ENZYME entry: EC 2.3.1.240

Accepted Name
Narbonolide synthase.
Alternative Name(s)
Pikromycin PKS.
Reaction catalysed
Malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH <=> narbonolide + 7 CoA + 7 CO(2) + 5 NADP(+) + 2 H(2)O
Comment(s)
  • The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae.
  • The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239).
  • The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • Not all active sites are used in the biosynthesis.
Cross-references
BRENDA2.3.1.240
EC2PDB2.3.1.240
ExplorEnz2.3.1.240
PRIAM enzyme-specific profiles2.3.1.240
KEGG Ligand Database for Enzyme Nomenclature2.3.1.240
IUBMB Enzyme Nomenclature2.3.1.240
IntEnz2.3.1.240
MEDLINEFind literature relating to 2.3.1.240
MetaCyc2.3.1.240
UniProtKB/Swiss-Prot
Q9ZGI5, PIKA1_STRVZ;  Q9ZGI4, PIKA2_STRVZ;  Q9ZGI3, PIKA3_STRVZ;  
Q9ZGI2, PIKA4_STRVZ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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