ENZYME

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ENZYME entry: EC 2.4.1.214

Accepted Name

Glycoprotein 3-alpha-L-fucosyltransferase.

Alternative Name(s)

GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn- peptide) alpha-1->3-fucosyltransferase.

GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase.

GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase.

Reaction catalysed

GDP-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine <=> GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-beta-D-glucosaminyl)asparagine

Cofactor(s)

Manganese.

Comment(s)

The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue.
This enzyme catalyzes a reaction similar to that of EC 2.4.1.68, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,3-linkage rather than an alpha-1,6-linkage.
The N-glycan products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).

Cross-references

BRENDA

2.4.1.214

EC2PDB

2.4.1.214

ExplorEnz

2.4.1.214

PRIAM enzyme-specific profiles

2.4.1.214

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.214

IUBMB Enzyme Nomenclature