ENZYME entry: EC 2.3.1.230

Accepted Name
2-heptyl-4(1H)-quinolone synthase.
Reaction catalysed
  • 3-oxodecanoate + anthraniloyl-CoA <=> CoA + 2-heptyl-4(1H)-quinolone + CO(2) + H(2)O
  • Malonyl-CoA + anthraniloyl-CoA <=> 2 CoA + 4-hydroxy-2(1H)-quinolone + CO(2)
Comment(s)
  • The enzyme from the Gram-negative bacterium Pseudomonas aeruginosa is involved in the biosynthesis of 2-heptyl-4-hydroxyquinoline and 2,4- dihydroxyquinoline.
  • 2-heptyl-4-hydroxyquinoline is a signal molecule, that is involved in regulation of virulence factor production and biofilm formation.
  • The enzyme shows a broad specificity and is involved in the synthesis of a wide array of additional 2-alkyl-4(1H)-quinolones synthesized by the organism.
Cross-references
BRENDA2.3.1.230
EC2PDB2.3.1.230
ExplorEnz2.3.1.230
PRIAM enzyme-specific profiles2.3.1.230
KEGG Ligand Database for Enzyme Nomenclature2.3.1.230
IUBMB Enzyme Nomenclature2.3.1.230
IntEnz2.3.1.230
MEDLINEFind literature relating to 2.3.1.230
MetaCyc2.3.1.230
UniProtKB/Swiss-Prot
P20582, PQSD_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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