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ENZYME entry: EC 188.8.131.52
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|Acyl homoserine lactone synthase.|
|Acyl-homoserine lactone synthase.|
|Acylhomoserine lactone synthase.|
|Autoinducer synthesis protein.|
|N-acyl homoserine lactone synthase.|
|An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine <=> [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone|
- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial
species and are used by them to regulate the expression of virulence
genes in a process known as quorum-sensing.
- Each bacterial cell has a basal level of AHL and, once the population
density reaches a critical level, it triggers AHL-signaling which,
in turn, initiates the expression of particular virulence genes.
- N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier-
protein] are the best substrates.
- The fatty-acyl substrate is derived from fatty-acid biosynthesis
through acyl-[acyl-carrier-protein] rather than from fatty-acid
degradation through acyl-CoA.
- S-adenosyl-L-methionine cannot be replaced by methionine,
S-adenosylhomocysteine, homoserine or homoserine lactone.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|B0FLN1, ABAI_ACIBA; ||Q44058, AHYI_AERHY; ||A0A0A7XNA3, ANOI_ACINO; |
|P70774, ASAI_AERSA; ||P33880, CARI_PECCC; ||P33881, EAGI_ENTAG; |
|Q46968, ECHI_DICCH; ||P54656, ESAI_PANSE; ||Q47187, EXPI_DICD3; |
|P33882, EXPI_PECSS; ||P33883, LASI_PSEAE; ||P12747, LUXI_ALIFS; |
|P35328, LUXJ_VIBF1; ||A7MRY3, LUXM_VIBCB; ||P54298, LUXM_VIBHA; |
|B7VQM9, LUXM_VIBTL; ||Q87NA8, OPAM_VIBPA; ||Q51522, PHZI_PSECL; |
|Q51785, PHZI_PSEFL; ||P52990, PSYI_PSEAJ; ||O54451, RAII_RHIET; |
|P54291, RHLI_PSEAE; ||O30920, SOLI_RALSL; ||P58584, SOLI_RALSO; |
|P52989, SWRI_SERLI; ||P33907, TRAI_AGRFC; ||P33904, TRAI_RHIRD; |
|P55394, TRAI_SINFN; ||P74945, VANI_VIBAN; ||Q9FDA3, VANM_VIBAN; |
|P52988, YENI_YEREN; ||O87970, YUKI_YERRU; |
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