To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.3.1.180

Accepted Name
Beta-ketoacyl-[acyl-carrier-protein] synthase III.
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase III.
3-oxoacyl:ACP synthase III.
Beta-ketoacyl (acyl carrier protein) synthase III.
Beta-ketoacyl-ACP synthase III.
Beta-ketoacyl-acyl carrier protein synthase III.
KAS III.
KASIII.
Reaction catalysed
Acetyl-CoA + malonyl-[acyl-carrier-protein] <=> acetoacetyl-[acyl-carrier-protein] + CoA + CO(2)
Comment(s)
  • Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer.
  • In addition to the above reaction, the enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent.
  • Responsible for initiating both straight- and branched-chain fatty- acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism.
  • For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4--C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA.
Cross-references
BRENDA2.3.1.180
EC2PDB2.3.1.180
ExplorEnz2.3.1.180
PRIAM enzyme-specific profiles2.3.1.180
KEGG Ligand Database for Enzyme Nomenclature2.3.1.180
IUBMB Enzyme Nomenclature2.3.1.180
IntEnz2.3.1.180
MEDLINEFind literature relating to 2.3.1.180
MetaCyc2.3.1.180
UniProtKB/Swiss-Prot
Q81JG0, FABH1_BACAN;  Q81GM0, FABH1_BACCR;  Q9K8W9, FABH1_BACHD;  
O34746, FABH1_BACSU;  Q8ABI8, FABH1_BACTN;  P49244, FABH1_CUPWR;  
Q9RT23, FABH1_DEIRA;  Q88YZ4, FABH1_LACPL;  Q8CPT4, FABH1_STAES;  
Q82BB8, FABH1_STRAW;  P72392, FABH1_STRCO;  Q9KQH5, FABH1_VIBCH;  
Q87N20, FABH1_VIBPA;  Q8D8G6, FABH1_VIBVU;  Q7M7J9, FABH1_VIBVY;  
Q81JF6, FABH2_BACAN;  Q81F42, FABH2_BACCR;  Q9KET5, FABH2_BACHD;  
O07600, FABH2_BACSU;  Q8A137, FABH2_BACTN;  P49245, FABH2_CUPWR;  
Q9RT22, FABH2_DEIRA;  Q88WG8, FABH2_LACPL;  Q8CUB8, FABH2_STAES;  
Q82M29, FABH2_STRAW;  Q9Z4Y5, FABH2_STRCO;  Q9KLJ3, FABH2_VIBCH;  
Q87HJ2, FABH2_VIBPA;  Q8D719, FABH2_VIBVU;  Q7M7I3, FABH2_VIBVY;  
O54151, FABH3_STRCO;  Q9ZBV4, FABH4_STRCO;  Q9JN82, FABH5_STRCO;  
Q9PMZ6, FABHL_CAMJE;  B0CE67, FABH_ACAM1;  A9NFF0, FABH_ACHLI;  
A1TLD7, FABH_ACIAC;  A5FV65, FABH_ACICJ;  B9MDQ9, FABH_ACIET;  
