ENZYME entry: EC 2.3.1.184

Accepted Name
Acyl-homoserine-lactone synthase.
Alternative Name(s)
Acyl homoserine lactone synthase.
Acyl-homoserine lactone synthase.
Acyl-homoserinelactone synthase.
Acylhomoserine lactone synthase.
AHL synthase.
AHSL synthase.
Autoinducer synthase.
Autoinducer synthesis protein.
N-acyl homoserine lactone synthase.
Reaction catalysed
An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine <=> [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier- protein] are the best substrates.
  • The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA.
  • S-adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.
Cross-references
PROSITEPDOC51186
BRENDA2.3.1.184
EC2PDB2.3.1.184
ExplorEnz2.3.1.184
PRIAM enzyme-specific profiles2.3.1.184
KEGG Ligand Database for Enzyme Nomenclature2.3.1.184
IUBMB Enzyme Nomenclature2.3.1.184
IntEnz2.3.1.184
MEDLINEFind literature relating to 2.3.1.184
MetaCyc2.3.1.184
UniProtKB/Swiss-Prot
B0FLN1, ABAI_ACIBA;  Q44058, AHYI_AERHY;  A0A0A7XNA3, ANOI_ACINO;  
P70774, ASAI_AERSA;  P33880, CARI_PECCC;  P33881, EAGI_ENTAG;  
Q46968, ECHI_DICCH;  P54656, ESAI_PANSE;  Q47187, EXPI_DICD3;  
P33882, EXPI_PECSS;  P33883, LASI_PSEAE;  P12747, LUXI_ALIFS;  
P35328, LUXJ_VIBF1;  A7MRY3, LUXM_VIBCB;  P54298, LUXM_VIBHA;  
B7VQM9, LUXM_VIBTL;  Q87NA8, OPAM_VIBPA;  Q51522, PHZI_PSECL;  
Q51785, PHZI_PSEFL;  P52990, PSYI_PSEAJ;  O54451, RAII_RHIET;  
P54291, RHLI_PSEAE;  O30920, SOLI_RALSL;  P58584, SOLI_RALSO;  
P52989, SWRI_SERLI;  P33907, TRAI_AGRFC;  P33904, TRAI_RHIRD;  
P55394, TRAI_SINFN;  P74945, VANI_VIBAN;  Q9FDA3, VANM_VIBAN;  
P52988, YENI_YEREN;  O87970, YUKI_YERRU;  

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