ENZYME entry: EC 2.3.1.39

Accepted Name
[Acyl-carrier-protein] S-malonyltransferase.
Alternative Name(s)
Acyl carrier protein malonyltransferase.
Malonyl coenzyme A-acyl carrier protein transacylase.
Malonyl transacylase.
Malonyl transferase.
Malonyl-CoA-acyl carrier protein transacylase.
Malonyl-CoA/dephospho-CoA acyltransferase.
MCAT.
Reaction catalysed
Malonyl-CoA + [acyl-carrier-protein] <=> CoA + malonyl-[acyl-carrier-protein]
Comment(s)
  • Essential, along with EC 2.3.1.38, for the initiation of fatty-acid biosynthesis in bacteria.
  • Also provides the malonyl groups for polyketide biosynthesis.
  • The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis.
  • In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7) is the preferred substrate.
  • This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 and EC 4.1.1.89.
  • Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase.
  • In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot whereas the enzyme from Pseudomonas putida can use both as substrates.
  • The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group.
Cross-references
BRENDA2.3.1.39
EC2PDB2.3.1.39
ExplorEnz2.3.1.39
PRIAM enzyme-specific profiles2.3.1.39
KEGG Ligand Database for Enzyme Nomenclature2.3.1.39
IUBMB Enzyme Nomenclature2.3.1.39
IntEnz2.3.1.39
MEDLINEFind literature relating to 2.3.1.39
MetaCyc2.3.1.39
UniProtKB/Swiss-Prot
A7Z4X8, BAEC_BACA2;  A7Z4Y0, BAEE_BACA2;  P71019, FABD_BACSU;  
Q8K9J6, FABD_BUCAP;  Q89AH0, FABD_BUCBP;  Q8T3L6, FABD_DROME;  
Q8X8I7, FABD_ECO57;  P0AAJ0, FABD_ECOL6;  P0AAI9, FABD_ECOLI;  
P43712, FABD_HAEIN;  Q8IVS2, FABD_HUMAN;  Q8R3F5, FABD_MOUSE;  
P63459, FABD_MYCBO;  A0R0B2, FABD_MYCS2;  P9WNG4, FABD_MYCTO;  
P9WNG5, FABD_MYCTU;  O85140, FABD_SALTY;  O13698, FABD_SCHPO;  
Q5HGK3, FABD_STAAC;  Q99UN8, FABD_STAAM;  Q7A5Z3, FABD_STAAN;  
Q6GHK5, FABD_STAAR;  Q6G9Y3, FABD_STAAS;  Q93QD4, FABD_STAAU;  
Q7A124, FABD_STAAW;  P73242, FABD_SYNY3;  Q12283, FABD_YEAST;  
P34731, FAS1_CANAX;  Q9UUG0, FAS1_SCHPO;  P34229, FAS1_YARLI;  
P07149, FAS1_YEAST;  Q71SP7, FAS_BOVIN;  P12276, FAS_CHICK;  
P49327, FAS_HUMAN;  P19096, FAS_MOUSE;  P12785, FAS_RAT;  
Q9R9J2, FENF_BACIU;  O34825, PKSC_BACSU;  O34787, PKSE_BACSU;  
Q92215, TOXC_COCCA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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