A1WAX8, FABH_ACISJ;  A3N232, FABH_ACTP2;  A6VQV2, FABH_ACTSZ;  
Q8UG62, FABH_AGRFC;  B9JCY9, FABH_AGRRK;  B9JV87, FABH_AGRVS;  
Q0A8R5, FABH_ALKEH;  Q5PA98, FABH_ANAMM;  Q3M9J4, FABH_ANAVT;  
O67185, FABH_AQUAE;  P49243, FABH_ARATH;  A8ERJ6, FABH_ARCB4;  
Q5P0D6, FABH_AROAE;  B6YS41, FABH_AZOPC;  A1K5Y5, FABH_AZOSB;  
A8FBX4, FABH_BACP2;  A6KXK3, FABH_BACV8;  A1USI9, FABH_BARBK;  
Q6G3K4, FABH_BARHE;  Q6G000, FABH_BARQU;  A9IVB4, FABH_BART1;  
Q1LT37, FABH_BAUCH;  Q7VR18, FABH_BLOFL;  Q492Q4, FABH_BLOPB;  
Q2KUK5, FABH_BORA1;  Q7WD20, FABH_BORBR;  Q7W5I4, FABH_BORPA;  
A9IIH4, FABH_BORPD;  Q7VW29, FABH_BORPE;  Q89K89, FABH_BRADU;  
A5EKG5, FABH_BRASB;  A4YW84, FABH_BRASO;  B2S524, FABH_BRUA1;  
Q2YNB9, FABH_BRUA2;  Q57DX4, FABH_BRUAB;  A9MAF6, FABH_BRUC2;  
C0RIB3, FABH_BRUMB;  Q8YGH9, FABH_BRUME;  A5VPV8, FABH_BRUO2;  
B0CLA2, FABH_BRUSI;  Q8G1E0, FABH_BRUSU;  Q1BXV4, FABH_BURCA;  
B1JYA0, FABH_BURCC;  A0K5U6, FABH_BURCH;  Q39I86, FABH_BURL3;  
A3MM55, FABH_BURM7;  A2S9Y2, FABH_BURM9;  Q62LU2, FABH_BURMA;  
A1V6D0, FABH_BURMS;  A3NXM9, FABH_BURP0;  Q3JQ65, FABH_BURP1;  
A3NBU2, FABH_BURP6;  Q63S83, FABH_BURPS;  Q2SXU7, FABH_BURTA;  
A4JCP8, FABH_BURVG;  Q8R9V7, FABH_CALS4;  A4XJW0, FABH_CALS8;  
A7ZC01, FABH_CAMC1;  A7H054, FABH_CAMC5;  A0RMK8, FABH_CAMFF;  
A7I3D6, FABH_CAMHC;  A8FKB7, FABH_CAMJ8;  A7H541, FABH_CAMJD;  
Q9PIH1, FABH_CAMJE;  A1VY47, FABH_CAMJJ;  Q5HWE3, FABH_CAMJR;  
Q9A8I4, FABH_CAUCR;  Q11J83, FABH_CHESB;  Q3AQ09, FABH_CHLCH;  
Q820E6, FABH_CHLCV;  Q3B6K8, FABH_CHLL7;  Q9PKF5, FABH_CHLMU;  
A1BJA1, FABH_CHLPD;  A4SCL4, FABH_CHLPM;  Q9Z8P0, FABH_CHLPN;  
Q3KMC3, FABH_CHLTA;  Q8KAP2, FABH_CHLTE;  O84242, FABH_CHLTR;  
Q7NSK7, FABH_CHRVO;  A8AHY1, FABH_CITK8;  Q97DA2, FABH_CLOAB;  
A7FPM6, FABH_CLOB1;  C3KWF7, FABH_CLOB6;  A6LSC2, FABH_CLOB8;  
A5I7X8, FABH_CLOBH;  C1FNK7, FABH_CLOBJ;  B1IHN1, FABH_CLOBK;  
A7GJJ9, FABH_CLOBL;  B1KU74, FABH_CLOBM;  B9DY04, FABH_CLOK1;  
A5N4E1, FABH_CLOK5;  A0PXB6, FABH_CLONN;  Q0TRH0, FABH_CLOP1;  
