ENZYME entry: EC 2.3.3.10

Accepted Name
Hydroxymethylglutaryl-CoA synthase.
Alternative Name(s)
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating).
3-hydroxy-3-methylglutaryl CoA synthetase.
3-hydroxy-3-methylglutaryl coenzyme A synthase.
3-hydroxy-3-methylglutaryl coenzyme A synthetase.
3-hydroxy-3-methylglutaryl-CoA synthase.
3-hydroxy-3-methylglutaryl-coenzyme A synthase.
Acetoacetyl coenzyme A transacetase.
Beta-hydroxy-beta-methylglutaryl-CoA synthase.
HMG-CoA synthase.
Hydroxymethylglutaryl coenzyme A synthase.
Hydroxymethylglutaryl coenzyme alpha-condensing enzyme.
Reaction catalysed
Acetyl-CoA + H(2)O + acetoacetyl-CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
Comment(s)
Formerly EC 4.1.3.5.
Cross-references
PROSITEPDOC00942
BRENDA2.3.3.10
EC2PDB2.3.3.10
ExplorEnz2.3.3.10
PRIAM enzyme-specific profiles2.3.3.10
KEGG Ligand Database for Enzyme Nomenclature2.3.3.10
IUBMB Enzyme Nomenclature2.3.3.10
IntEnz2.3.3.10
MEDLINEFind literature relating to 2.3.3.10
MetaCyc2.3.3.10
UniProtKB/Swiss-Prot
P54961, HMCS1_BLAGE;  P23228, HMCS1_CHICK;  P13704, HMCS1_CRIGR;  
Q01581, HMCS1_HUMAN;  Q8JZK9, HMCS1_MOUSE;  Q5R7Z9, HMCS1_PONAB;  
P17425, HMCS1_RAT;  P54870, HMCS2_BLAGE;  Q2KIE6, HMCS2_BOVIN;  
P54868, HMCS2_HUMAN;  P54869, HMCS2_MOUSE;  O02734, HMCS2_PIG;  
P22791, HMCS2_RAT;  P54872, HMCSA_DICDI;  Q86HL5, HMCSB_DICDI;  
P54873, HMCS_ARATH;  P54871, HMCS_CAEEL;  P54874, HMCS_SCHPO;  
P54839, HMCS_YEAST;  Q9FD71, HMGCS_ENTFL;  D4GWR6, HMGCS_HALVD;  

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