To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.4.1.214

Accepted Name
Glycoprotein 3-alpha-L-fucosyltransferase.
Alternative Name(s)
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn- peptide) alpha-1->3-fucosyltransferase.
GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase.
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase.
Reaction catalysed
GDP-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine <=> GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-beta-D-glucosaminyl)asparagine
Cofactor(s)
Mn(2+).
Comment(s)
  • The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue.
  • This enzyme catalyzes a reaction similar to that of EC 2.4.1.68, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,3-linkage rather than an alpha-1,6-linkage.
  • The N-glycan products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
Cross-references
BRENDA2.4.1.214
EC2PDB2.4.1.214
ExplorEnz2.4.1.214
PRIAM enzyme-specific profiles2.4.1.214
KEGG Ligand Database for Enzyme Nomenclature2.4.1.214
IUBMB Enzyme Nomenclature2.4.1.214
IntEnz2.4.1.214
MEDLINEFind literature relating to 2.4.1.214
MetaCyc2.4.1.214
UniProtKB/Swiss-Prot
Q9VUL9, FUCTA_DROME;  Q9LJK1, FUT11_ARATH;  G5EDR5, FUTA_CAEEL;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-