCS;  A5UWI7, FABH_ROSS1;  A9MGC9, FABH_SALAR;  
A9N5L3, FABH_SALPB;  Q8Z7J6, FABH_SALTI;  O85139, FABH_SALTY;  
Q8EDH1, FABH_SHEON;  Q83RS8, FABH_SHIFL;  A6U7Q5, FABH_SINMW;  
Q01QV9, FABH_SOLUE;  A5VC86, FABH_SPHWW;  Q07510, FABH_SPIOL;  
A6U089, FABH_STAA2;  A5IRG0, FABH_STAA9;  Q5HHA2, FABH_STAAC;  
P68795, FABH_STAAM;  P99159, FABH_STAAN;  Q6GIA4, FABH_STAAR;  
Q6GAU3, FABH_STAAS;  A8Z088, FABH_STAAT;  Q8NXE2, FABH_STAAW;  
Q5HQI2, FABH_STAEQ;  Q4L4Z3, FABH_STAHJ;  Q49WB6, FABH_STAS1;  
P64112, FABH_STRA3;  P64113, FABH_STRA5;  C0M7U3, FABH_STRE4;  
B4U1B3, FABH_STREM;  Q54206, FABH_STRGA;  A8AYW5, FABH_STRGC;  
Q9F6D4, FABH_STRLI;  Q8DSN2, FABH_STRMU;  Q99YD2, FABH_STRP1;  
P0DB00, FABH_STRP3;  B5E7F8, FABH_STRP4;  Q5XAE0, FABH_STRP6;  
C1C5F4, FABH_STRP7;  P64115, FABH_STRP8;  B1I9L1, FABH_STRPI;  
B8ZLI3, FABH_STRPJ;  P0A3C5, FABH_STRPN;  P0DB01, FABH_STRPQ;  
B2ILW2, FABH_STRPS;  B5XHY5, FABH_STRPZ;  P0A3C6, FABH_STRR6;  
C0ME18, FABH_STRS7;  B9DVE9, FABH_STRU0;  C1CCI2, FABH_STRZJ;  
C1CIR8, FABH_STRZP;  C1CPS7, FABH_STRZT;  A6QBY0, FABH_SULNB;  
Q67PG0, FABH_SYMTH;  P73951, FABH_SYNY3;  Q8DKL4, FABH_THEEB;  
Q8R9V7, FABH_THETN;  B8GSX7, FABH_THISH;  P64117, FABH_TROW8;  
P64116, FABH_TROWT;  C5CSE2, FABH_VARPS;  Q73GG9, FABH_WOLPM;  
B3CML1, FABH_WOLPP;  Q8PNE8, FABH_XANAC;  Q8PBV1, FABH_XANCP;  
Q9PCG4, FABH_XYLFA;  Q87CL7, FABH_XYLFT;  Q8ZFT7, FABH_YERPE;  
P20582, PQSD_PSEAE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
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