Q8XLH3, FABH_CLOPE;  Q0STU9, FABH_CLOPS;  Q899P3, FABH_CLOTE;  
B6J8E5, FABH_COXB1;  B6J1I6, FABH_COXB2;  A9KEA1, FABH_COXBN;  
A9NBY3, FABH_COXBR;  Q820X0, FABH_COXBU;  A7MFQ4, FABH_CROS8;  
Q0K8L9, FABH_CUPNH;  Q46Z05, FABH_CUPNJ;  B3R213, FABH_CUPTR;  
C1D0N4, FABH_DEIDV;  Q1J198, FABH_DEIGD;  A9BNK6, FABH_DELAS;  
Q30YM1, FABH_DESAG;  B8FRS6, FABH_DESHD;  Q24U40, FABH_DESHY;  
Q6AJF8, FABH_DESPS;  Q72CS6, FABH_DESVH;  B8DJG1, FABH_DESVM;  
A1VEK1, FABH_DESVV;  A5EXD7, FABH_DICNV;  A8LLT4, FABH_DINSH;  
A7ZKJ4, FABH_ECO24;  P0A6R2, FABH_ECO57;  A7ZZ48, FABH_ECOHS;  
A1A9Y5, FABH_ECOK1;  Q0TIY3, FABH_ECOL5;  P0A6R1, FABH_ECOL6;  
B1IUH4, FABH_ECOLC;  P0A6R0, FABH_ECOLI;  Q1RD66, FABH_ECOUT;  
Q3YRP7, FABH_EHRCJ;  Q2GH17, FABH_EHRCR;  Q5FFP2, FABH_EHRRG;  
Q5HAV9, FABH_EHRRW;  A4W9A5, FABH_ENT38;  Q820T1, FABH_ENTFA;  
Q2N925, FABH_ERYLH;  Q8RGX7, FABH_FUSNN;  Q5L1U1, FABH_GEOKA;  
Q7NF35, FABH_GLOVI;  Q0BTE0, FABH_GRABC;  Q6B945, FABH_GRATL;  
Q7U337, FABH_HAEDU;  Q4QP30, FABH_HAEI8;  A5UFW1, FABH_HAEIG;  
P43711, FABH_HAEIN;  Q0I0V6, FABH_HAES1;  Q17YQ2, FABH_HELAH;  
P59813, FABH_HELHP;  B6JKD5, FABH_HELP2;  B5Z9X2, FABH_HELPG;  
Q1CUV9, FABH_HELPH;  Q9ZMN0, FABH_HELPJ;  B2US32, FABH_HELPS;  
O24994, FABH_HELPY;  A4G6T2, FABH_HERAR;  B0UUZ0, FABH_HISS2;  
Q0C312, FABH_HYPNA;  A6SXP9, FABH_JANMA;  Q28RG1, FABH_JANSC;  
A6T7F1, FABH_KLEP7;  B2GFZ7, FABH_KOCRD;  Q1IQ32, FABH_KORVE;  
Q03RV2, FABH_LACBA;  Q1GAG1, FABH_LACDA;  Q04AU8, FABH_LACDB;  
A8YXS0, FABH_LACH4;  Q9CHG0, FABH_LACLA;  A2RM32, FABH_LACLM;  
Q030J8, FABH_LACLS;  A5VK78, FABH_LACRD;  B2G7L1, FABH_LACRJ;  
Q38XG4, FABH_LACSS;  C1DCE8, FABH_LARHH;  Q929H1, FABH_LISIN;  
Q71XG3, FABH_LISMF;  Q8Y573, FABH_LISMO;  A0AKV5, FABH_LISW6;  
Q2W4R7, FABH_MAGSA;  A1U0E3, FABH_MARHV;  Q606L3, FABH_METCA;  
B0JXE2, FABH_MICAN;  A0QLF3, FABH_MYCA1;  B1MKD7, FABH_MYCA9;  
P0A575, FABH_MYCBO;  A1KG10, FABH_MYCBP;  C1AKL3, FABH_MYCBT;  
B2HRM4, FABH_MYCMM;  Q73SP5, FABH_MYCPA;  A5TZR3, FABH_MYCTA;  
P9WNG2, FABH_MYCTO;  P9WNG3, FABH_MYCTU;  A0PLS8, FABH_MYCUA;  
