ENZYME entry: EC 2.4.1.175

Accepted Name
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
Alternative Name(s)
Chondroitin synthase.
Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N- acetylgalactosaminyltransferase.
N-acetylgalactosaminyltransferase II.
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D- galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase.
Uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II.
Reaction catalysed
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Comment(s)
  • Involved in the biosynthesis of chondroitin sulfate.
  • The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
Cross-references
BRENDA2.4.1.175
EC2PDB2.4.1.175
ExplorEnz2.4.1.175
PRIAM enzyme-specific profiles2.4.1.175
KEGG Ligand Database for Enzyme Nomenclature2.4.1.175
IUBMB Enzyme Nomenclature2.4.1.175
IntEnz2.4.1.175
MEDLINEFind literature relating to 2.4.1.175
MetaCyc2.4.1.175
UniProtKB/Swiss-Prot
Q86X52, CHSS1_HUMAN;  Q6ZQ11, CHSS1_MOUSE;  P45895, CHSS2_CAEEL;  
Q8IZ52, CHSS2_HUMAN;  Q6IQX7, CHSS2_MOUSE;  Q70JA7, CHSS3_HUMAN;  
Q5DTK1, CHSS3_MOUSE;  Q8L0V4, CHS_ECOLX;  Q9CMP0, CHS_PASMU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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