B2A2M5, FABH_NATTJ;  Q5F4X5, FABH_NEIG1;  B4RJI1, FABH_NEIG2;  
A9M142, FABH_NEIM0;  Q9JW56, FABH_NEIMA;  Q9JXR6, FABH_NEIMB;  
A1KRY9, FABH_NEIMF;  Q2GDD8, FABH_NEOSM;  Q0AIS4, FABH_NITEC;  
Q82U60, FABH_NITEU;  Q2YA46, FABH_NITMU;  Q8Z062, FABH_NOSS1;  
Q2G5S1, FABH_NOVAD;  Q8ERU6, FABH_OCEIH;  A6X1X8, FABH_OCHA4;  
Q04DM7, FABH_OENOB;  A6LEP7, FABH_PARD8;  A1B364, FABH_PARDP;  
B2JFI9, FABH_PARP8;  Q9CJS8, FABH_PASMU;  Q6D690, FABH_PECAS;  
Q18B40, FABH_PEPD6;  C0QPF4, FABH_PERMH;  Q7N384, FABH_PHOLL;  
A4SVV4, FABH_POLAQ;  A1VRU7, FABH_POLNA;  B1XTK6, FABH_POLNS;  
Q126I8, FABH_POLSJ;  B2RH63, FABH_PORG3;  Q7MAV3, FABH_PORGI;  
P51196, FABH_PORPU;  P31176, FABH_PORUM;  A3PAK3, FABH_PROM0;  
A8G2E1, FABH_PROM2;  A2BUB2, FABH_PROM5;  Q31D45, FABH_PROM9;  
Q7VE55, FABH_PROMA;  Q7V4F6, FABH_PROMM;  Q7V3E0, FABH_PROMP;  
Q46HN8, FABH_PROMT;  Q15TZ6, FABH_PSEA6;  B7V4R0, FABH_PSEA8;  
Q02QG7, FABH_PSEAB;  Q9HYR2, FABH_PSEAE;  Q3IBW0, FABH_PSEHT;  
A1STW1, FABH_PSYIN;  Q1XDU1, FABH_PYRYE;  B2U968, FABH_RALPJ;  
Q8Y0J4, FABH_RALSO;  Q1MIS6, FABH_RHIL3;  Q982Z8, FABH_RHILO;  
Q92QT4, FABH_RHIME;  P59814, FABH_RHOBA;  P30790, FABH_RHOCA;  
B6IMR5, FABH_RHOCS;  Q21XP4, FABH_RHOFT;  Q2RTS8, FABH_RHORT;  
A3PJ64, FABH_RHOS1;  Q3J365, FABH_RHOS4;  A4WTT9, FABH_RHOS5;  
A8GPW1, FABH_RICAH;  A8GY06, FABH_RICB8;  Q1RKA5, FABH_RICBR;  
A8EZX3, FABH_RICCK;  Q92GC1, FABH_RICCN;  Q4UK49, FABH_RICFE;  
A8F2R3, FABH_RICM5;  Q9ZCH1, FABH_RICPR;  B0BV80, FABH_RICRO;  
A8GTP2, FABH_RICRS;  Q68VX7, FABH_RICTY;  A7NK75, FABH_ROSCS;  
Q164C9, FABH_ROSDO;  A5UWI7, FABH_ROSS1;  Q1AW87, FABH_RUBXD;  
Q5LQJ5, FABH_RUEPO;  Q1GI69, FABH_RUEST;  A9MGC9, FABH_SALAR;  
Q57QG4, FABH_SALCH;  Q5PGU1, FABH_SALPA;  A9N5L3, FABH_SALPB;  
Q8Z7J6, FABH_SALTI;  O85139, FABH_SALTY;  A8GD17, FABH_SERP5;  
Q8EDH1, FABH_SHEON;  Q31ZE6, FABH_SHIBS;  Q32EV1, FABH_SHIDS;  
Q0T5U5, FABH_SHIF8;  Q83RS8, FABH_SHIFL;  Q3Z326, FABH_SHISS;  
A6U7Q5, FABH_SINMW;  Q2NU42, FABH_SODGM;  Q01QV9, FABH_SOLUE;  
Q1GT90, FABH_SPHAL;  A5VC86, FABH_SPHWW;  Q07510, FABH_SPIOL;  
A7X0K2, FABH_STAA1;  A6U089, FABH_STAA2;  Q2FI93, FABH_STAA3;  
Q2FZS0, FABH_STAA8;  A5IRG0, FABH_STAA9;  Q2YWV3, FABH_STAAB;  
Q5HHA2, FABH_STAAC;  A6QFJ3, FABH_STAAE;  P68795, FABH_STAAM;  
P99159, FABH_STAAN;  Q6GIA4, FABH_STAAR;  Q6GAU3, FABH_STAAS;  
A8Z088, FABH_STAAT;  Q8NXE2, FABH_STAAW;  Q5HQI2, FABH_STAEQ;  
Q4L4Z3, FABH_STAHJ;  Q49WB6, FABH_STAS1;  Q3K338, FABH_STRA1;  
P64112, FABH_STRA3;  P64113, FABH_STRA5;  C0M7U3, FABH_STRE4;  
B4U1B3, FABH_STREM;  Q54206, FABH_STRGA;  A8AYW5, FABH_STRGC;  
Q9F6D4, FABH_STRLI;  Q8DSN2, FABH_STRMU;  Q99YD2, FABH_STRP1;  
Q04M58, FABH_STRP2;  P0DB00, FABH_STRP3;  B5E7F8, FABH_STRP4;  
Q5XAE0, FABH_STRP6;  C1C5F4, FABH_STRP7;  P64115, FABH_STRP8;  
Q1JA87, FABH_STRPB;  Q1JKE0, FABH_STRPC;  Q1JFD2, FABH_STRPD;  
Q1J582, FABH_STRPF;  A2RCX0, FABH_STRPG;  B1I9L1, FABH_STRPI;  
B8ZLI3, FABH_STRPJ;  Q48RR7, FABH_STRPM;  P0A3C5, FABH_STRPN;  
P0DB01, FABH_STRPQ;  B2ILW2, FABH_STRPS;  B5XHY5, FABH_STRPZ;  
P0A3C6, FABH_STRR6;  A4W3N0, FABH_STRS2;  C0ME18, FABH_STRS7;  
A3CQ60, FABH_STRSV;  A4VXD4, FABH_STRSY;  Q5M184, FABH_STRT1;  
Q5M5S1, FABH_STRT2;  Q03M55, FABH_STRTD;  B9DVE9, FABH_STRU0;  
C1CCI2, FABH_STRZJ;  C1CIR8, FABH_STRZP;  C1CPS7, FABH_STRZT;  
Q30PN6, FABH_SULDN;  A6QBY0, FABH_SULNB;  Q67PG0, FABH_SYMTH;  
Q31N84, FABH_SYNE7;  Q5N5X5, FABH_SYNP6;  A5GP11, FABH_SYNPW;  
A5GQJ2, FABH_SYNR3;  Q0AVV3, FABH_SYNWW;  P73951, FABH_SYNY3;  
Q8DKL4, FABH_THEEB;  Q3SIM4, FABH_THIDA;  B8GSX7, FABH_THISH;  
Q114K0, FABH_TRIEI;  P64117, FABH_TROW8;  P64116, FABH_TROWT;  
C5CSE2, FABH_VARPS;  A1WMX5, FABH_VEREI;  A5CWU7, FABH_VESOH;  
Q5E409, FABH_VIBF1;  Q73GG9, FABH_WOLPM;  B3CML1, FABH_WOLPP;  
Q5GS22, FABH_WOLTR;  Q8PNE8, FABH_XANAC;  Q3BWI9, FABH_XANC5;  
Q4URQ0, FABH_XANC8;  Q8PBV1, FABH_XANCP;  Q2P7B9, FABH_XANOM;  
Q9PCG4, FABH_XYLFA;  Q87CL7, FABH_XYLFT;  A1JN67, FABH_YERE8;  
A7FH25, FABH_YERP3;  Q1C6M8, FABH_YERPA;  Q8ZFT7, FABH_YERPE;  
Q1CI19, FABH_YERPN;  A4TLS3, FABH_YERPP;  Q669L1, FABH_YERPS;  
Q9HU15, FABY_PSEAE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-